Effects of Binders and Moisture Content on the Disintegration, Hardness and Friability of Paracetamol and Orphenadrine Citrate Tablets

Muti, H.; Othman, Sadeq

doi:10.3109/03639048909052516

Cited by 12 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the application calculations reveal that Na-CMC and PVP K-30 exert a significant negative influence on disintegration time, signifying that higher concentrations of Na-CMC and PVP K-30 lead to prolonged disintegration times. According to Muti and Othman, the use of Na-CMC produces preparations with the longest disintegration time and highest friability [11]. Conversely, primogel and CCS demonstrate a substantial positive impact on the reduction of disintegration time.…”

Section: Disintegration Timementioning

confidence: 99%

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Soraya,

Putri,

Purwoto

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Recently, seaweed-based capsule shells have become more popular because of their reliable quality and animal-free source. But these shells’ prolonged disintegration times are a common problem. This research aims to look for formulations with disintegrant substitution or a combination of several disintegrants to obtain capsule shells that disintegrate quickly. Several studies have explored the incorporation of additional disintegrants such as Polyvinylpyrrolidone (PVP) K-30, Sodium starch glycolate (primogel), Croscarmellose sodium (SSC), and Sodium carboxymethylcellulose (Na-CMC) to address this challenge. The study investigates various combinations of disintegrants in the formulation of capsule shells to achieve rapid disintegration time. The variation in composition of disintegrants was determined using Simplex Lattice Design (SLD) in Design Expert® 13.0.12. Balancing the desirable characteristics of quick disintegration with other factors posed a significant challenge. All types of disintegrants exerted a notable influence on the response variables. To achieve a substantial reduction in disintegration time, the utilization of primogel is strongly recommended. However, it should be noted that primogel contains minerals that do not disintegrate, resulting in an elevated ash content. In contrast, PVP K-30 demonstrates promising performance but falls slightly short of primogel’s efficacy in accelerating disintegration. Additionally, PVP K-30 exhibits a marked advantage in minimizing ash content within the capsule shell. Optimization results indicate that a combination of PVP K-30 and primogel yields a capsule shell with the fastest disintegration time, approximately 23.908 minutes, while maintaining a minimal ash content of 10.487%.

show abstract

Section: Disintegration Timementioning

confidence: 99%

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Soraya,

Putri,

Purwoto

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…A low moisture content (in the range 1% to 4% w/w) in tablets increases the tensile strength [40,44,45,46]. Exceeding the limit value of the water content in the tablet results in a significant reduction in tensile strength and disintegration [47]. An understanding of sorption properties is needed to enable control over the quantity of water that is adsorbed by a given nanomaterial.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Size Effect on Water Vapour Adsorption by Hydroxyapatite

et al. 2019

View full text Add to dashboard Cite

Handling and properties of nanoparticles strongly depend on processes that take place on their surface. Specific surface area and adsorption capacity strongly increase as the nanoparticle size decreases. A crucial factor is adsorption of water from ambient atmosphere. Considering the ever-growing number of hydroxyapatite nanoparticles applications, we decided to investigate how the size of nanoparticles and the changes in relative air humidity affect adsorption of water on their surface. Hydroxyapatite nanoparticles of two sizes: 10 and 40 nm, were tested. It was found that the nanoparticle size has a strong effect on the kinetics and efficiency of water adsorption. For the same value of water activity, the quantity of water adsorbed on the surface of 10 nm nano-hydroxyapatite was five times greater than that adsorbed on the 40 nm. Based on the adsorption isotherm fitting method, it was found that a multilayer physical adsorption mechanism was active. The number of adsorbed water layers at constant humidity strongly depends on particles size and reaches even 23 layers for the 10 nm particles. The amount of water adsorbed on these particles was surprisingly high, comparable to the amount of water absorbed by the commonly used moisture-sorbent silica gel.

show abstract

“…39 Generally, the stability of the three brands at all the environmental conditions was not remarkably affected at 24 months of storage except brand P3 that were kept out-door and in the trunk. Tsvetkova et al, 40 Muti and Othman, 41 Raman et al 42 observed that paracetamol tablets stability characteristics were not significantly affected under different storage conditions.…”

mentioning

confidence: 99%

Pharmaceutical Stability of Brands of Paracetamol Tablets under Different Environmental Conditions

Adeleye¹,

Ayorinde²,

Bakre³

et al. 2019

TJNPR

View full text Add to dashboard Cite

Drug stability is defined as the capacity of a drug substance or drug product to maintain its identity, strength, quality, and purity within official specification throughout its shelf life. 1 The stability of a drug product must have to be maintained throughout its shelf-life otherwise the quality, safety, potency and efficacy will be compromised. 2,3 All form of drug delivery system is subject to changes under the influence of some environmental factors such as light, humidity and temperature. 4-7 These changes could lead to deterioration and degradation usually as a result of oxidation, hydrolysis, photolysis, thermolysis, etc, thus making consumers at risk of some drug related problems ranging from suboptimal treatment, therapeutic failure, adverse reactions, toxicity, etc. 3,8-10 The pharmaceutical changes that can occur to solid dosage forms (tablets) are; changes in tablet dimensions, weight, colour, hardness, friability, drug content, disintegration and dissolution. Environmental factors are unavoidable conditions which drugs will have to pass through during transportation, storage and use. 11-13 This is very essential in determining the integrity of these products. So, for stability to be maintained, these factors are of utmost importance and must be put under control. It has been reported by many authors that, stability

show abstract

Effects of Binders and Moisture Content on the Disintegration, Hardness and Friability of Paracetamol and Orphenadrine Citrate Tablets

Cited by 12 publications

References 18 publications

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Nanoparticle Size Effect on Water Vapour Adsorption by Hydroxyapatite

Pharmaceutical Stability of Brands of Paracetamol Tablets under Different Environmental Conditions

Contact Info

Product

Resources

About