Effects of Biliary Obstruction on Hepatic Clearance of Bacteria

Allen, Melody O'Connor; Wilton, Peter B.; Barke, R. A.; Gerding, Dale N.; Förström, L; Shafer, Rex B.; Vennes, Jack A.

doi:10.1001/archsurg.1989.01410080109018

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Arch Surg

1989

DOI: 10.1001/archsurg.1989.01410080109018

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Effects of Biliary Obstruction on Hepatic Clearance of Bacteria

Melody O'Connor Allen

Peter B. Wilton²,

R. A. Barke³

et al.

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Cited by 4 publications

References 17 publications

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Effects of Extrahepatic Obstructive Jaundice on Kupffer Cell Clearance Capacity

Clements

Halliday²,

McCaigue³

et al. 1993

Arch Surg

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Systemic endotoxemia consistently occurs in jaundiced patients undergoing surgery. Kupffer cell dysfunction is implicated in the development of endotoxemia and its postoperative complications. A novel in situ single-pass hepatic perfusion technique using a fluorescein isothiocyanate-labeled latex probe was developed for measuring Kupffer cell clearance capacity and was applied in an animal model of biliary obstruction. Control rats and rats jaundiced for 1, 2, 3, and 4 weeks' duration were studied. Kupffer cell clearance capacity, plasma bilirubin, endotoxin, and anticore glycolipid concentrations were measured. Maximal hyperbilirubinemia preceded reduced Kupffer cell clearance capacity. Rats jaundiced for greater than 2 weeks had a significantly decreased Kupffer cell clearance capacity but significantly higher endotoxin and anticore glycolipid concentrations. Anticore glycolipid concentrations correlated strongly with systemic endotoxemia and both were inversely correlated with duration of jaundice. Impairment of Kupffer cell clearance capacity may contribute to endotoxemia associated with cholestasis.

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Effects of Extrahepatic Obstructive Jaundice on Kupffer Cell Clearance Capacity

Clements

Halliday²,

McCaigue³

et al. 1993

Arch Surg

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Effect of 5-Lipoxygenase Inhibition on Kupffer Cell Clearance Capacity in Obstructive Jaundiced Rats

Dağlar

Kama

Atlı

et al. 2001

Journal of Surgical Research

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Effects of cimetidine on IL-2 and T suppressor cell function in rats with obstructive jaundice

Ding

Xiong

et al. 1994

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Effects of Biliary Obstruction on Hepatic Clearance of Bacteria

Cited by 4 publications

References 17 publications

Effects of Extrahepatic Obstructive Jaundice on Kupffer Cell Clearance Capacity

Effects of Extrahepatic Obstructive Jaundice on Kupffer Cell Clearance Capacity

Effect of 5-Lipoxygenase Inhibition on Kupffer Cell Clearance Capacity in Obstructive Jaundiced Rats

Effects of cimetidine on IL-2 and T suppressor cell function in rats with obstructive jaundice

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