Effect of 5-Lipoxygenase Inhibition on Kupffer Cell Clearance Capacity in Obstructive Jaundiced Rats

“…Perioperative complications in patients with obstructive jaundice included infections, endotoxemia, renal failure, stress ulceration, disseminated intravascular coagulation, and wound dehiscence [14,15] . Numerous reports suggested that in obstructive jaundice there was not only impairment of hepatocellular function but also depression of Kupffer cell activity and ultimately hepatic structural damage, leading to the development of portal hypertension [16,17] . In addition, it could result in depressed wound healing, significant portal and systemic endotoxaemia, decreased reticuloendothelial cell function, reduced T cell responses, depressed non-specific cellmediated immunity, decreased bacterial clearance and increased bacterial translocation [18,19] .…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats

Wang

Dou²,

Li³

et al. 2003

WJG

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AIM:To investigate the hepatocellular apoptosis after hepatectomy in obstructive jaundice and biliary decompression rats. METHODS:After bile duct ligation for 7 days, rats were randomly divided into OB group in which the rats underwent 70 % hepatectomy, OB-CD group in which the rats underwent hepatectomy accompanied by choledochoduodenostomy, CDHx group in which the rats underwent choledochoduodenostomy and then received 70 % hepatectomy on the fifth day after biliary decompression. The control group (Hx group) only underwent hepatectomy. RESULTS:The level of total serum bilirubin and serum enzymes was significantly lower in CD-Hx group than in OB-CD and OB groups on day 1, 3 and 5 after hepatectomy. The apoptotic index was significantly lower in CD-Hx group than in OB-CD and OB groups on day 3 and 5. The oligonucleosomal DNA fragments and Caspase-3 activity were also lower in CD-Hx group than in OB-CD and OB groups 3 days after hepatectomy, without differences between CD-Hx and Hx groups.CONCLUSION: Hepatocellular apoptosis plays vital roles in jaundice rats, and biliary decompression is more effective in treatment of patients with severe jaundice before operation.Wang DS, Dou KF, Li KZ, Gao ZQ, Song ZS, Liu ZC. Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats.

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“…Each dose was homogenized in 1 cc ethanol and injected via ip. A previous study has found ethanol not to be harmful to the liver [13].…”

Section: Chemicalsmentioning

confidence: 99%