Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review

Zhang, Chaohe; Sheng, Jiyao; Li, Guangquan; Zhao, Lihong; Wang, Yicun; Yang, Wei; Yao, Xiaoxiao; Sun, Luyi; Zhang, Zhuo; Cui, Ranji

doi:10.3389/fphar.2019.01461

Cited by 72 publications

(53 citation statements)

References 90 publications

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Section: Discussionmentioning

confidence: 99%

“…Berberine is an alkaloid extracted from coptis, phellodendron and three needles. It has significant antibacterial, antiarrhythmic, antihypertensive and blood lipid regulating effects 11 . A large number of studies have shown that berberine has a significant antitumor effect and can participate in the antitumor process of many kinds of cancer, such as liver cancer 12 , lung cancer 13 , colon cancer 14 , esophageal cancer 15 , leukemia 16 , and so on.…”

Section: Introductionmentioning

confidence: 99%

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Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells

Zou

Pei

et al. 2021

J. Cancer

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Background: Berberine, as an alkaloid, has a significant antitumor effect, but its mechanism in tumor metabolism, especially the Warburg effect has not been elucidated. Objectives: To study the molecular mechanism of berberine regulating the Warburg effect in ovarian cancer cells. Methods: Treatment by berberine in SKOV3 and 3AO cells or inhibited by miR-145 inhibitor transfection in berberine-treated cells to examine the changes in HK2 expression, glucose consumption and lactate production. The methylation status in the promoter region of pre-miR-145 gene was examined by bisulfite sequencing. Dual-luciferase reporter assay was conducted to verify the direct binding of miR-145 to HK2. Finally, the expression of TET3 in ovarian cancer was investigated by quantitative real-time PCR and immunohistochemistry. Results: We found berberine inhibited the Warburg effect by up-regulating miR-145, miR-145 targeted HK2 directly. Berberine increased the expression of miR-145 by promoting the expression of TET3 and reducing the methylation level of the promoter region of miR-145 precursor gene. We further found that TET3 expression was negatively correlated with clinical stage and pathological grade. Conclusions: Our results revealed berberine increased the TET3-mediated demethylation and promoted the suppression of miR-145 on HK2 to antagonize the Warburg effect of ovarian cancer cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells

Zou

Pei

et al. 2021

J. Cancer

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“…Protopine and protoberberine derivatives such as coptisine and berberine have several pharmacological activities. Beside antimicrobial activity, analgesic, anti-inflammatory, anticancer, antithrombotic, hypoglycaemic, hypolipidaemic, hepatoprotective, and neuroprotective properties were also reported [ 36 , 37 , 38 , 39 ]. Apart from protoberberine alkaloids, several benzophenanthridine derivatives, such as chelidonine, chelerythrine and sanguinarine were also present in extracts of C. solida and P. lutea .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea

et al. 2020

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Corydalis and Pseudofumaria are two closely related genera from the Papaveraceae subfamily Fumarioideae with Corydalis solida (C. solida) and Pseudofumaria lutea (P. lutea) as two representative species. Phytochemical analysis revealed significant differences in the quality and quantity of isoquinoline alkaloids, phenolic compounds and non-phenolic carboxylic acids between aerial and underground parts of both species. Using the Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) technique, 21 compounds were identified: five protoberberine derivatives, three protopine derivatives, four phenanthridine derivatives, as well as three carboxylic acids, two hydroxycinnamic acids, one chlorogenic acid, one phenolic aldehyde, and two flavonoids. Moroever, significant differences in the content of individual compounds were observed between the two studied species. The phytochemical profile of C. solida showed a higher variety of compounds that were present in lower amounts, whereas P. lutea extracts contained fewer compounds but in larger quantities. Protopine was one of the most abundant constituents in C. solida (440–1125 µg/g d.w.) and in P. lutea (1036–1934 µg/g d.w.). Moreover, considerable amounts of coptisine (1526 µg/g) and quercetin (3247 µg/g) were detected in the aerial parts of P. lutea. Extracts from aerial and underground parts of both species were also examined for the antimicrobial potential against S. aureus, P. aeruginosa and C. albicans. P. lutea herb extract was the most effective (MIC at 0.39 mg/L) against all three pathogens.

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“…Berberine is a benzylisoquinoline alkaloid commonly found in the plants of the genus Berberis [167,168]. In a recent study by Zhang et al, it was shown to induce programmed necrosis in LNCaP and PC-82 PCa cell lines.…”

Section: Natural Compounds Inducing Canonical and Non-canonical Cellmentioning

confidence: 99%

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

Fontana

Raimondi

Marzagalli

et al. 2020

Cells

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Prostate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa; in this condition, tumor cells acquire the ability to escape cell death and develop resistance to current therapies. Thus, new therapeutic approaches for PCa management are urgently needed. In this setting, natural products have been extensively studied for their anti-PCa activities, such as tumor growth suppression, cell death induction, and inhibition of metastasis and angiogenesis. Additionally, numerous studies have shown that phytochemicals can specifically target the androgen receptor (AR) signaling, as well as the PCa stem cells (PCSCs). Interestingly, many clinical trials have been conducted to test the efficacy of nutraceuticals in human subjects, and they have partially confirmed the promising results obtained in vitro and in preclinical models. This article summarizes the anti-cancer mechanisms and therapeutic potentials of different natural compounds in the context of PCa prevention and treatment.

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Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review

Cited by 72 publications

References 90 publications

Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells

Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells

Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

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