Effects of benactyzine on an equilibrium and multiple response task in rhesus monkeys

Farrer, Donald N.; Yochmowitz, M.G.; Mattsson, Joel L.; Lof, Neal E; Bennett, Calvin

doi:10.1016/0091-3057(82)90423-3

Cited by 14 publications

(2 citation statements)

References 8 publications

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“…The Primate Equilibrium Platform (PEP) is a continuous compensatory tracking task that has been described elsewhere in detail (4,10). Briefly, the primate was seated in a restraint chair mounted inside the working volume of the ITS (see Fig.…”

Section: Behavioral Taskmentioning

confidence: 99%

The Effects of Infrasound on Rhesus Monkey Performance of a Continuous Compensatory Tracking Task

Sherry

Cook

Jauchem³

et al. 2008

Journal of Low Frequency Noise, Vibration and Active Control

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Background: Potential bio-behavioral effects of infrasonic energy (<20 Hz) have generally been considered to be due to extra-aural (non-hearing) mechanisms. Since systems that deliver acoustic energy, including infrasound, are being considered for use as non-lethal weapons, it is important to elucidate the possible aural and extra-aural effects of such energy. Methods: Subjects (5 adult male rhesus monkeys) engaged in a continuous compensatory tracking task. The effect of short-term exposure to high-intensity infrasound (160 dB), using a custom-made system, on tracking task performance was measured. The effects of the infrasound exposure on auditory measures (otoacoustic emissions and auditory brainstem evoked potentials) were also examined. Results: Tracking behavior of the subjects was substantially disrupted by exposure to 10-Hz infrasound at 160 dB. There was no evidence of any post-exposure alterations in tympanometry, distortion product otoacoustic emissions, or in auditory brainstem evoked potentials. Conclusions: Although the present experiments showed significant effects on performance, further experiments using larger working volumes would have to be undertaken to address the potential uses of such a device.

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Section: Behavioral Taskmentioning

confidence: 99%

The Effects of Infrasound on Rhesus Monkey Performance of a Continuous Compensatory Tracking Task

Sherry

Cook

Jauchem³

et al. 2008

Journal of Low Frequency Noise, Vibration and Active Control

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show abstract

“…The PEP is a continuous, compensatory-tracking task that has been extensively used in assessments of the effects of nerve agents and associated drugs, such as prophylactics, antidotes, and their combinations (Farrer et al, 1982;Blick et al, 1994). Performance on the PEP task measures fine motor control involved in joystick manipulation and the integrity of the complex sensorimotor system necessary for maintaining equilibrium and orientation in space.…”

Section: Apparatusmentioning

confidence: 99%

Lack of Effects on Goal-Directed Behavior of High-Intensity Infrasound in a Resonant Reverberant Chamber

Cook¹,

Sherry²,

Brown³

et al. 2001

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Acetylcholinesterase: A Pretreatment Drug for Organophosphate Toxicity

Doctor

Blick

Gentry

et al. 1992

Multidisciplinary Approaches to Cholinesterase Functions

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Effects of benactyzine on an equilibrium and multiple response task in rhesus monkeys

Cited by 14 publications

References 8 publications

The Effects of Infrasound on Rhesus Monkey Performance of a Continuous Compensatory Tracking Task

The Effects of Infrasound on Rhesus Monkey Performance of a Continuous Compensatory Tracking Task

Lack of Effects on Goal-Directed Behavior of High-Intensity Infrasound in a Resonant Reverberant Chamber

Acetylcholinesterase: A Pretreatment Drug for Organophosphate Toxicity

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