Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial

Sjöström, Lars; Gummesson, Anders; Sjöström, C. David; Narbro, Kristina; Peltonen, Markku; Wedel, Hans; Bengtsson, Calle; Bouchard, Claude; Carlsson, Björn; Dahlgren, S; Jacobson, Peter; Karason, Kristjan; Karlsson, Jan; Larsson, Bo; Lindroos, Anna‐Karin; Lönroth, Hans; Näslund, Ingmar; Olbers, Torsten; Stenlöf, Kaj; Torgerson, Jarl; Carlsson, Lena

doi:10.1016/s1470-2045(09)70159-7

Cited by 650 publications

(443 citation statements)

References 32 publications

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“…[9][10][11]27 The few studies that have previously assessed the overall risk of cancer after obesity surgery have not had sufficient statistical power or length of follow-up to reliably evaluate any specific changes in the risk of colorectal cancer. [8][9][10][11] The studies that reported the number of colorectal cancer cases after obesity surgery found only 35, 25, and 2 cases. 8,10,11 In a cohort study from the United States, a 30% statistically nonsignificant decreased risk of colorectal cancer was reported in patients after gastric bypass surgery compared with morbidly obese controls.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Previous studies addressing cancer risk have been relatively small or have described only a limited follow-up period after surgery. [8][9][10][11] In our recent cohort study, an unexpected finding was that the risk of colorectal cancer seemed to increase with time after obesity surgery, whereas no such increase was found for the other main obesity-related cancers, including cancer of the breast, prostate, endometrium, and kidney. 8 However, obesity is a recognized risk factor for colorectal cancer, 12 and it was not possible to distinguish between colorectal cancer risk associated with excess body weight and that associated with previous obesity surgery.…”

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Increased Risk of Colorectal Cancer After Obesity Surgery

Derogar¹,

et al. 2013

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Increased Risk of Colorectal Cancer After Obesity Surgery

Derogar¹,

et al. 2013

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“…In non-pregnant subjects with grade II obesity and above, gastric bypass surgery is associated with sustained weight loss of 26% body weight and an improvement in metabolic parameters of hyperglycaemia, hypertriglyceridaemia and hypertension. [103][104][105] Patients with more moderate degrees of obesity, BMI range between 30 and 40 kg/m 2 also show significant weight loss and metabolic benefit from LAP banding. 106 Few studies have investigated the effects of weight loss following bariatric surgery on adverse pregnancy outcome.…”

Section: Lipid Turnovermentioning

confidence: 99%

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

Dennedy

Dunne

2010

Best Practice & Research Clinical Endocrinology & Metab

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“…Current guidelines for bariatric surgery are based on BMI alone or on BMI in combination with comorbidities [11,12]. In the Swedish Obese Subjects (SOS) study (ClinicalTrials.gov registration NCT01479452), however, we have repeatedly found that baseline BMI is not a predictor of long-term bariatric surgery outcomes such as reduction of cardiovascular events, overall mortality and cancer or type 2 diabetes prevention and remission [3,9,[13][14][15]. In this study, we analyse the SOS study data in more detail to reveal whether incidence and remission rates for type 2 diabetes differ among participants with different baseline BMI but similar weight loss over 2 years.…”

Section: Introductionmentioning

confidence: 99%

Incidence and remission of type 2 diabetes in relation to degree of obesity at baseline and 2 year weight change: the Swedish Obese Subjects (SOS) study

et al. 2015

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Aims/hypothesis The aim of this work was to analyse the rates of incidence and remission of type 2 diabetes in relation to baseline BMI and weight change in the prospective, controlled Swedish Obese Subjects (SOS) study. Methods Three-thousand four-hundred and eighty-five obese individuals receiving bariatric surgery or conventional treatment were grouped into four baseline BMI categories (<35, 35-40, 40-45 or ≥45 kg/m 2 ) and five weight-change categories according to their BMI at 2 years (increase [≥1 BMI unit increase], no change [less than 1 BMI unit change], minor reduction [−1 to −9 BMI units], medium reduction [−10 to −14 BMI units] and major reduction [< −15 BMI units]). The incidence and remission of diabetes at 2 years was assessed. Results Among individuals with no weight change, diabetes incidence rates were 5.5%, 7.4%, 8.3% and 5.2%, in the four baseline BMI categories, respectively. In those with an initial BMI of 35-40, 40-45 and ≥45 kg/m 2 who attained a minor reduction in weight, the corresponding rates were 1.3%, 1.2% and 3.4%, respectively. In both the medium-and majorweight-reduction groups, diabetes incidence was ≤0.5%. Among individuals with diabetes at baseline, the remission rates were 15.3-26.9% in the no-weight-change groups, and 48.1-70% for individuals who attained a minor weight reduction. In the medium-and major-weight-reduction groups, the remission rate was 77-97%. There were no differences in 2 year incidence and remission rates between different baseline BMI groups that achieved the same degree of weight reduction. Conclusions/interpretation In obese individuals, the favourable effect of weight reduction on type 2 diabetes incidence and remission is independent of initial BMI. Trial registration ClinicalTrials.gov number NCT01479452

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Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial

Cited by 650 publications

References 32 publications

Increased Risk of Colorectal Cancer After Obesity Surgery

Increased Risk of Colorectal Cancer After Obesity Surgery

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

Incidence and remission of type 2 diabetes in relation to degree of obesity at baseline and 2 year weight change: the Swedish Obese Subjects (SOS) study

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