Effects of azadirachtin on the regulation of midgut peristalsis by the stomatogastric nervous system inLocusta migratoria

Trumm, Peter; Dorn, August

doi:10.1007/bf02994020

Cited by 30 publications

(18 citation statements)

References 52 publications

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“…This is in agreement with other studies on Locusta migratoria [79][80][81] , which were pointed out that azadirachtin has an inhibitory effect upon gut peristalsis. known effect of azadirachtin, which are predominantly deterrent and growth regulator [13,[82][83] .…”

Section: Decrease Of Adipokinetic Responsesupporting

confidence: 94%

“…This is in general agreement with previous observations [13,85] . Trumm and Dorn, [81] reported that the reduction of food intake after the azadirachtin treatment was accompanied and probably caused by a prolonged retention of food in the crop and a strongly retarded passage through the midgut. The effect of azadirachtin on gut physiology have been mostly related to efficiency of diet conversion and inhibition of digestive enzymes [86][87] .…”

Section: Decrease Of Adipokinetic Responsementioning

confidence: 99%

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Effect of Different Neem Products on the Mortality and Fitness of Adult Schistocerca gregaria (Forskal)

Al-Fifi

2009

sci

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Abstract. Various neem products were tested against resting and flying Schistocerca gregaria. Two of the products namely neem Azal-F and the unclarified neem oil were obtained from the Company Trifolio, whereas neem oil enriched and pure neem oil, were a gift of Prof. Schmutterer (University of Giessen). The treatment during flight activity caused, for all products applied an increase of the mortality rate, except the neem oil enriched and pure neem oil of Giessen, up to 70 and 90% respectively. The same products, however, sprayed on resting locusts did not show any remarkable mortality. But this treatment reduced the fitness of the locusts in terms of their flight performance, as well as their adipokinetic potency. In consequence of this, it is to expect that neem treated locusts will not be able to cover long distances. That means the lipid mobilizing system necessary to provide the flight muscles with "fuel" (lipids) is disturbed severely.

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Section: Decrease Of Adipokinetic Responsesupporting

confidence: 94%

Section: Decrease Of Adipokinetic Responsementioning

confidence: 99%

Effect of Different Neem Products on the Mortality and Fitness of Adult Schistocerca gregaria (Forskal)

Al-Fifi

2009

sci

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“…This change in the workers' survival profile can be explained by an exchange between the well-known gustatory and physiological antifeedant effects of azadirachtin on insects [21][22][23][24][25][26] . The gustatory antifeedancy immediately stops the utilization of the energy source (sugar water) because it blocks the food intake, while the physiological antifeedancy has a palliative impact reducing the food intake and/or uptake [21][22][23][24][25][26] . Therefore, the fast decline of the survival in worker bumblebees exposed to high concentrations of azadirachtin may be due to the gustatory antifeedancy that blocked the food intake.…”

Section: Discussionmentioning

confidence: 99%

Lethal and sublethal effects of azadirachtin on the bumblebee Bombus terrestris (Hymenoptera: Apidae)

et al. 2014

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Background: Lethal and sublethal effects of azadirachtin were studied on Bombus terrestris via oral exposure in the laboratory to bring out the potential risks of the compound to this important pollinator.Results: Microcolonies chronically exposed to azadirachtin via treated sugar water during 11 weeks in the laboratory exhibited a high mortality ranging from 32 to 100 % with a range of concentrations between 3.2 and 320 mg litre , azadirachtin significantly inhibited the egg laying and, consequently, the production of drones during 6 weeks. When azadirachtin was tested under an experimental setup in the laboratory where bumblebees need to forage for food, the sublethal effects were stronger as the numbers of drones were reduced already with a concentration of 0.64 mg litre -1 . Besides, a negative correlation was found between the body mass of male offspring and azadirachtin concentration.Conclusion: Azadirachtin can affect B. terrestris with a range of sublethal effects. This study confirms the need to test compounds on their safety, especially when they have to perform complex tasks such as foraging.

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“…Serotonergic neurons are also found in significant numbers in the vertebrate ENS. Serotonin is necessary for peristaltic intestinal motility in both vertebrates (Gershon, 2004) and invertebrates (Luffy and Dorn, 1992), and depletion of serotonin in locusts results in disturbance of food propagation through the gut (Trumm and Dorn, 2000). A dual role of serotonin on midgut motility has been demonstrated in the stick insect: an activating modulatory role on rhythm generation in the enteric ganglia, and a direct stimulation of contraction of the gut itself (Luffy and Dorn, 1992).…”

mentioning

confidence: 99%

“…A broad variety of neurotransmitters has been found in the insect ENS, e.g., various peptides (Copenhaver and Taghert, 1989a;Duve and Thorpe, 2003;Hill and Orchard, 2003;Clark et al, 2006), GABA (Luffy and Dorn, 1992;Trumm and Dorn, 2000), acetylcholine (Bicker et al, 2004), and serotonin (Davis, 1985;Klemm et al, 1986;Radwan et al, 1989;Luffy and Dorn, 1992;Molaei and Lange, 2003). Serotonergic neurons form a large group among ENS neurons.…”

mentioning

confidence: 99%

Embryonic differentiation of serotonin‐containing neurons in the enteric nervous system of the locust (Locusta migratoria)

Stern¹,

Knipp²,

Bicker³

2007

J of Comparative Neurology

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The enteric nervous system (ENS) of the locust consists of four ganglia (frontal and hypocerebral ganglion, and the paired ingluvial ganglia) located on the foregut, and nerve plexus innervating fore- and midgut. One of the major neurotransmitters of the ENS, serotonin, is known to play a vital role in gut motility and feeding. We followed the anatomy of the serotonergic system throughout embryonic development. Serotonergic neurons are generated in the anterior neurogenic zones of the foregut and migrate rostrally along the developing recurrent nerve to contribute to the frontal ganglion. They grow descending neurites, which arborize in all enteric ganglia and both nerve plexus. On the midgut, the neurites closely follow the leading migrating midgut neurons. The onset of serotonin synthesis occurs around halfway through development-the time of the beginning of midgut closure. Cells developing to serotonergic phenotype express the serotonin uptake transporter (SERT) significantly earlier, beginning at 40% of development. The neurons begin SERT expression during migration along the recurrent nerve, indicating that they are committed to a serotonergic phenotype before reaching their final destination. After completion of the layout of the enteric ganglia (at 60%) a maturational phase follows, during which serotonin-immunoreactive cell bodies increase in size and the fine arborizations in the nerve plexus develop varicosities, putative sites of serotonin release (at 80%). This study provides the initial step for future investigation of potential morphoregulatory functions of serotonin during ENS development.

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Effects of azadirachtin on the regulation of midgut peristalsis by the stomatogastric nervous system inLocusta migratoria

Cited by 30 publications

References 52 publications

Effect of Different Neem Products on the Mortality and Fitness of Adult Schistocerca gregaria (Forskal)

Effect of Different Neem Products on the Mortality and Fitness of Adult Schistocerca gregaria (Forskal)

Lethal and sublethal effects of azadirachtin on the bumblebee Bombus terrestris (Hymenoptera: Apidae)

Embryonic differentiation of serotonin‐containing neurons in the enteric nervous system of the locust (Locusta migratoria)

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