Effects of Autofluorescence Imaging on Detection and Treatment of Early Neoplasia in Patients With Barrett's Esophagus

Boerwinkel, David F.; Holz, Jasmin A.; Kara, Mohammed A.; Meijer, Sybren L.; Wallace, Michael B.; Song, Louis–Michel Wong Kee; Ragunath, Krish; Wolfsen, Herbert C.; Iyer, Prasad G.; Wang, Kenneth K.; Weusten, Bas L.; Aalders, Maurice C. G.; Curvers, Wouter L.; Bergman, Jacques

doi:10.1016/j.cgh.2013.10.013

Cited by 42 publications

(24 citation statements)

References 19 publications

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“…Detailed inspection with NBI reduced this false positive rate to 26%. A recent analysis of data from clinical trials, detection of lesions by AFI has little effect on the diagnosis of early stage neoplasia or on therapeutic decision making (2%) suggesting limited role of this technique in routine surveillance or management of patients with BE (72) In the last few decades, there has been increasing scientific interest in identifying clinical, molecular or genetic biomarkers to predict the development of neoplastic lesions of BO. In a recent cross-sectional prospective multicenter study involving 157 patients, AFI directed biopsies were combined with a biomarker panel and compared with the standard surveillance protocol for detection of dysplasia.…”

Section: Autofluorescencementioning

confidence: 98%

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

González-Haba

Waxman

2015

Best Practice & Research Clinical Gastroenterology

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Section: Autofluorescencementioning

confidence: 98%

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

González-Haba

Waxman

2015

Best Practice & Research Clinical Gastroenterology

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“…Initial experience of AFI demonstrated very high sensitivity but high false positive rates as well, and thus, NBI was incorporated into the strategy to decrease the false positive rate [22,23]. However, the use of AFI for detection alone has limited value in patients with BE [24]. These AFI-targeted areas in Barrett's may provide high yield specimens for additional tissue analysis [25•].…”

Section: Autofluorescence Imaging and Trimodal Imagingmentioning

confidence: 99%

Endoscopic Imaging

Konda

2015

Curr Treat Options Gastro

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The most important tools are the eye and the brain. A detailed white-light high-resolution examination and ability to recognize subtle lesions provide the foundation of the ability to detect lesions in the gastrointestinal tract. Novel technologies are now available to provide additional information with the goals of detection, delineation, or classification often with a focus on neoplasia in the gastrointestinal tract. The observer using these new tools must still recognize, interpret, and then make a clinically relevant conclusion. Therefore, the assessment of these tools may focus on both the technical feasibility to use the respective equipment to obtain an image and then also the associated cognitive-based criteria for image interpretation.

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“…fluorophores) such as collagen, nicotinamide adenine dinucleotide (NAD), flavinor porphyrins, when they are excited with ultraviolet light (<400 nm) or short wavelength light (mostly blue). Autofluorescence is influenced by changes in tissue architecture, the biochemical environment, metabolic status and light absorption properties (determined by haemoglobin concentration) -which occur mainly in neoplasia, inflammation and also ischaemia [15][16][17]. If mucosa or the epithelial layer are thickened autofluorescence is also influenced [18].…”

Section: Autofluorescence Imagingmentioning

confidence: 99%

“…• neovascularization, which induces increased haemoglobin concentration that will absorb the autofluorescence light [15][16][17][18][19][20].…”

Section: Autofluorescence Imagingmentioning

confidence: 99%

Advanced Endoscopic Imaging Techniques for the Study of Colonic Mucosa in Patients with Inflammatory Bowel Disease

Ştefănescu

Pereira

Filip

et al. 2016

Romanian Journal of Internal Medicine

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Background. Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBD) associated with colorectal cancer risk in long-standing diseases. In order to assess the colonic mucosa and to discover dysplastic or neoplastic lesions, advanced endoscopic techniques are needed. Such techniques are detailed in this review: chromoendoscopy, autofluorescence imaging (AFI), narrow band imaging (NBI), i-SCAN, Fujinon Intelligent Color Enhancement (FICE) and confocal laser endomicroscopy (CLE).Aim. The aim of the review is to describe and establish the clinical impact of advanced endoscopic techniques, that could be used in IBD patients'examination in order to assess mucosal healing, microscopic inflammation, dysplasia or neoplasia.Materials and Methods. A literature research about new endoscopic approaches of patients with IBD was made. Results.A lot of studies have been performed to reveal which imaging technique might be used for IBD surveillance. Regarding dysplasia or neoplasia detection and mucosal healing or inflammation assessment, CE proved to be superior to white light endoscopy (WLE), while NBI and AFI did not show an encouraging result. I-SCAN did not improve the colonoscopy quality while FICE has been used in a few studies. CLE could be used to characterize a lesion, providing the same results as conventional histology.Conclusion. At the moment, CE is the only technique which has been included in guidelines for IBD surveillance. CLE can be used to assess any lesion detected with WLE during surveillance, while the other imaging techniques require more studies to determine their efficacy or inefficacy.

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Effects of Autofluorescence Imaging on Detection and Treatment of Early Neoplasia in Patients With Barrett's Esophagus

Cited by 42 publications

References 19 publications

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

Endoscopic Imaging

Advanced Endoscopic Imaging Techniques for the Study of Colonic Mucosa in Patients with Inflammatory Bowel Disease

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