Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

González-Haba, Mariano; Waxman, Irving

doi:10.1016/j.bpg.2015.05.014

Cited by 2 publications

(2 citation statements)

References 86 publications

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“…The accepted standard for tissue acquisition for detecting dysplasia is the Seattle protocol, where four-quadrant forceps biopsies are taken every 1–2 cm throughout the length of the Barrett’s esophagus segment, which is characterized by salmon-colored mucosa [Levine et al 1993]. Although this approach can increase the yield of diagnosis of early neoplasia compared with other sampling methods, it is prone to sampling error and is both time consuming and costly [Falk et al 1999; Gonzalez-Haba and Waxman, 2015]. Therefore, advanced imaging technology in Barrett’s esophagus to identify ‘red flag lesions’ is needed to reduce or even eliminate random biopsies and focus sampling instead on targets suspicious for dysplasia and neoplasia.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, advanced imaging technology in Barrett’s esophagus to identify ‘red flag lesions’ is needed to reduce or even eliminate random biopsies and focus sampling instead on targets suspicious for dysplasia and neoplasia. Advanced imaging techniques are coined ‘red flag technology’ because lesions detected draw the attention of the endoscopist to targets for sampling or even endoscopic removal [Gonzalez-Haba and Waxman, 2015].…”

Section: Introductionmentioning

confidence: 99%

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The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

Trindade

Smith

Pleskow

2016

Therap Adv Gastroenterol

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Advanced imaging techniques used in the management of Barrett's esophagus include electronic imaging enhancement (e.g. narrow band imaging, flexible spectral imaging color enhancement, and i-Scan), chromoendoscopy, and confocal laser endomicroscopy. Electronic imaging enhancement is used frequently in daily practice, but use of the other advanced technologies is not routine. High-definition white light endoscopy and random four quadrant biopsy remain the standard of care for evaluation of Barrett's esophagus; this is largely due to the value of advanced imaging technologies not having been validated in large studies or in everyday practice. A new advanced imaging technology called volumetric laser endomicroscopy is commercially available in the United States. Its ease of use and rapid acquisition of high-resolution images make this technology very promising for widespread application. In this article we review the technology and its potential for advanced imaging in Barrett's esophagus.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

Trindade

Smith

Pleskow

2016

Therap Adv Gastroenterol

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Evaluation of NinePoint Medical’s Nvision VLE device for gastrointestinal applications

Mosko

Pleskow

2017

Expert Review of Medical Devices

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The incidence of esophageal adenocarcinoma (EAC) has increased over the last few decades. With a known precursor lesion, Barrett's esophagus, this remains a target for screening and surveillance with the goal of detecting and providing curative treatment for early neoplasia. Areas covered: Current surveillance techniques rely on white light endoscopy and random tissue sampling which is time consuming, costly and prone to sampling error. Volumetric laser endomicroscopy (VLE), a second-generation optical coherence technology, has emerged as an advanced imaging modality with the potential to improve dysplasia detection, surveillance and subsequently prevent esophageal adenocarcinoma. This review will focus on the use of VLE for advanced imaging of Barrett's esophagus and summarize its current and potential uses elsewhere in the GI tract. Expert commentary: NinePoint's VLE imaging device enables imaging of large segments of BE facilitating identification of luminal and subsurface abnormalities that may have otherwise been missed. Its diagnostic accuracy is improving and laser-marking system adds the capacity for accurate VLE-histologic correlation. With the adoption of dysplasia scoring systems that utilize very few VLE imaging features, inexperienced endoscopists will likely be able to pick out areas concerning for dysplasia to target therapy.

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Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

Cited by 2 publications

References 86 publications

The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

Evaluation of NinePoint Medical’s Nvision VLE device for gastrointestinal applications

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