Abstract:The effects of p-chlorophenylalanine, an inhibitor of serotonin synthesis, indomethacin, an inhibitor of prostaglandin synthesis, cyproheptadine, a serotonin, bradykinin and histamine antagonist, were assessed separately and in combination with chloroquine (CQ) in Vom strains of Swiss albino mice (18-22 g) of either sex infected intraperitoneally with 1 x 10(7) Plasmodium yoelii nigeriensis-induced malaria. As prophylactic, these agents reduced from 31.9 +/- 4.5 to 16.1 +/- 8.1% the level of parasitemia relati… Show more
“…It has been acknowledged that most of the trials that have been performed were on rodents that shows ofcourse great similarity with human but certain complications were observed such as, there was no fever suffering (Hyperthermia) due to malaria in rodents unlike human [70] and the antitumor effects are more long-lasting in rodents, upto a month, which illustrates that infectious period is directly proportional to the effect on tumor growth inhibition. While the benign malaria in human was observed to cause hyperthermia at acute phase and the malaria parasite could survie for years in chronic stages if the treatment is not provided.…”
Section: Limitations Of Plasmodium Immunotherapeutic Vaccinementioning
Cancer is one of the most death leading disease across the globe because of the unavailability of innocuous treatment strategy for cancer control so far but while having comparative study with malaria, it was found that there is some resemblance within the physiological conditions of the body as well as some antagonistic effects. Plasmodium is a parasitic microbe that is familiar for causing malaria within the animals and by thorough study, the immunotherapeutic potential of this organism was found against cancer as it consists of some tumorassociated antigens (TAAs) that favors the body in combating tumor by inducing immunomodulation and causing certain advantageous physiological changes.
“…It has been acknowledged that most of the trials that have been performed were on rodents that shows ofcourse great similarity with human but certain complications were observed such as, there was no fever suffering (Hyperthermia) due to malaria in rodents unlike human [70] and the antitumor effects are more long-lasting in rodents, upto a month, which illustrates that infectious period is directly proportional to the effect on tumor growth inhibition. While the benign malaria in human was observed to cause hyperthermia at acute phase and the malaria parasite could survie for years in chronic stages if the treatment is not provided.…”
Section: Limitations Of Plasmodium Immunotherapeutic Vaccinementioning
Cancer is one of the most death leading disease across the globe because of the unavailability of innocuous treatment strategy for cancer control so far but while having comparative study with malaria, it was found that there is some resemblance within the physiological conditions of the body as well as some antagonistic effects. Plasmodium is a parasitic microbe that is familiar for causing malaria within the animals and by thorough study, the immunotherapeutic potential of this organism was found against cancer as it consists of some tumorassociated antigens (TAAs) that favors the body in combating tumor by inducing immunomodulation and causing certain advantageous physiological changes.
“…The importance of cytokines in disease has been illustrated in studies by Iwalewa and Agbani (2004) and Iwalewa et al (2007) (submitted paper). These studies were conducted to inhibit the autacoids released before and during malaria infection and diabetes disorders respectively.…”
Section: Evidence Showing the Involvement Of Cytokines In Diseasesmentioning
confidence: 99%
“…The molecular mechanism of chronic inflammation, its prevention and mitigation with phytomedicines have been intensively evaluated by our group over the past ten years (McGaw et al, 1997;Eloff et al, 2001;McGaw et al, 2001;Iwalewa et al, 2003;Omisore et al, 2004;Iwalewa and Agbani, 2004;Iwalewa et al, 2005;Omisore et al, 2005;Iwalewa et al, 2006;Idowu et al, 2006;Naidoo et al, 2006;Angeh et al, 2007). Epidemiological data suggest that lower incidences of certain chronic dis-*Corresponding author.…”
Great interest in herbal medicine as a potential source of phytopharmaceuticals has created the need to review common factors responsible for major diseases and body disorders. This review shows one such common factor in inflammation and the role herbal medicine can play. Traditional medicinal herbal remedies in the southern African region have long been used to treat various pain-or inflammation-related symptoms. Although the precise mechanisms of action of many herbal drugs have yet to be determined, some of them have been shown to exert anti-inflammatory and/or antioxidant effects in a variety of cells in the human and animal bodies. There is increasing evidence to indicate that both peripheral and central nervous system cells play a prominent role in the chronic inflammatory responses in the body system and anti-inflammatory herbal medicine and its constituents are being proved to be a potent protector against various pro-inflammatory mediators in diseases and disorders. These mediators have therefore been suspected of being the functional basis of diseases and disorders. The structural diversity of these medicinal herbs makes them a valuable source of novel lead compounds against the therapeutic molecular targets, cytokines and mediators, that have been newly discovered by the platforms of genomics, proteomics, metabolomics and highthroughput technologies. This article reviews the basic mechanisms of inflammation and the potential of 123 southern African plant species to be effective as chronic inflammatory disease preventive agents. With one third of these species there are no indications of the chemical composition, indicating possible subjects for further research.
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