Effects of auditory deprivation on the development of auditory sensitivity in albino rats

Batkin, Stanley; Groth, Hilde; Watson, Jdg; Ansberry, Merle

doi:10.1016/0013-4694(70)90227-0

Cited by 57 publications

(11 citation statements)

References 29 publications

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“…Keywords microgravity; development; fetus; maternal; otoliths Sensory deprivation during ontogenesis has proven to be a highly effective tool for investigating sensory development. Studies employing dark-rearing (Hubel & Wiesel, 1982), plugging the ears (Batkin, Groth, Watson, & Ansberry, 1970), obstructing the nares (Kucharsky & Hall, 1987), or eliminating tactile input normally supplied by the vibrissae (Woolsey & Wann, 1976) have yielded important insights into how stimulation plays an active, formative role during sensory ontogenesis. Sensory deprivation during early life produces enduring deficits in sensory functions.…”

Section: Introductionmentioning

confidence: 99%

Orbital spaceflight during pregnancy shapes function of mammalian vestibular system.

Ronca

Fritzsch

Bruce

et al. 2008

Behavioral Neuroscience

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Pregnant rats were flown on the NASA Space Shuttle during the early developmental period of their fetuses' vestibular apparatus and onset of vestibular function. The authors report that prenatal spaceflight exposure shapes vestibular-mediated behavior and central morphology. Postflight testing revealed (a) delayed onset of body righting responses, (b) cardiac deceleration (bradycardia) to 70°h ead-up roll, (c) decreased branching of gravistatic afferent axons, but (d) no change in branching of angular acceleration receptor projections with comparable synaptogenesis of the medial vestibular nucleus in flight relative to control fetuses. Kinematic analyses of the dams' on-orbit behavior suggest that, although the fetal otolith organs are unloaded in microgravity, the fetus' semicircular canals receive high levels of stimulation during longitudinal rotations of the mother's weightless body. Behaviorally derived stimulation from maternal movements may be a significant factor in studies of vestibular sensory development. Taken together, these studies provide evidence that gravity and angular acceleration shape prenatal organization and function within the mammalian vestibular system. Keywords microgravity; development; fetus; maternal; otoliths Sensory deprivation during ontogenesis has proven to be a highly effective tool for investigating sensory development. Studies employing dark-rearing (Hubel & Wiesel, 1982), plugging the ears (Batkin, Groth, Watson, & Ansberry, 1970), obstructing the nares (Kucharsky & Hall, 1987), or eliminating tactile input normally supplied by the vibrissae (Woolsey & Wann, 1976) have yielded important insights into how stimulation plays an active, formative role during sensory ontogenesis. Sensory deprivation during early life produces enduring deficits in sensory functions. For example, clinical observations (Peters, Litovsky, Parkinson, & Lake, 2007;Rubinstein & Miller, 1999) have shown that proper acoustic input is critical for the development of hearing; delayed provision of a cochlear implant in children can prevent acquisition of proper understanding of spoken words. Similarly, understanding the roles of early stimulation has augmented clinical approaches in the treatment of visual impairments (Maurer, Lewis, Brent, & Levin, 1999). In contrast to other sensory systems, our understanding of neurovestibular ontogeny has progressed slowly, due, in part, to the historic difficulty of depriving young organisms of the Earth-constant stimulus of gravity. A growing number of techniques are proving their utility for depriving the immature mammalian vestibular system of sensory input. For example, the semicircular canals (Geisler & Gramsbergen, 1998; Correspondence concerning this article should be addressed to April E. Ronca, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157. E-mail: aronca@wfubmc.edu. Relatively little work has focused on the emergence of vestibular function. Yet within the sequentially fixed, highly conserve...

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Section: Introductionmentioning

confidence: 99%

Orbital spaceflight during pregnancy shapes function of mammalian vestibular system.

Ronca

Fritzsch

Bruce

et al. 2008

Behavioral Neuroscience

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“…However, by 48 hours and 3 weeks after deprivation, the cortical response thresholds appeared similar to normal controls. In spite of this reported rapid return toward normal thresholds, the authors state that their results "reinforce the clinical impressions of the importance of adequate early auditory stimulation in children with hearing difficulties" (Batkin et al, 1970).…”

Section: Physiological Studiesmentioning

confidence: 58%

“…Relatively few physiological studies have been reported on either sounddeprived or conductive-loss animals. Batkin et al (1970) studied tone-produced cortical evoked responses in sounddeprived rats. In this experiment, nursing mothers were rendered avocal by laryngeal cauterization and, after weaning, the young rats were reared for 8 months in individual cages in a sound attenuated chamber placed in an extinct volcano crater.…”

Section: Physiological Studiesmentioning

confidence: 99%

Effects of Neonatal Sound Deprivation in Animal Research

Webster¹

1982

Semin Hear

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“…One deficit ~ound in deprived animals is poorer hearing thresholds (Batkin, Groth, Watson and Ansberry, 1970).…”

Section: Review Of the Literature Sensory Deprivation During Criticalmentioning

confidence: 99%

Central auditory processing in children with a history of chronic middle ear problems

Schnabel

2000

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The purpose of this study was to investigate the Qentral auditory processing of children who had sustained chronic middle ear problems during their early language-learning years. A 60% compressed recording of the NU-6 speech discrimination word lists was administered to twenty eight and nine year old normal hearing public school children, reported by their parents to have qad repeated middle ear problems during their early years, and to twenty control subjects matched for age from the same public schopl classes. · Differences in compressed and uncompressed word discrimination scores between the experimental and control groups were not found to be statistically significant. These results indicate that the experimental subjects' ability to process compressed speech was not impaired by early middle ear difficulties. The alternative was suggested that if these children actually sustained central damage due to distorted or degraded input during their hearing deficit episodes, then such effects may be neutralized by subsequent auditory exerience and neurological maturity. A significant difference for both groups of children was noted between scores obtained with NU-6 lists 2A and 3A at 60% compression. While apparently equivalent in the uncompressed form, list 3 was found to ~e significantly ~ore difficult than list 2 when compressed. Implications for further research are discussed.

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Effects of auditory deprivation on the development of auditory sensitivity in albino rats

Cited by 57 publications

References 29 publications

Orbital spaceflight during pregnancy shapes function of mammalian vestibular system.

Orbital spaceflight during pregnancy shapes function of mammalian vestibular system.

Effects of Neonatal Sound Deprivation in Animal Research

Central auditory processing in children with a history of chronic middle ear problems

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