Effects of Atracurium Added to Local Anesthetics on Akinesia in Peribulbar Block

Küçükyavuz, Zuhal; Arici, Kemal M.

doi:10.1097/00115550-200209000-00008

Cited by 18 publications

(13 citation statements)

References 16 publications

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“…The findings of their study showed that the addition of vecuronium improves lid and globe akinesia without side effects. Similarly, Kucukyavuz and Arici [10] added 5 mg atracurium to a mixture of bupivacaine-lidocaine without hyaluronidase and obtained comparable results.…”

Section: Discussionmentioning

confidence: 92%

“…To overcome these limitations, many adjuvant drugs such as adrenaline, sodium bicarbonate, hyaluronidase, clonidine, and opioids [4][5][6][7][8] have been added to the local anesthetic mixture used for peribulbar block to augment its efficacy and hasten its speed of onset; however, their effects have been variable. Neuromuscular blocking drugs, such as vecuronium [9] and atracurium [10], have also been added to the local anesthetic mixture and have been shown to improve the quality of peribulbar anesthesia. Atracurium, however, has histaminereleasing properties and could result in undesirable local hyperemia.…”

Section: Introductionmentioning

confidence: 99%

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Rocuronium versus dexmedetomidine as an adjuvant to local anesthetics in peribulbar block: A double blind randomized placebo controlled study

Bakr

Abdelaziz

2017

Egyptian Journal of Anaesthesia

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a b s t r a c tObjective: To compare the use of rocuronium with that of dexmedetomidine as an adjuvant to the local anesthetic mixture in peribulbar anesthesia for cataract surgery. Design: A double blind, prospective, randomized controlled study. Methods: Ninety patients with cataract in the age group 18-80 years of American Society of Anesthesiologists (ASA) physical status I-III scheduled for elective cataract surgery under regional anesthesia were randomly divided into three groups; Group C (control) received peribulbar anesthesia using a mixture of 4 ml lidocaine 2%, 4 ml bupivacaine 0.5%, and 1 ml normal saline. Group R received a mixture of 4 ml lidocaine 2%, 4 ml bupivacaine 0.5%, and 0.06 mg/kg rocuronium (maximum 5 mg) in 1 ml saline.Group D received a mixture of 4 ml lidocaine 2%, 4 ml bupivacaine 0.5%, and dexmedetomidine 50 lg (1 ml). Patients were assessed for onset and duration of corneal anesthesia and globe akinesia, postoperative pain using visual analog score (VAS), intraocular pressure (IOP), and sedation level using modified Ramsay sedation score (RSS). Patient and surgeon satisfaction score were also assessed. Results: Corneal anesthesia was achieved more rapidly in groups D and R than group C (P < 0.01). Akinesia was achieved more rapidly in the group R than both group D and group C. Akinesia was achieved more rapidly in group D than the control group. Intraocular Pressure was significantly lower in group D compared to both the control group and group R. Ramsay sedation score was significantly higher in group D compared to both the control group and D. Patient and surgeon satisfaction was significantly higher in group R and D compared to the control group. Conclusion: Adding 5 mg rocuronium to local anesthetic mixture provides more rapid onset of corneal and globe akinesia than 50 lg dexmedetomidine. Adding dexmedetomidine decreases IOP and provides sedation.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Rocuronium versus dexmedetomidine as an adjuvant to local anesthetics in peribulbar block: A double blind randomized placebo controlled study

Bakr

Abdelaziz

2017

Egyptian Journal of Anaesthesia

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“…The concentration of AB was established empirically, as this is, to the authors’ knowledge, the first work concerning local intraurethral administration of this compound. The concentration of the AB solution (0·5 mg/mL) was the same used in a previous study to improve local peribulbar anaesthesia for ophthalmic surgery in humans (Küçükyavuz and Arici ).…”

Section: Methodsmentioning

confidence: 99%

Effect of intraurethral administration of atracurium besylate in male cats with urethral plugs

Galluzzi

Rensis

Menozzi

et al. 2012

J of Small Animal Practice

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“…Small doses of muscle relaxant may enhance akinesia, but concern has been expressed about their potential risk for systemic effects. 67 Opioids do not appear to be more efficient via a regional ophthalmic route than via systemic administration. 68 Warming the local anesthetic may decrease pain on injection and enhance block efficacy, but its benefit appears clinically irrelevant.…”

Section: Local Anesthetics and Adjuvant Agentsmentioning

confidence: 99%

Regional anesthesia for eye surgery

Ripart

Nouvellon

Chaumeron

2005

Regional Anesthesia and Pain Medicine

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Effects of Atracurium Added to Local Anesthetics on Akinesia in Peribulbar Block

Cited by 18 publications

References 16 publications

Rocuronium versus dexmedetomidine as an adjuvant to local anesthetics in peribulbar block: A double blind randomized placebo controlled study

Rocuronium versus dexmedetomidine as an adjuvant to local anesthetics in peribulbar block: A double blind randomized placebo controlled study

Effect of intraurethral administration of atracurium besylate in male cats with urethral plugs

Regional anesthesia for eye surgery

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