Effect of intraurethral administration of atracurium besylate in male cats with urethral plugs

Galluzzi, Francesco; Rensis, F. De; Menozzi, Alessandro; Spattini, Gian Claudio

doi:10.1111/j.1748-5827.2012.01239.x

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…Use of atracurium infusion should be considered by clinicians managing spinal patients, particularly if urinary retention is a problem. Urethral infusion of atracurium has also been found to facilitate the clinical management of urethral plugs in male cats (Galluzzi and others 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Atracurium, which is chemically stable in saline solution (Pramar and others 1996), has been used successfully in cats via intraurethral administration for the clinical management of urethral plugs (Galluzzi and others 2012). Muscle weakness or any other side effect related to atracurium administration was not detected in that study.…”

Section: Introductionmentioning

confidence: 99%

“…Atracurium besylate is a curare derivative that acts as a neuromuscular blocking agent by antagonising acetylcholine at the nicotinic receptors in the neuromuscular junction and therefore inducing paralysis of striated muscles (Martinez and Keegan 2007). Atracurium, which is chemically stable in saline solution (Pramar and others 1996), has been used successfully in cats via intraurethral administration for the clinical management of urethral plugs (Galluzzi and others 2012). Muscle weakness or any other side effect related to atracurium administration was not detected in that study.…”

Section: Introductionmentioning

confidence: 99%

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Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a randomised trial

et al. 2015

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The aim of this randomised trial was to assess the effect of urethral infusion of atracurium besylate in dogs and cats with signs of urinary retention secondary to lesions affecting spinal cord segments T3-L3. Eighteen dogs and six cats with urinary retention were examined and scored before treatment on the degree of difficulty of inducing bladder emptying by manual bladder compression. Animals were subsequently treated in a blinded fashion by the same operator with urethral infusion of 2-4 ml of either a solution of 0.5 mg/ml of atracurium (treatment group) or placebo (control group) and, after five minutes, a second attempt was made to induce bladder emptying by manual compression and a post-treatment score assigned. Pretreatment scores did not differ between the treatment and control groups (5.6±0.8 v 6.2±0.7, respectively; P=0.22); however, post-treatment scores were significantly lower in the treatment group compared with the control group (2.9±0.4 v 5.9±0.3; P<0.05). Urethral infusion of atracurium facilitates manual bladder expression in dogs and cats with urinary retention secondary to spinal cord injuries. No side effects were recognised.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a randomised trial

et al. 2015

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“…Sterile lubricant should be used and lidocaine can be mixed with this to provide analgesia within the urethra. Some authors also suggest instilling a neuromuscular blocker into the urethra, such as atracurium besilate (Galluzzi and others 2012). An assistant should extrude the penis from the prepuce.…”

Section: Methods Of Urethral Unblocking and Catheterisation In A Prim...mentioning

confidence: 99%

Approach to urethral obstruction in cats. Part 2: catheterising and postobstruction management

Breheny¹,

Blacklock²,

Gunn‐Moore³

2022

In Practice

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Background: Catheterisation is the key definitive emergency procedure in relieving urethral obstruction. However, ensuring that the patient is stable to tolerate the procedure and having a plan in place if placement is challenging is also essential.Aim of the article: This is the second article in a three-part series. The aim of this article is to summarise urethral catheterisation, and immediate postcatheterisation management. The first article discussed presentation and stabilisation (Breheny and others ), while the third will focus on home management to prevent recurrent obstruction and on addressing underlying feline idiopathic cystitis. Craig Brehenyquali ed from the University of Edinburgh in 2011. A er three years in general practice in the north east, he returned to Edinburgh for a residency in internal medicine and was awarded his diploma in 2019. He is now a senior lecturer as part of the emergency and critical care service at the Royal (Dick) School of Veterinary Studies (R[D]SVS).

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“…More recently, Galluzzi et al . (2012) demonstrated that intraurethral administration of a non‐depolarising neuromuscular blocking drug, atracurium, before retrograde flushing, facilitates the clinical management of urethral plugs by reducing the overall time needed to remove the obstruction. They reported no adverse reactions from the atracurium administration.…”

Section: Introductionmentioning

confidence: 99%

Generalised neuromuscular blockade after intraurethral administration of atracurium besilate in a male cat with urethral obstruction

Casoria¹,

Felisberto²,

Auckburally³

et al. 2023

J of Small Animal Practice

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A 4‐year‐old, entire, male, domestic long‐haired cat was presented with an acute history of stranguria and dysuria and diagnosed with urolithiasis causing urethral obstruction. The patient was induced to general anaesthesia and several unsuccessful attempts to flush the uroliths retrogradely towards the bladder were made. An intraurethral administration of the neuromuscular blocking agent atracurium was performed as it has been reported to facilitate urethral catheterisation without any side effects. Respiratory arrest developed after 15 minutes from atracurium administration, which was promptly recognized and treated with mechanical ventilation. The absence of muscle contraction in response to a nerve stimulation confirmed a generalised muscle blockade. Approximately 35 minutes after, a muscle response to nerve stimulation appeared. Neostigmine combined with glycopyrrolate was administered resulting in complete recovery from neuromuscular blockade. In conclusion, the use of intraurethral atracurium can result in systemic absorption of the drug with subsequent generalised neuromuscular blockade.

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Effect of intraurethral administration of atracurium besylate in male cats with urethral plugs

Abstract: The results of this study indicate that in adult male cats with urethral plugs, urethral administration of atracurium besylate increases the proportion of animals in which the obstruction is removed at the first attempt and reduces the time required to remove the urethral plugs.

Cited by 8 publications

References 29 publications

Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a randomised trial

Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a randomised trial

Approach to urethral obstruction in cats. Part 2: catheterising and postobstruction management

Generalised neuromuscular blockade after intraurethral administration of atracurium besilate in a male cat with urethral obstruction

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