Effects of Atopic Syndrome on Keratoconus

Shajari, Mehdi; Eberhardt, Emanuel; Müller, Michael; Khateeb, Ghada Al; Friderich, Stefan; Remy, Matthias; Kohnen, Thomas

doi:10.1097/ico.0000000000000935

Cited by 34 publications

(24 citation statements)

References 36 publications

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“…It can therefore be concluded that atopy is an early indicator of KC and that patients with a history of atopy require regular ophthalmological examinations. It was also observed that the corneal optical density of the anterior 120 µm of the cornea was higher in the group with atopy (21.92 ±4.65 vs. 20.74 ±4.68, p = 0.016) [29].…”

Section: Advances In Dermatology and Allergology 2 April / 2020mentioning

confidence: 76%

Ophthalmic manifestations of atopic dermatitis

Pietruszyńska¹,

Zawadzka-Krajewska²,

Duda³

et al. 2020

pdia

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Atopic dermatitis is a chronic condition of complex etiology, whose clinical course involves remission and recurrence. It is not an isolated disease entity affecting only the skin, but one that co-occurs with disorders of other organs. Numerous literature reports have long confirmed the relationship between the disorder and a growing number of ophthalmic manifestations such as keratoconus and retinal detachment. Further studies are required to establish the cause of correlations and to allow for implementation of appropriate prophylaxis and treatment. The aim of the present paper is to review published literature regarding the correlation between atopic dermatitis and ophthalmic manifestations in adults and children.

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Section: Advances In Dermatology and Allergology 2 April / 2020mentioning

confidence: 76%

Ophthalmic manifestations of atopic dermatitis

Pietruszyńska¹,

Zawadzka-Krajewska²,

Duda³

et al. 2020

pdia

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show abstract

“…Contrary results have been reported in the literature with regards to whether or not atopy is associated with KC pathogenesis (Lowell and Carroll, 1970), as KC individuals appear to rub their eyes much more frequently than healthy individuals (Galvis et al, 2017). Previous studies have reported differences in topographic measurements (Shajari et al, 2016) as well as differences in progression between KC patients, with and without atopy (King et al, 1999). Interestingly, the latter study found that KC patients with atopy tend to have faster KC progression and more frequent refractive and immunologic complications leading to an earlier need for keratoplasty.…”

Section: Pathobiology Of Keratoconusmentioning

confidence: 99%

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Sharif

Bak‐Nielsen

Hjortdal

et al. 2018

Progress in Retinal and Eye Research

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Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle. Surprisingly, the role of sex hormones in corneal diseases and KC has been largely neglected. Prolactin-induced protein, known to be regulated by sex hormones, is a new KC biomarker that has been recently proposed. Studies herein discuss the role of sex hormones as a control mechanism for KC onset and progression and evidence supporting the view that prolactin-induced protein is an important hormonally regulated biomarker in KC is discussed.

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“…8 Faculty of Medicine of the Military Medical academy, University of Defense, Belgrade, Serbia. 9 The Cleveland Clinic, Clevelan OH, USA. 10 Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil.…”

Section: Fundingmentioning

confidence: 99%

“…Patients who intensely rub their eyes (e.g. those with Down Syndrome and atopic patients are at higher risk of developing keratoconus [ 4 , 7 – 9 ]. The reasons to rub their eyes are manifold: itchiness in atopic conjunctivitis represents one of the most common causes of eye rubbing [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the mechanical forces applied during eye rubbing

Hafezi

Pajic

et al. 2020

BMC Ophthalmol

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Background: To determine the average amount of mechanical forces applied to the lids of keratoconus patients during eye rubbing. Methods: Fifty-seven patients (41 male, 16 female, average age 34.8 years) with a clinically and topographically diagnosed keratoconus and a history of eye rubbing were prospectively asked to perform their individual eye rubbing movement on a high-precision balance. The type of eye-rubbing movement and the force applied, represented in newtons (N), were recorded and analyzed. Results: We detected three different types of eye rubbing. Rubbing with the fingertip was most frequent (51%), followed by rubbing with the knuckle (44%) and rubbing with the fingernail (6%). Each type of eye rubbing showed different average forces, with knuckle type eye rubbing applying significantly more force (9.6 ± 6.3 N) on the lids than fingertip (4.3 ± 3.1 N) and fingernail (2.6 ± 3.3 N) types (p < 0,001 and p = 0,016, respectively). Conclusions: There were major variations in the force exerted on the lids, depending on the type of eye rubbing employed. This data will help determine the forces that need to be applied in future experimental eye rubbing models.

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Effects of Atopic Syndrome on Keratoconus

Cited by 34 publications

References 36 publications

Ophthalmic manifestations of atopic dermatitis

Ophthalmic manifestations of atopic dermatitis

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Assessment of the mechanical forces applied during eye rubbing

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