Effects of Astragali Radix Extract on Carcinogenesis, Cytokine Production, and Cytotoxicity in Mice Treated with a Carcinogen, N-Butyl-N-butanolnitrosoamine

Kurashige, Satonori; Akuzawa, Yuki; Endo, Fumio

doi:10.3109/07357909909011714

Cited by 23 publications

(10 citation statements)

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“…However, by changing the environment surrounding HIV in the human body, the emergence of an aberrant strain of HIV can be controlled and anti-virus activation by antibodies in the human body can be enhanced. Also, by activating mechanisms in the human body such as cytokine and chemokine, anti-HIV effects may emerge (Cocchi et al, 2000;Detheux et al, 2000;Ferbas et al, 2000;Gong et al, 1998;Kaneko et al, 1999;Kurashige et al, 1999;Ono et al, 1990;Rininger et al, 2000;Smolarz and Skwarek, 1999;Zhao et al, 1999). For the moment, we think that point (2) is the most likely mechanism.…”

Section: Discussionmentioning

confidence: 93%

The Effects of Long-Term Herbal Treatment for Pediatric AIDS

et al. 2002

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This paper presents our long-term (1992-2000) treatment of pediatric Acquired Immune Deficiency Syndrome (AIDS) patients (maximum 100 children, last three years 65) using native herbal remedies in a voluntary medical assistance program in Constanta, Romania. We primarily report the progress of 10 children at a facility called the "House of Tomorrow" and three other facilities. The long-term (8 years and 8 months) treatment contributed to a drop of the amount of Human Immunodeficiency Virus Ribonucleic Acids (HIV-RNA) below the measurable level for 9 out of 10 patients at the "House of Tomorrow." Furthermore, the treatment led to preservation and increase of the cluster of differentiation (CD4) count, a remarkable decrease in mortality rate, as well as the maintenance of a good quality of life. It took one to three years for the beneficial effects of the treatment to emerge. No side-effects were recognized either clinically or biochemically, nor was there any emergence of drug-resistant strains of HIV as seen with anti-HIV chemical treatments. This paper also refers to which herbal remedies were used and their general mechanism of action.

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Section: Discussionmentioning

confidence: 93%

The Effects of Long-Term Herbal Treatment for Pediatric AIDS

et al. 2002

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“…Wei (2003) reported that cultured peripheral blood mononuclear cells collected from patients treated with astragalus root produced higher amounts of IFN-␥ and IL-2, which are recognized as Th1 cytokines. It was also demonstrated that AR specifically increased the production of IL-2 and IFN-␥ as well as the overall cytotoxic activity of lymphocytes from mice treated with a carcinogen called BBN (Kurashige, 1999). Gyokuheifusan of which AM is main component, significantly increased the production of IFN-␥ released by Ova-treated splenocytes to a much higher level (Fang, 2005).…”

Section: Discussionmentioning

confidence: 95%

Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition

Shen

Wang

et al. 2008

Journal of Ethnopharmacology

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“…Among the plants, Astragalus membranaceus markedly stimulated murine spleen cells to proliferate and suggested to be used clinically for the modulation of immune responses. Kurashige et al (1998Kurashige et al ( , 1999 studied the effects of a Chinese herbal drug named Shikaron and Astragalus Radix extract as the main component, on carcinogenesis, NK cell activity and the cytokine production of lymphocytes in mice treated with a carcinogen N-butyl-N -butanolnitrosoamine (BBN). They found a significantly lower incidence of urinary bladder carcinoma in mice treated with either 200 mg/kg/day of Shikaron or 10 mg/kg/day or more of Astragalus extract.…”

Section: Resultsmentioning

confidence: 99%