Effects of astaxanthin on dinitrofluorobenzene-induced contact dermatitis in mice

Abstract

Astaxanthin (AST) is known to exhibit antioxidative and antitumor properties, therefore, the present study investigated its other potential medical applications. AST was observed to exhibit anti‑allergic and anti‑inflammatory effects in a dinitrofluorobenzene (DNFB)‑induced contact dermatitis (CD) mouse model and RBL‑2H3 cell lines. The topical application of AST effectively inhibited the enlargement of ear thickness and increase in weight, which occurred following repeated application of DNFB. Furthermore, topical application of different concentrations of AST inhibited inflammatory hyperplasia, edema, spongiosis, and the infiltration of mononuclear cells and mast cells in the ear tissue. In addition, the levels of TNF‑α and IFN‑γ produced were decreased by application of AST in vivo, and treatment of RBL‑2H3 cells with AST inhibited the release of histamine and β‑hexosaminidase in vitro. Taken together, these data suggested that AST may be used to treat patients with allergic skin diseases through a mechanism, which may be associated with that involved in anti‑inflammatory or anti-allergic activities.

Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches

“…Polymeric nanoparticles, liposomes and cyclodextrins have been used to encapsulate AST, however, more efforts are needed to enhance the bioavailability of AST. This naturally occurring compound has a number of therapeutic and biological activities (figure 1) such as anti-oxidant [29,30], anti-inflammatory [31], anti-tumor [31], anti-diabetic [32] and hepatoprotective [33].…”

Mini-Revisão Sobre Os Carotenoides: Conceitos, Fontes E Atividades Biológicas

“…Pigmentos encontrados na maioria das frutas e vegetais, plantas, algas e bactérias resistência a insulina (NI et al, 2015), proteção do músculo liso vascular (CHEN et al, 2020), agente neuroprotetor contra a isquemia do nervo óptico (LIN et al, 2020), homeostase mitocondrial do cálcio (SZTRETYE et al, 2020), prevenção da osteoartrite (SUN et al, 2019), antioxidante e anti-envelhecimento (EREN et al, 2019), proliferação e migração de células cancerosas da mama in vitro (McCall et al, 2018), pigmentação do leite (MEZQUITA et al, 2015), tratamento da dermatite de contato (KIM et al, 2015), supressão de enfisema pulmonar (KUBO et al, 2019), proteção contra danos à retina (OTSUKA et al, 2016), prevenção de lesão pulmonar (CAI et al, 2019), além do uso como aditivos em cosméticos (TOMINAGA et al, 2012).…”

Mini-Revisão Sobre Os Carotenoides: Conceitos, Fontes E Atividades Biológicas

“…Os carotenóides de origem vegetal podem atuar como fotoprotetores, antioxidantes, atrativos de cor e precursores de hormônios vegetais em órgãos não fotossintéticos das plantas (MAOKA, 2020). Lima et al (2019) (LIU et al, 2018), prevenção e reversão da resistência a insulina (NI et al, 2015), proteção do músculo liso vascular (CHEN et al, 2020), agente neuroprotetor contra a isquemia do nervo óptico (LIN et al, 2020), homeostase mitocondrial do cálcio (SZTRETYE et al, 2020), prevenção da osteoartrite (SUN et al, 2019), antioxidante e anti-envelhecimento (EREN et al, 2019), proliferação e migração de células cancerosas da mama in vitro (McCall et al, 2018), pigmentação do leite (MEZQUITA et al, 2015), tratamento da dermatite de contato (KIM et al, 2015), supressão de enfisema pulmonar (KUBO et al, 2019), proteção contra danos à retina (OTSUKA et al, 2016), prevenção de lesão pulmonar (CAI et al, 2019), além do uso como aditivos em cosméticos (TOMINAGA et al, 2012).…”