Effects of Astaxanthin from Litopenaeus Vannamei on Carrageenan-Induced Edema and Pain Behavior in Mice

Abstract

Carrageenan produces both inflammation and pain when injected in mouse paws via enhancement of reactive oxygen species formation. We have investigated an effect of astaxanthin extracted from Litopenaeus vannamei in carrageenan-induced mice paw edema and pain. The current study demonstrates interesting effects from astaxanthin treatment in mice: an inhibition of paw edema induced in hind paw, an increase in mechanical paw withdrawal threshold and thermal paw withdrawal latency, and a reduction in the amount of myeloperoxidase enzyme and lipid peroxidation products in the paw. Furthermore the effect was comparable to indomethacin, a standard treatment for inflammation symptoms. Due to adverse effects of indomethacin on cardiovascular and gastrointestinal systems, our study suggests promising prospect of astaxanthin extract as an anti-inflammatory alternative against carrageenan-induced paw edema and pain behavior.

Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement ofERKandAKTsignalling pathway

“…In another study, it was shown that AST at the dose of 5 mg/kg, i.p, reduces von Frey mechanical hyperalgesia and at higher doses, 10 mg/kg, i.p., reduces both thermal and mechanical hypersensitivity in rats undergoing chronic constriction of the sciatic nerve via oxido‐inflammatory and NMDA receptor down‐regulation pathway (Sharma et al., ). In a model of carrageenan‐induced inflammatory pain, AST also indicates an efficacy comparable to indomethacin in relieving mechanical and thermal hyperalgesia (Kuedo, Sangsuriyawong, Klaypradit, Tipmanee, & Chonpathompikunlert, ).…”

“…One-way analysis of variance with Tukey post-hoc test was used. SCI, Spinal cord injury; AST, Astaxanthin (10 μl of 0.2 mM, intrathecal, 30 min post-injury); DMSO, dimethylsulfoxide thermal hyperalgesia (Kuedo, Sangsuriyawong, Klaypradit, Tipmanee, & Chonpathompikunlert, 2016).…”

Supplementation of astaxanthin and vitamin E in feed on the development of gonads white shrimp broodstock Litopenaeus vannamei Boone 1931

“…This suggests that the supplementation of astaxanthin and vitamin E in feed accelerate the gonad maturity in the shrimp broodstock. It is due to astaxanthin alleviate PGE2 (prostaglandin) hormone when the shrimp reaches the final gonad maturity (Kuedo et al, 2016). Therefore, the decrease of PGE2 (prostaglandin) hormones leads gonads to develop properly and the quality of eggs remain good due to lack of egg decay.…”

Anti-inflammatory and hepatoprotective potentials of the aerial parts of <i>Silene villosa</i> Caryophyllaceae methanol extract in rats

“…Carrageenan-induced paw edema in rats is one of the experimental animal model for exploring anti-inflammatory potential of extracts and other compounds [17]. Subcutaneous injection of carrageenan in the hind paw of rats induced local edema.…”