Effects of asiatic acid, an active constituent in Centella asiatica (L.): restorative perspectives of streptozotocin-nicotinamide induced changes on lipid profile and lipid metabolic enzymes in diabetic rats

Swapna, K.; Uddandrao, V. V. Sathibabu; Parim, Brahmanaidu; Ramavat, Ravindarnaik; Palaniyandi, Suresh S.; Ponmurugan, P.; Balakrishnan, Santhanaraj; Vadivukkarasi, S.; Nemani, Harishankar; Kallamadi, Prathap Reddy; Nivedha, P. R.; Saravanan, G.

doi:10.1007/s00580-019-02955-6

Cited by 10 publications

(5 citation statements)

References 27 publications

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“… 31 , 35 Several studies have shown that herbal compounds have hypoglycemic effects, significantly attenuate hyperinsulinemia and IR, and combat obesity. 24 , 25 , 36 Consistent with these studies, we found in this study that supplementation with phytoformulation significantly suppressed weight gain and fat deposition in obese rats. In addition, phytoformulation was also effective in reducing IR, hyperinsulinemia, and hyperglycemia induced by HFD.…”

Section: Discussionsupporting

confidence: 90%

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Uddandrao,

Chandrasekaran,

Saravanan

et al. 2024

Journal of Traditional and Complementary Medicine

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Section: Discussionsupporting

confidence: 90%

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Uddandrao,

Chandrasekaran,

Saravanan

et al. 2024

Journal of Traditional and Complementary Medicine

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“…Under the action of various phospholipases, glycerophospholipids are decomposed into lysolecithin, diacylglycerol, fatty acids, and phosphoric acid [27].…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

et al. 2020

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Ageing increases the occurrence and development of many diseases. Exercise is believed to be an effective way to improve ageing and skeletal muscle atrophy. However, many elderly people are unable to engage in active exercise. Whole-body vibration is a passive way of moving that is especially suitable for the elderly and people who find it inconvenient to exercise. Metabolomics is the systematic study of metabolic changes in small molecules. In this study, metabolomics studies were performed to investigate the regulatory effect of whole-body vibration on the skeletal muscles of ageing mice. After 12 weeks, we found that whole-body vibration had the most obvious effect on lipid metabolism pathways (such as linoleic acid, α-linolenic acid metabolism, glycerophospholipid metabolism pathways) in skeletal muscle of ageing mice. Through further research we found that whole-body vibration decreased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein in blood; decreased the lipid deposition in skeletal muscle; decreased the protein expression of monocyte chemoattractant protein-1 and interleukin-6; improved the protein levels of phosphorylated insulin receptor substrate-1, phosphate phosphoinositide 3-kinase and p-AKT; improved the protein levels of klotho; and decreased the protein expression of p53. These findings reveal that whole-body vibration might postpone senility by attenuating lipid deposition and reducing chronic inflammation and the insulin resistance of skeletal muscle.

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“…MI is associated with a distorted lipid metabolism. Lipids have been shown to be involved in the incidence of CVD via modification of the stability, structure, and composition of the cell membrane; Several CVDs are lipid‐based, such as hyperlipidemia and atherosclerosis (Rajadurai & Prince, 2005; Swapna et al., 2019). Numerous studies have reported that ISO induction in experimental animals alter lipid metabolism and induce a change in the integrity and permeability of heart tissues and finally result in myocardial damage and dysfunction (Hemalatha & Prince, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Several CVDs are lipid-based, such as hyperlipidemia and atherosclerosis (Rajadurai & Prince, 2005;Swapna et al, 2019). Numerous studies have reported that ISO induction in experimental animals alter lipid metabolism and induce a change in the integrity and permeability of heart tissues and finally result in myocardial damage and dysfunction (Hemalatha & Prince, 2015).…”

Section: Discussionmentioning

confidence: 99%

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Pavithra¹,

Uddandrao²,

Chandrasekaran³

et al. 2020

J. Food Biochem.

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Cardiovascular disease (CVD) is the most common cause of global mortality and morbidity (Huiyao, Jiayin, & Chaoxiang, 2019; Saranya & Padma, 2018), and it has been estimated to affect up to 23.3 million individuals by 2030 (Hui et al., 2017). CVD refers to blood vessel and heart disorders, including coronary artery disease (CAD), elevated blood pressure, stroke, congenital heart defects, and congestive heart failure. Elevated generation of reactive oxygen species (ROS) leads to severe oxidative stress on the myocardium, which predisposes an individual to CVD, including congestive heart failure, ischemic heart disease, and atherosclerosis (Wattanapitayakul & Bauer, 2001). Myocardial infarction (MI) is caused by a critical imbalance between the oxygen supply and the demand for the myocardium, which

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Effects of asiatic acid, an active constituent in Centella asiatica (L.): restorative perspectives of streptozotocin-nicotinamide induced changes on lipid profile and lipid metabolic enzymes in diabetic rats

Cited by 10 publications

References 27 publications

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

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