Effects of Asiasari radix on the morphology and viability of mesenchymal stem cells derived from the gingiva

Jeong, Seong Mok; Lee, Ji‐Eun; Jin, Seong-Ho; Ko, Youngkyung; Park, Jun‐Beom

doi:10.3892/mmr.2014.2607

Cited by 21 publications

(24 citation statements)

References 21 publications

(26 reference statements)

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“…A plant extract used by Indians to stimulate neurogenesis obtained from Dhanwantram kashaya significantly increased proliferation and reduced senescence of Wharton‐jelly MSC (Warrier et al , ), while Astragalus and Salvia extracts reduced apoptosis in bone marrow MSC via stimulating c‐IAP‐1/2 expression and restricting caspase‐3 activation (Jing et al , ). On the other hand, root extract of Asasiarum reduced MSC viability at high concentration which indicates on adverse effects depending on the extract dose (Jeong et al , ). Similarly, an ethanol extract of the Ligustrum lucidum decreased the proliferation of bone marrow MSC in a dose‐dependent manner and a cytotoxic effect at a concentration of ≥200 μg/mL (Li et al , ).…”

Section: Herbal Extractsmentioning

confidence: 99%

The effects of chosen plant extracts and compounds on mesenchymal stem cells—a bridge between molecular nutrition and regenerative medicine‐ concise review

Kornicka

Kocherova

Marycz

2017

Phytotherapy Research

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Mesenchymal stem cells (MSC) stand as a promising tool in regenerative medicine because of their high therapeutic potential in treatment of degenerative, metabolic and other types of diseases. The cellular therapies involving MSCs include their isolation mainly from the bone marrow, adipose tissue or umbilical cord and in vitro expansion for further autologous or allogeneic transplantation. Recent studies revealed, that bioactive compounds, naturally occurring in seaweeds, herbs, fruits and vegetables, possess the ability to modulate self-renewal and differentiation potential of adult stem cells, targeting a broad range of intracellular signal transduction pathways. Number of ongoing trials aim to find a herbal extract that may become less toxic and affordable natural therapeutic. Mesenchymal stem cells are treated with crude extracts or individual compounds to investigate its effects and mechanism on stem cells proliferation and differentiation. Deeply investigated, herbal extract which increases tissue regeneration and promotes stem cell growth may be successfully applied in the field of biomaterials. Promoting the endogenous stem cell multipotency and their differentiation potential may additionally support the regenerative processes after MSCs transplantation. The review focuses on the beneficial effects of chosen plant derived substances on MSCs proliferative activity and their osteogenic differentiation potential. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Herbal Extractsmentioning

confidence: 99%

The effects of chosen plant extracts and compounds on mesenchymal stem cells—a bridge between molecular nutrition and regenerative medicine‐ concise review

Kornicka

Kocherova

Marycz

2017

Phytotherapy Research

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“…In our previous study, human GMSCs were isolated from the connective tissue of gingiva [22]. Cells were cultured with alpha modified minimal essential medium (a-MEM, Gibco, Grand Island, NY) containing 15% fetal bovine serum (Gibco), 100 U/mL penicillin, 100 mg/mL streptomycin (SigmaeAldrich Co, St. Louis, MO), 200 mM L-Glutamine (SigmaeAldrich Co), and 10 mM ascorbic acid 2-phosphate (SigmaeAldrich Co) in culture dishes (Corning, Tewksbury, MA).…”

Section: Isolation Of Human Gmscsmentioning

confidence: 99%

The effects of tetracycline-loaded silk fibroin membrane on proliferation and osteogenic potential of mesenchymal stem cells

Jin

Kweon

Park

et al. 2014

Journal of Surgical Research

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“…Icariin, derived from Epimedium is shown to effectively alleviate nephrectomy induced chronic renal failure through increasing renal stem cells [7]. However, the traditional Chinese medicine formula, Pien Tze Huang inhibited the proliferation, and induced the apoptosis and differentiation of cancer stem cells via suppression of the Notch1 pathway [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of Bambusa tulda on osteogenic differentiation and mineralization of human stem cells

Lee¹,

Uddin²,

Lee³

et al. 2018

biomedicalresearch

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Bambusa tulda has been used for various Purpose and is considerd as one of the most useful bamboo species. This study aimed to evaluate the effects of Bambusa tulda extract (BBT) on the osteogenic differentiation and mineralization of human mesenchymal stem cells. Stem cells obtained from gingivae were cultured in an osteogenic medium in the presence of BBT at concentrations ranging from 0.001% to 1%. Evaluations of cell morphology and cellular viability were done at days 1, 3, 5 and 7. Alkaline phosphatase activity assays and Alizarin red S staining were performed to evaluate the osteogenic differentiation of stem cells. The morphology of stem cells in the presence of BBT at final concentrations of 0%, 0.001%, 0.01%, 0.1%, and 1% did not show any noticeable changes when compared with the untreated control group. The treatment of BBT (from 0.001% to 1% groups) showed decrease in alkaline phosphatase activity. The results of the Alizarin Red S staining showed a significant decrease with application of BBT. Conclusively, Bambusa tulda had influenced the osteogenic differentiation of the stem cells derived from the gingiva. Thus, the use of Bambusa tulda may produce adverse effects onto oral tissues. The concentration and application time of Bambusa tulda should be meticulously controlled to minimize the adverse effects.

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Effects of Asiasari radix on the morphology and viability of mesenchymal stem cells derived from the gingiva

Cited by 21 publications

References 21 publications

The effects of chosen plant extracts and compounds on mesenchymal stem cells—a bridge between molecular nutrition and regenerative medicine‐ concise review

The effects of chosen plant extracts and compounds on mesenchymal stem cells—a bridge between molecular nutrition and regenerative medicine‐ concise review

The effects of tetracycline-loaded silk fibroin membrane on proliferation and osteogenic potential of mesenchymal stem cells

Evaluation of the effects of Bambusa tulda on osteogenic differentiation and mineralization of human stem cells

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