Effects of Arctium lappa on Cadmium-Induced Damage to the Testis and Epididymis of Adult Wistar Rats

Predes, Fabricia de Souza; Diamante, Maria Aparecida Silva; Foglio, Mary Ann; Dolder, Heidi

doi:10.1007/s12011-016-0663-x

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…(2007) [35] observed that animals exposed to higher concentrations of Ni in a shorter time of exposure showed a reduction in DT and EH, in addition to an increase in the lumen diameter (LD). However, similar results to the present study were observed by Lima et al (2018) [25] in rats after exposure of As 5+ and As 3+ (0.01 and 10 mg/L for 56 days), by Oliveira (2010) [59] with Ni (0.67 and 1.34 g/L for 60 days) and by Li et al (2016) [37] and Predes et al (2016) [38] with Cd (0.2 mg/L for 24 hours and 1.2 mg/kg for 7 and 56 days, respectively).…”

Section: Discussionsupporting

confidence: 92%

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Lozi

Dias

Silva

et al. 2022

Preprint

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Heavy metals are found naturally in the environment in small concentrations and the increase in their concentration occurs due to anthropogenic activities. Human exposure to heavy metals can induce various testicular damage. This study aimed to evaluate the action of the arsenate (As + 5), arsenite (As + 3), cadmium (Cd), lead (Pb), chromium VI (Cr VI), and nickel (Ni) in the testicles of adult Swiss mice and establish an order of toxicity among these metals. Forty-two animals were randomly distributed into 7 experimental groups (n = 6). The control group received a saline solution and the other groups received 1.5 mg/kg of the heavy metal as follows: group 2 – As + 5, group 3 - As + 3, group 4 - Cd, group 5 - Pb, group 6 - Cr VI and group 7 - Ni. The administration was performed intraperitoneally in a single dose and the animals were euthanized seven days after exposure. Acute exposure to heavy metals induced functional, cellular, pathological, and oxidative stress alterations. The order of toxicity among the tested metals established by comparative damage analysis follows Ni > Cd > Cr VI = Pb > As + 3 > As + 5. In groups with higher toxicity, such as nickel and cadmium were observed functional changes, alterations in the testicular microstructure, and cell death. Based on our results, we can point out that the heavy metals tested can be harmful to male reproductive health in low doses and for a short period of exposure. Care must be greater taking into account the damage order defined in this work.

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Section: Discussionsupporting

confidence: 92%

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Lozi

Dias

Silva

et al. 2022

Preprint

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“…However, unlike the present study, the authors reported higher germinative epithelium loss, especially in animals that received 1.8 and 2.2 mg/kg of CdCl 2 , to increased testicular concentration of Ca and consequent dystrophic calcification. Predes et al [4, 58] also observed disorganized seminiferous tubules, besides reduced testicular weight of Wistar rats receiving a single dose of 1.2 mg/kg CdCl 2 i.p. and evaluated after 7 days.…”

Section: Discussionmentioning

confidence: 99%

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally

Mouro

Martins

Silva

et al. 2019

Oxidative Medicine and Cellular Longevity

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The toxic effects of cadmium (Cd) on reproductive parameters are widely described in the literature. Experimental models often make use of the intraperitoneal route (i.p.), although human intoxication occurs preferentially by the oral route and can be continuous. However, little is known about the effect of Cd administration routes on the testicular structure. Thus, this study investigated the testicular impact of Cd exposure comparing both i.p. and oral routes, both single dose (SD), in addition to the oral route in fractional doses (FD). Swiss adult male mice received CdCl2 1.5 mg/kg i.p., 30 mg/kg oral SD, and 4.28 mg/kg oral FD for 7 consecutive days. The Cd bioaccumulation was observed in all routes, mainly in the oral FD route. The concentrations of testicular Ca and Cu decreased in all animals exposed to Cd, while Zn and Mn decreased only in the i.p. route. Testicular SOD activity was reduced in both routes of oral administration, while CAT increased in the i.p. route, and GST increased in all animals exposed to Cd. Changes in the tubular parameters and cell viability were observed in both routes of Cd administration but were more intense in the oral route, mainly in the FD. Serum testosterone concentration was reduced in both routes of oral administration. Tubular damage, such as the vacuolization of the seminiferous epithelium, germ cell detachment, and seminiferous tubule degeneration, occurred in all groups exposed to Cd. Therefore, the oral Cd administration presented greater potential to promote testicular damage, mainly when the metal was given in a fractionated way.

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“…Arctium lappa L. (popularly known as burdock) is widely used in popular medicine worldwide as a diuretic and antipyretic agent and has also been used to treat hypertension, gout, hepatitis, and other inflammatory disorders [17,18]. Interest in A. lappa extracts has grown due to their ample therapeutic potential [19,20,21].…”

Section: Introductionmentioning

confidence: 99%

Arctium lappa Extract Suppresses Inflammation and Inhibits Melanoma Progression

et al. 2019

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Background: Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from A. lappa have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects of A. lappa hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. Methods: The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide. Results: Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival. Conclusions: Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression.

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Effects of Arctium lappa on Cadmium-Induced Damage to the Testis and Epididymis of Adult Wistar Rats

Cited by 10 publications

References 28 publications

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Comparative Toxicology of Heavy Metals Arsenate, Arsenite, Cadmium, Chrome Vi, Lead, and Nickel in the Testes of Adult Swiss Mice After Acute Exposure

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally

Arctium lappa Extract Suppresses Inflammation and Inhibits Melanoma Progression

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