Effects of aqueous humor hydrodynamics on human eye heat transfer under external heat sources

Tiang, Kor L.; Ooi, Ean Hin

doi:10.1016/j.medengphy.2016.05.011

Cited by 14 publications

(6 citation statements)

References 30 publications

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“…Equations (1), (5), (6) and 7along with the boundary conditions were first solved to obtain the steady-state temperature distribution and AH flow field in the AC, PC and TM of the eye. The simulated AH velocity was used as input into the drug transport equation (13) to solve for the drug concentration. Mesh convergence study was performed to ensure that the simulated results were independent of change in mesh densities (please see Supplementary material and Figures S1(a)-(e)).…”

Section: Methodsmentioning

confidence: 99%

“…The governing equation for the flow of heat ( Figure 1(a)) in both the AC and PC of the eye is described as 8,13 rcṽrT ð Þ= r Á krT…”

Section: Heat Transfermentioning

confidence: 99%

“…The second and third terms on the left-hand side represent the convective and diffusive transport of drug concentration, respectively. The assumptions used for solving equation (13) are provided in the Supplementary material. For the cornea and the AC part, equation (13) has been modified by including drug metabolic consumption…”

Section: ∂C ∂Tmentioning

confidence: 99%

“…Extensive numerical studies related to heat transfer, aqueous humor (AH) flow and drug transport in all the domains of an eye when applied topically are reported in the literature. [7][8][9][10][11][12][13][14][15] However, very few mathematical models have been developed for drug delivery from the therapeutic lens. To this end, Ferreira et al 16 developed a two-dimensional (2D) model to study drug transport from a therapeutic lens.…”

Section: Introductionmentioning

confidence: 99%

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Numerical modeling of therapeutic lens drug delivery in the anterior human eye for the treatment of primary open-angle glaucoma

Bhandari

Bansal

Sinha

2020

Proc Inst Mech Eng H

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A numerical model of drug delivery from a therapeutic lens in the anterior portion of the human eye has been developed for a more effective treatment plan of primary open-angle glaucoma. The numerical model takes into account the drug diffusion through the therapeutic lens along with heat transfer and aqueous humor flow in different orientations of the human eye (supine (two-dimensional) as well as standing (three-dimensional)). Results illustrate that the drug diffuses through the therapeutic lens to the cornea and is convected into the anterior chamber of the eye due to the temperature gradient across the eye. In addition, eye orientation significantly affects drug delivery with supine orientation providing better and uniform drug exposure in different target regions of the eye as compared to standing in the case of the therapeutic lens. Furthermore, a comparison of the therapeutic efficacy of the therapeutic lens has been done with topical administration and the drug uptake results from both the drug delivery modes have been validated with the experimental data reported in the literature. The developed model may help ophthalmologists to comprehend the transport and retention of different drugs in different domains and orientations of the human eye when administered through a therapeutic lens.

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Section: Methodsmentioning

confidence: 99%

“…The governing equation for the flow of heat ( Figure 1(a)) in both the AC and PC of the eye is described as 8,13 rcṽrT ð Þ= r Á krT…”

Section: Heat Transfermentioning

confidence: 99%

Section: ∂C ∂Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Numerical modeling of therapeutic lens drug delivery in the anterior human eye for the treatment of primary open-angle glaucoma

Bhandari

Bansal

Sinha

2020

Proc Inst Mech Eng H

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“…The human eye model is designed using the COMSOL Multiphysics simulation tool and the design is carried out referring to the journals [8][9][10][11][12][13][14][15][16][17][18] and based on the study authors have applied various boundary conditions and constraints on the model. Images are recorded by Corvis tonometer [19] enable to determine the biomechanical parameters of the eye.…”

Section: Introductionmentioning

confidence: 99%

Investigation of deformation of the cornea during tonometry using FEM

Bharathi¹,

Prabhu²,

Ramesh³

et al. 2020

IJECE

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A three dimensional finite element model of the human eye is developed to evaluate the force which will be applied over the surface of cornea during tonometry and gonioscopy tests. The standard tonometers and gonioscopy experiences deformation from 0.5mm to 3mm of the cornea is adopted during both point contact and boundary contact on the surface of the cornea. The results demonstrate the maximum force experienced by the tonometer with point contact at the center of the cornea for the maximum possible deformation of the cornea during tonometry. The study also analyzes for the force experienced by the tonometer or goniolens with boundary layer contact for the defined deformation of the cornea along the direction from cornea towards the retina.

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Ocular Fluid Mechanics and Drug Delivery: A Review of Mathematical and Computational Models

Bhandari

2021

Pharm Res

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Effects of aqueous humor hydrodynamics on human eye heat transfer under external heat sources

Cited by 14 publications

References 30 publications

Numerical modeling of therapeutic lens drug delivery in the anterior human eye for the treatment of primary open-angle glaucoma

Numerical modeling of therapeutic lens drug delivery in the anterior human eye for the treatment of primary open-angle glaucoma

Investigation of deformation of the cornea during tonometry using FEM

Ocular Fluid Mechanics and Drug Delivery: A Review of Mathematical and Computational Models

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