Effects of aqueous extracts of Hibiscus macranthus and Basella alba in mature rat testis function

Moundipa, F Paul; Kamtchouing, P.; Koueta, Noussithé; Tantchou, Justine; Foyang, N.P.R; Mbiapo, Félicité Tchouanguep

doi:10.1016/s0378-8741(98)00207-4

Cited by 49 publications

(37 citation statements)

References 7 publications

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“…The increased levels of the hormone have been involved in the ability of different medicinal plants to improve sexual function. [10][11][12] The effect shown by the acute administration of Ferula extract dosed at 30 mg/kg, mainly exerted on the appetitive component, may be ascribed to mechanisms other than testosterone.…”

Section: Discussionmentioning

confidence: 99%

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

et al. 2003

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Sexually potent and sluggish/impotent male rats were orally treated with an extract of Ferula hermonis (30 and 60 mg/kg). The acute administration stimulated sexual motivation in potent rats and improved copulatory performance in sluggish/impotent rats. This last effect was elicited only by the higher dose, which, in parallel, increased serum testosterone levels in rats. On the contrary, when the extract was subchronically administered (10 days) a marked reduction in the percentage of rats achieving ejaculation was detected, together with a general impairment of the copulatory pattern. Furthermore, the repeated administration of the extract (6 mg/kg/day for 10 days) resulted in a significant reduction of testosterone levels in comparison with controls. The present results discourage a repeated assumption of F. hermonis, while suggesting its acute administration to improve the performance in sexual dysfunctions.

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Section: Discussionmentioning

confidence: 99%

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

et al. 2003

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“…1), isolated from Hibiscus vitifolius L. flowers, showed significant anti-inflammatory activity at a dose of 200 mg/kg body weight against carrageenaninduced rat paw edema and increased vascular permeability induced by various phlogistic agents. It also inhibited significantly the accumulation of the pouch fluid and granulation tissue formation in carrageenan-induced granuloma pouch in rats, which could be attributed to decreased Aqueous extract of leaves (female antifertility) and virilizing effect) Telefo et al, 1998 Aqueous extract of leaves (anabolizing Moundipa et al, 1999 H. rosa-sinensis Benzene and alcohol extract of flowers (antifertility) Murthy et al, 1997;Kholkute et al, 1976Kholkute et al, , 1977Kholkute & Udupa, 1976a Raghunathan & Sulochana, 1994 formation of collagen tissue. Leukocyte migration and formation of pleural exudates were also reduced by gossypin (1) in carrageenan-and turpentine-induced pleurisy in rats; the efficiency was lower than phenylbutazone, but it possesses a greater margin of safety (Parmar & Ghosh, 1978).…”

Section: Anti-inflammatorymentioning

confidence: 91%

Biologically Active Compounds from the GenusHibiscus.

Vasudeva

Sharma

2008

Pharmaceutical Biology

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Since ancient times, Hibiscus species (Malvaceae) have been used as a folk remedy for the treatment of skin diseases, as an antifertility agent, antiseptic, and carminative. Some compounds isolated from the species, such as flavonoids, phenolic acids, and polysaccharides, are considered responsible for these activities. This review aims to summarize the worldwide reported biological activities and phytoconstituents associated with this genus for the past 40 years.

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“…By contrast, administration of Hibiscus macrocanthus (Malvaceae) and Basella alba (Basellaceae) extracts caused an increase in the serum levels of testosterone and in the weight of the rat testis [15] . However, despite of widespread use of U. pilulifera as folk medicine to control DM and other ailments, its impacts on the reproductive system has not been reported.…”

Section: Introductionmentioning

confidence: 92%

Effects of Leaf Extract of Urtica pilulifera L. on Male Reproductive System of Streptozotocin-Diabetic Rats

Irshaid¹,

Mm²

2009

American J. of Pharmacology and Toxicology

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Problem statement: Urtica pilulifera L. (Urticaceae), has long been used for the treatment of various aliments including diabetes. Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. Therefore, the current study was designed to investigate the effects of Urtica pilulifera on the reproductive system of diabetic rats. Approach: Forty male rats were evenly divided into four groups: Group I consisted of non-diabetic rats that received only the vehicle; group II-IV was injected intraperitonially with a single dose of streptozotocin (STZ) of 70 mg kg; groups III and IV were given methanol extract of Urtica pilulifera orally, 3 days after the STZ injection, at daily doses of 1.0 and 2.0 g kg −1 , respectively. After 4 weeks of treatments, all the rats were sacrificed. Results: Administration of 70 mg kg −1 of streptozotocin to male rats induced diabetes and significantly reduced the body and sex organ weights, testosterone levels, sperm count and motility and significantly increased the glucose levels and water and food intake. By contrast, rats given the Uritica pilulifera methanol extract had significantly improved body weight gain, whereas the glucose levels, water and food intake significantly improved in treated diabetic male rats. In addition, this extract improved the reproductive system of the diabetic male rats by significantly increasing the testis and epididymis weights, testosterone levels, sperm count and motility. Conclusion/Recommendations: We concluded that the adverse effects of STZ-diabetes on reproductive system of male rats can be reversed by treatment with Urtica pilulifera leaf extract; and this leaf extract exhibits antihyperglycemic and spermatogenic activities. Based on these findings, we suggested the possible utilization of Urtica pilulifera extracted as a therapy to prevent the development of diabetes in later life and improved the performance of male reproductive system in animals and humans.

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Effects of aqueous extracts of Hibiscus macranthus and Basella alba in mature rat testis function

Cited by 49 publications

References 7 publications

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

Biologically Active Compounds from the GenusHibiscus.

Effects of Leaf Extract of Urtica pilulifera L. on Male Reproductive System of Streptozotocin-Diabetic Rats

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