Effects of aquatic and land-based exercises on amyloid beta, heat shock protein 27, and pulse wave velocity in elderly women

Kim, Ji-Hyeon; Jung, Young-Suk; Kim, Jong-Won; Ha, Min‐Seong; Ha, Sol; Kim, Do-Yeon

doi:10.1016/j.exger.2018.03.024

Cited by 17 publications

(19 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a mouse model of AD, overexpression of Hsp27 improved the learning abilities, increased the excitability of synaptic neurons, and decreased the Aβ aggregates [33]. Additionally, it was also observed that the increase in Hsp27 expression after exercises prevented the aggregation of plaques and greatly improved brain function of elderly women [34].…”

Section: Alzheimer's Diseasementioning

confidence: 95%

See 1 more Smart Citation

Therapeutic potential of Hsp27 in neurological diseases

Venugopal

Sundaramoorthy

Vellingiri

2019

Egypt J Med Hum Genet

View full text Add to dashboard Cite

Background: Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and nonstress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps in neurodegenerative disorders is puzzling and not fully understood. This review aims to focus on the role of Hsp27 in normal and diseased conditions and emphasize its therapeutic potential. Hsp27: Hsp27, in particular, has shown to be involved in cell viability and actin cytoskeleton remodeling and also shown to improve many disease conditions. Phosphorylated Hsp27 modulates the p53 pathway by downregulating cellular senescence and also lowers reactive oxygen species to protect TNFα-mediated apoptosis. Hsp27 is also known to interfere with mitochondria-dependent and mitochondria-independent cell apoptotic stimulation.Conclusion: This article will highlight the various functions of Hsp27 especially as an anti-apoptotic factor and stress response factor and its therapeutic potential in preventing neuronal apoptosis in neurological diseases. This review also includes a comparison of the therapeutic potential of Hsp27 with regard to other small Hsps.

show abstract

Section: Alzheimer's Diseasementioning

confidence: 95%

“…Though being small in size, Hsp27 has a wide range of therapeutic potential. Limited studies were focused on its therapeutic abilities on AD, but there have been reports that have shown a restoration in the amyloid plaque and tangle formation [31][32][33][34].…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Therapeutic potential of Hsp27 in neurological diseases

Venugopal

Sundaramoorthy

Vellingiri

2019

Egypt J Med Hum Genet

View full text Add to dashboard Cite

show abstract

“…69 A 2018 study of 48 females (average age 66.9) randomized into three cohorts, a control group, an aquatic exercise group, and an intensity-matched land exercise group, found serum Aβ was significantly elevated in the aquatic cohort following a 16-week progressively intense aquatic exercise program monitoring heart rate, relative perceived exertion, increasing intensity every 4 weeks. 69 In the same study, investigators measured serum heat shock protein Hsp27, a protein effective against abnormal cytoplasmic protein damage and which plays a role in cellular cytoskeletal stabilization, and cellular homeostasis and protection. In both the aquatic and land exercise groups, Hsp27 showed statistically significant elevations: 11% in the aquatic group and 5% in the land group, indicating a positive cellular response to exercise.…”

Section: Aquatic Therapy Use In Dementiamentioning

confidence: 99%

“…In both the aquatic and land exercise groups, Hsp27 showed statistically significant elevations: 11% in the aquatic group and 5% in the land group, indicating a positive cellular response to exercise. 69 Several case studies have been published demonstrating remarkable gains in function, well beyond that achievable through current medications. 70,71 Although case studies fall into the lowest level of evidence, the surprising finding in these case reports was the immediacy of objective change in communication function, visual tracking, and motor performance, changes not seen in other physical environments.…”

Section: Aquatic Therapy Use In Dementiamentioning

confidence: 99%

Aquatic Therapy in Contemporary Neurorehabilitation: An Update

Becker

2020

PM&R

View full text Add to dashboard Cite

Aquatic therapy has been used extensively in a number of neurologic diseases and pathologies. This review describes disease-specific rehabilitative applications for this population. Recent research has offered scientific support for use in common neurological diseases that are part of rehabilitative practice, and very recent findings may create even firmer support for its use in these as well as other conditions. Stroke, Parkinsonism, and multiple sclerosis are areas that have recently received a significant number of published studies. Dementia is another area that has been more recently studied and received basic science support. Cerebral palsy has also had recent supportive evidence published. Available literature is reviewed to create a more evidence-based support for the use of aquatic therapy in neurorehabilitation.

show abstract

“…In a 6 month study, a resistance training exercise in women with probable MCI led to improved attention, memory, and brain plasticity (Nagamatsu et al, 2012). In a different study with both aquatic-and land-based exercise that was conducted for 16 weeks in elderly women, plasma Aβ and HSP27 levels were increased and vascular health was improved in these women (Kim et al, 2018). As cognitive training has also been shown to improve cognitive functioning, some studies have combined physical activity and cognitive exercises to enhance functional outcomes.…”

Section: Physical Activity and Cognitive Training Prevent Cognitive Dmentioning

confidence: 99%

Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity

Koller

Chakrabarty

2020

Front. Mol. Neurosci.

View full text Add to dashboard Cite

The inability of individual neurons to compensate for aging-related damage leads to a gradual loss of functional plasticity in the brain accompanied by progressive impairment in learning and memory. Whereas this loss in neuroplasticity is gradual during normal aging, in neurodegenerative diseases such as Alzheimer's disease (AD), this loss is accelerated dramatically, leading to the incapacitation of patients within a decade of onset of cognitive symptoms. The mechanisms that underlie this accelerated loss of neuroplasticity in AD are still not completely understood. While the progressively increasing proteinopathy burden, such as amyloid β (Aβ) plaques and tau tangles, definitely contribute directly to a neuron's functional demise, the role of non-neuronal cells in controlling neuroplasticity is slowly being recognized as another major factor. These non-neuronal cells include astrocytes, microglia, and oligodendrocytes, which through regulating brain homeostasis, structural stability, and trophic support, play a key role in maintaining normal functioning and resilience of the neuronal network. It is believed that chronic signaling from these cells affects the homeostatic network of neuronal and non-neuronal cells to an extent to destabilize this harmonious milieu in neurodegenerative diseases like AD. Here, we will examine the experimental evidence regarding the direct and indirect pathways through which astrocytes and microglia can alter brain plasticity in AD, specifically as they relate to the development and progression of tauopathy. In this review article, we describe the concepts of neuroplasticity and glial plasticity in healthy aging, delineate possible mechanisms underlying tau-induced plasticity dysfunction, and discuss current clinical trials as well as future disease-modifying approaches.

show abstract

Effects of aquatic and land-based exercises on amyloid beta, heat shock protein 27, and pulse wave velocity in elderly women

Cited by 17 publications

References 50 publications

Therapeutic potential of Hsp27 in neurological diseases

Therapeutic potential of Hsp27 in neurological diseases

Aquatic Therapy in Contemporary Neurorehabilitation: An Update

Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity

Contact Info

Product

Resources

About