Therapeutic potential of Hsp27 in neurological diseases

Abstract

Background: Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and nonstress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps in neurodegenerative disorders is puzzling and not fully understood. This review aims to focus on the role of Hsp27 in normal and diseased conditions and emphasize its therapeutic potential. Hsp27: Hsp27, in particular, has shown to be involved in cell viability and actin cytoskeleton remodeling and also shown to improve many disease conditions. Phosphorylated Hsp27 modulates the p53 pathway by downregulating cellular senescence and also lowers reactive oxygen species to protect TNFα-mediated apoptosis. Hsp27 is also known to interfere with mitochondria-dependent and mitochondria-independent cell apoptotic stimulation.Conclusion: This article will highlight the various functions of Hsp27 especially as an anti-apoptotic factor and stress response factor and its therapeutic potential in preventing neuronal apoptosis in neurological diseases. This review also includes a comparison of the therapeutic potential of Hsp27 with regard to other small Hsps.

Mitochondria-containing Extracellular Vesicles (EV) Reduce Mouse Brain Infarct Sizes and EV/HSP27 Protect Ischemic Brain Endothelial Cultures

“…14a ). Notably, sEV/HSP27, m/lEV/HSP27, and EV/HSP27 mixtures significantly increased cell viability compared to untreated cells and are likely an additive effect of naïve EV mitochondrial transfer and anti-apoptotic/cell proliferation effects of HSP27 (115–118).…”

Photothermal and Photodynamic Therapies via NIR-Activated Nanoagents in Combating Alzheimer’s Disease

“…Moreover, Hsp27 also serves as an antioxidant that lowers the ROS and iron levels by raising intracellular glutathione levels. 59 Overall, PTT has shown particular promise as a potential AD therapy.…”

“…Phosphorylated Hsp27 can protect the cytoskeleton and provide resistance to apoptotic stimuli under stressed conditions. Moreover, Hsp27 also serves as an antioxidant that lowers the ROS and iron levels by raising intracellular glutathione levels . Overall, PTT has shown particular promise as a potential AD therapy.…”

Nimesulide derivatives reduced cell proliferation against breast and ovarian cancer: synthesis, characterization, biological assessment, and crystal structure.

“…HSP27 expression is affected by stress conditions such as chemotherapy drugs (Ferms et al, 2006;Jego et al, 2013;Jaragh-Alhadad, 2018;Venugopal et al, 2019). Over-expression of HSP27 in cancer cells causes anti-apoptotic mechanism (Arya et al, 2007;Garrido et al, 2006;Paul et al, 2010) and cancer cell survival to lethal levels (Lianos et al, 2015;Vidyasagar et al, 2012) and metastasis (Pavan et al, 2013;Zhao et al, 2012).…”