Effects of apomorphine on self-stimulation

St-Laurent, Jacques; Leclerc, Robert; Mitchell, Mary L.; Miliaressis, Theris E.

doi:10.1016/0091-3057(73)90083-x

Cited by 25 publications

(1 citation statement)

References 23 publications

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“…The indirect agonists, preserving and accentuating the temporal patterning of dopamine release, enhance the acquisition of conditioned behaviour (Rensch & Rahmann, 1960;Kelemen & Bovet, 1961;Bannerjee, 1971) and also enhance intracranial self-stimulation (Crow, 1972;Cooper et al 1974). On the other hand, the direct-acting agonists have equivocal effects on both of these two forms of behaviour (Wauquier & Niemegeers, 1973;St Laurent et al 1973;Da vies et al 1974;Broekkamp & Van Rossum, 1974;Mora et al 1976). The resolution of the paradoxical ineffectiveness of direct-acting dopamine agonists in producing psychotic changes in man follows similar lines: it is proposed that the role of dopamine in the psychosis-related learning process involves temporally-patterned dopamine release, which is accentuated by amphetamine-like drugs, but merely' blurred' by the direct-acting agents.…”

Section: (Iii) Direct Dopamine Agonists Are Not Powerfully Psychotogenicmentioning

confidence: 99%

Major psychosis and dopamine: controversial features and some suggestions

Miller

1984

Psychol. Med.

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SynopsisThree problems with the dopamine hypothesis of major psychosis are pointed out: the long time-course of neuroleptic therapy; the absence of tolerance to the antipsychotic effects of neuroleptic drugs, or of a supersensitivity psychosis on drug withdrawal; and the absence of potent psychotogenic properties in the direct dopamine agonists. A resolution of these paradoxes is suggested relying on a role for dopamine in learning processes at a relatively high (cognitive) functional level. The hypothesis proposed is also used to explain the origin of some of the more distinctive psychotic symptoms.

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