Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and Type 2 diabetes

Neri, Sergio; Calvagno, S.; Mauceri, B.; Misseri, M.; Tsami, A.; Vecchio, C; Mastrosimone, Gianluca; Pino, Antonino Di; Maiorca, D.; Judica, A.; Romano, Giovanni Luca; Rizzotto, Agostino; Signorelli, Salvatore Santo

doi:10.1007/s00394-010-0099-6

Cited by 57 publications

(44 citation statements)

References 38 publications

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“…Matsuo (2005) demonstrated that the use of this grain can also be beneficial for increasing the production of liver antioxidant enzymes. The increase of these enzymes is related with the reduction of harmful effects caused by free radicals on the human body, which it leads to a reduced endothelial alterations (endothelial dysfunction) and decreased oxidation of LDL-c molecules, and hence, reduces the risks for vascular diseases (ADLER et al, 2010;NERI et al, 2010;KUSIRISIN et al, 2009;GHIBU et al, 2008;JI et al, 2008). The present study also demonstrated that this pseudocereal positively influenced the various risk factors for the development of diabetes and vascular diseases, which are the most frequent diseases today.…”

Section: Discussionmentioning

confidence: 99%

Use of cereal bars with quinoa (Chenopodium quinoa W.) to reduce risk factors related to cardiovascular diseases

et al. 2012

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Quinoa is considered a pseudocereal with proteins of high biological value, carbohydrates of low glycemic index, phytosteroids, and omega-3 and 6 fatty acids that bring benefits to the human health. The purpose of this study was to investigate the effects of quinoa on the biochemical and anthropometric profile and blood pressure in humans, parameters for measuring risk of cardiovascular diseases. Twenty-two 18 to 45-year-old students were treated daily for 30 days with quinoa in the form of a cereal bar. Blood samples were collected before and after 30 days of treatment to determine glycemic and biochemical profile of the group. The results indicated that quinoa had beneficial effects on part of the population studied since the levels of total cholesterol, triglycerides, and LDL-c showed reduction. It can be concluded that the use of quinoa in diet can be considered beneficial in the prevention and treatment of risk factors related to cardiovascular diseases that are among the leading causes of death in today's globalized world. However, further studies are needed to prove the benefits observed.

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Section: Discussionmentioning

confidence: 99%

Use of cereal bars with quinoa (Chenopodium quinoa W.) to reduce risk factors related to cardiovascular diseases

et al. 2012

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“…Endothelial dysfunction constitutes a critical derangement in the pathogenesis of diabetic vascular disease (6,20,53). Current evidence indicates that enhanced vascular oxidative stress plays an important role in endothelial dysfunction (25,36). Endothelial activation is a hallmark of endothelial dysfunction and is characterized by enhanced proinflammatory cytokine and chemokine release as well as increased cellular adhesion molecule expression.…”

Section: Discussionmentioning

confidence: 99%

Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells

Williams

Sutliff

et al. 2012

American Journal of Physiology-Cell Physiology

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Williams CR, Lu X, Sutliff RL, Hart CM. Rosiglitazone attenuates NF-B-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells. Am J Physiol Cell Physiol 303: C213-C223, 2012. First published May 9, 2012; doi:10.1152/ajpcell.00227.2011.-Vascular complications, a major cause of morbidity and mortality in diabetic patients, are related to hyperglycemia-induced oxidative stress. Previously, we reported that rosiglitazone (RSG) attenuated vascular expression and activity of NADPH oxidases in diabetic mice. The mechanisms underlying these effects remain to be elucidated. We hypothesized that RSG acts directly on endothelial cells to modulate vascular responses in diabetes. To test this hypothesis, human aortic endothelial cells (HAECs) were exposed to normal glucose (NG; 5.6 mmol/l) or high glucose (HG; 30 mmol/l) concentrations. Select HAEC monolayers were treated with RSG, caffeic acid phenethyl ester (CAPE), diphenyleneiodonium (DPI), small interfering (si)RNA (to NF-B/p65 or Nox4), or Tempol. HG increased the expression and activity of the NADPH oxidase catalytic subunit Nox4 but not Nox1 or Nox2. RSG attenuated HG-induced NF-B/p65 phosphorylation, nuclear translocation, and binding to the Nox4 promoter. Inhibiting NF-B with CAPE or siNF-B/p65 also reduced HG-induced Nox4 expression and activity. HG-induced H 2O2 production was attenuated by siRNA-mediated knockdown of Nox4, and HG-induced HAEC monocyte adhesion was attenuated by treatment with RSG, DPI, CAPE, or Tempol. These results indicate that HG exposure stimulates HAEC NF-B activation, Nox4 expression, and H 2O2 production and that RSG attenuates HG-induced oxidative stress and subsequent monocyte-endothelial interactions by attenuating NF-B/p65 activation and Nox4 expression. This study provides novel insights into mechanisms by which the thiazolidinedione peroxisome proliferatoractivated receptor-␥ ligand RSG favorably modulates endothelial responses in the diabetic vasculature.peroxisome proliferator-activated receptor-␥; nuclear factor-B; hyperglycemia; reduced nicotinamide adenine dinucleotide phosphatase oxidase; reactive oxygen species DIABETES MELLITUS IS CURRENTLY estimated to affect 285 million individuals worldwide (50). Cardiovascular disease is the leading cause of morbidity and mortality in diabetic patients (2,24). This diabetic complication is partially caused by the detrimental effects of hyperglycemia (9), a critical mediator in the development and progression of atherosclerosis (3). Hyperglycemia-induced oxidative stress stimulates endothelial dysfunction, which is associated with endothelial activation and the upregulation of cellular adhesion molecules, cytokines, and chemokines (15,22,49). Collectively, these endothelial alterations promote monocyte binding to vascular endothelium and eventual monocyte migration into the subendothelial space, key initiating events in the development of atherosclerosis.The mitochondrial electron transport chain, xanthine oxidase, uncoupled endothelial nitric oxide synthase, and NADPH oxi...

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“…Therefore, development of targeted therapeutics is needed in order to ameliorate or eliminate diabetes associated kidney damage. In both experimental and clinical models of diabetes, antioxidants have been reported to reduce markers of oxidative stress [12,13]. Besides, some studies have showed that antioxidants are effective and cheaper than conventional therapy in management of some diseases [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Daniel¹

2015

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Abstract:The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.

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Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and Type 2 diabetes

Cited by 57 publications

References 38 publications

Use of cereal bars with quinoa (Chenopodium quinoa W.) to reduce risk factors related to cardiovascular diseases

Use of cereal bars with quinoa (Chenopodium quinoa W.) to reduce risk factors related to cardiovascular diseases

Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells

Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

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