Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Daniel, Eze Ejike

doi:10.11648/j.cb.20150301.11

Cited by 7 publications

(7 citation statements)

References 43 publications

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“…In our investigation, it was observed that rats administered with lycopene, CoQ10 and their combination showed reduction in elevated blood glucose level. These findings are harmonious with the previous literatures (Mahajan et al, 2020;Pansare et al, 2021).…”

Section: Discussionsupporting

confidence: 93%

“…STZ administered rats showed elevated level of blood glucose than control group. Raised in blood glucose was reported in DM induced by STZ to study diabetes and its complications (Pansare et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…in 0.1M buffer (citrate pH 4.5) and consider as DN rats, Group lll: DN rats receiving lycopene (5mg/kg/p.o./day) for 4 weeks, Group lV: DN rats received CoQ10 (10 mg/kg/p.o./day) from week 1 to 4, Group V: DN rats administered with lycopene (5mg/kg/p.o./day) and CoQ10 (10mg/kg/p.o./day) daily for 4 weeks. Dose of STZ (Mahajan et al, 2020), Lycopene (Pansare et al, 2021) and CoQ10 (Mahajan et al, 2020) was selected as given in the literature. All the group were assessed after every week and at the end of 4 th week for behavioral parameters.…”

Section: Experimental Protocolmentioning

confidence: 99%

“…Reports suggested that lycopene interact with vitamin C, E, β-carotene and lutein, thereby increases its free radicals scavenging activity in the lipoprotein particle (Leh, 2022;Pansare et al, 2021;Upaganlawar et al, 2010), no study have been reported the effects of combination of lycopene and CoQ10 in neuropathic pain. Based on the available findings, this reaserch was outlined to described the effect of lycopene and CoQ10 alone or in consolidation in peripheral diabetic neuropathy in animals.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Lycopene alone and along with Coenzyme-Q10 in Streptozotocin Induced Peripheral Neuropathy: Biochemical & Behavioural Study

Kasar¹,

Rasal²,

Mahajan³

et al. 2023

NRFHH

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Diabetic Neuropathy (DN) is major chronic consequences of the diabetes. DN is developed due to chronic hyperglycemia which is related with generation of oxidative stress (OS) and alteration in the neuronal function. This study was envisaged to find the desirable neuroprotective outcomes of natural antioxidants i.e., lycopene and coenzyme Q10 (CoQ10) as monotherapy or concomitant administration in rats subjected to DN induced by streptozotocin (STZ). Single subcutaneous dose of STZ (55 mg/kg) was used to induce DN in male wistar rats (200–250 g). Significant neuropathy was observed after four weeks of streptozotocin injection. Neuropathy was evaluated by behavioral parameters using mechanical allodynia, mechanical hyperalgesia, heat/thermal hyperalgesia and walking track analysis. Oxidative stress was determined by assessment of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and nitric oxide (NO) in homogenate of sciatic nerve. STZ significantly alters all the behavioral as well as biochemical parameters. Treatment with lycopene (5mg/kg/p.o.), CoQ10 (10mg/kg, p.o.) and their combination for four weeks significantly reduced blood glucose level. The behavioural and biochemical alteration was significantly improved with the combination of lycopene and CoQ10. The combination of both the antioxidants significantly reversed the streptozotocin induced neuropathy in rats compared to alone antioxidants as well as diabetic neuropathy group. It is concluded that neuroprotective effect of lycopene, CoQ10 alone and in combination might be due to their strong antioxidant property.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Lycopene alone and along with Coenzyme-Q10 in Streptozotocin Induced Peripheral Neuropathy: Biochemical & Behavioural Study

Kasar¹,

Rasal²,

Mahajan³

et al. 2023

NRFHH

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show abstract

“…Furthermore, the kidney slices obtained from the diabetic animals and stained with the hematoxylin and eosin showed glomerular expansion and tubular alveolar degeneration. A previous work [99] mentioned that the induction with streptozotocin caused damage to the kidney tissue of diabetic rats, and the untreated group showed severe glomerular necrosis with lymphocyte hyperplasia when compared with the normal. This result is similar to the work carried out by Trujillo et al [100], who reported that abnormal levels of serum urea usually signify decreased renal function, so plasma urea is a recognized marker of glomerular filtration rate (GFR) and in nephropathy.…”

Section: Discussionmentioning

confidence: 95%

Fortification of Fermented Camel Milk with Salvia officinalis L. or Mentha piperita Leaves Powder and Its Biological Effects on Diabetic Rats

Shahein,

El-Sayed,

Raya-Álvarez

et al. 2023

Molecules

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The incorporation of fermented camel milk with natural additives possesses numerous benefits for the treatment of various pathological and metabolic conditions. The present study investigated the impact of fortification of fermented camel milk with sage or mint leaves powder (1 and 1.5%, respectively) on glucose and insulin levels, lipid profile, and liver and kidney functions in alloxan-induced diabetic rats. The gross chemical composition of sage and peppermint leaves powder was studied. The chemical composition of sage and mint extracts was performed using liquid chromatography–electrospray ionization–tandem mass spectrometry (LC-MS) of sage and mint extracts. Furthermore, a total of forty-two adult normal male albino rats were included in this study, whereas one group was kept as the healthy control group (n = 6 rats) and diabetes was induced in the remaining animals (n = 36 rats) using alloxan injection (150 mg/kg of body weight). Among diabetic rats groups, a control group (n = 6 rats) was kept as the diabetic control group whereas the other 5 groups (6 rats per group) of diabetic rats were fed fermented camel milk (FCM) or fermented camel milk fortified with 1 and 1.5% of sage or mint leaves powder. Interestingly, the oral administration of fermented camel milk fortified with sage or mint leaves powder, at both concentrations, caused a significant decrease in blood glucose level and lipid profile, and an increase in insulin level compared to the diabetic control and FCM groups. Among others, the best results were observed in the group of animals that received fermented camel milk fortified with 1.5% sage powder. In addition, the results revealed that the fermented camel milk fortified with sage or mint leaves powder improved the liver and kidney functions of diabetic rats. Our study concluded that the use of sage and mint leaves powder (at a ratio of 1.5%) with fermented camel milk produces functional food products with anti-diabetic activity.

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Efficacy of lycopene on modulation of renal antioxidant enzymes, ACE and ACE gene expression in hyperlipidaemic rats

Khan

Noori

Mahboob

2016

J Renin Angiotensin Aldosterone Syst

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Introduction:We aimed to evaluate the efficacy of lycopene on renal tissue antioxidant enzymes and angiotensin converting enzyme (ACE) gene expression and serum activity in diet-induced hyperlipidaemia.Methods:Thirty-two female Wistar albino rats (200–250 g weight), 5–6 months of age, were randomly selected and divided into four groups. Group I received normal diet; group II received 24 g high fat diet/100 g of daily diet; group III received 24 g high fat diet/100 g daily diet and 200 ml of lycopene extract (twice a week) for 8 weeks; and group IV received 200 ml oral lycopene extract twice a week for 8 weeks.Results:A marked increase was observed in plasma urea and creatinine levels, serum C-reactive protein, kidney weight, tissue renal malonyldialdehyde level, ACE gene expression and serum level, while a decrease catalase level among hyperlipidaemic rats was observed. Histologically, interstitial inflammation and proliferation was seen. Lycopene supplementation significantly decreased plasma urea and creatinine, serum ACE, renal tissue malonyldialdehyde level and C-reactive protein level, while it increased tissue antioxidant enzymes level and total protein. Tissue inflammation and proliferation was improved.Conclusions:This finding suggests that supplementation of lycopene is effective for renal antioxidant enzymes, ACE gene expression and ACE serum level in hyperlipidaemic rats.

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Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Cited by 7 publications

References 43 publications

Effect of Lycopene alone and along with Coenzyme-Q10 in Streptozotocin Induced Peripheral Neuropathy: Biochemical & Behavioural Study

Effect of Lycopene alone and along with Coenzyme-Q10 in Streptozotocin Induced Peripheral Neuropathy: Biochemical & Behavioural Study

Fortification of Fermented Camel Milk with Salvia officinalis L. or Mentha piperita Leaves Powder and Its Biological Effects on Diabetic Rats

Efficacy of lycopene on modulation of renal antioxidant enzymes, ACE and ACE gene expression in hyperlipidaemic rats

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