Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: A single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls

Neri, Sergio; Signorelli, Salvatore Santo; Torrisi, Benedetto; Pulvirenti, Davide; Mauceri, B.; Abate, Giuseppe; Ignaccolo, L.; Bordonaro, F; Cilio, Danila; Calvagno, S.; Leotta, C

doi:10.1016/j.clinthera.2005.11.006

Cited by 94 publications

(59 citation statements)

References 44 publications

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“…For example, Duffy et al (1999) showed in a randomized double blind trial that ascorbic acid supplementation can lower the blood pressure in otherwise healthy hypertensive patients. Another positive clinical study used a combination of antioxidants (NAC, Vitamin E (VitE) and Vitamin C (VitC)) to treat young (mean age 41) diabetic patients or patients with impaired glucose tolerance (IGT), and found a reduction of oxidative stress and inflammation after 15 days of treatment (Neri et al 2005). The combination of VitE, fish oil, niacin and γ-oryzanol showed a beneficial effect in reducing oxidative stress and inflammatory markers in young dyslipidemic patients (Accinni et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Basic Mechanisms of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Injury

Papaharalambus

Griendling

2007

Trends in Cardiovascular Medicine

290

224

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The development of vascular disease has its origins in an initial insult to the vessel wall by biological or mechanical factors. The disruption of homeostatic mechanisms leads to alteration of the original architecture of the vessel and its biological responsiveness, contributing to acute or chronic diseases such as stroke, hypertension and atherosclerosis. Endothelial dysfunction, macrophage infiltration of the vessel wall, and proliferation and migration of smooth muscle cells all involve different types of reactive oxygen species, produced by various vessel wall components. Although basic science and animal research have clearly established the role of reactive oxygen species in the progression of vascular disease, the failure of clinical trials with antioxidant compounds has underscored the need for better antioxidant therapies and a more thorough understanding of the role of reactive oxygen species in cardiovascular physiology and pathology.The fundamental processes underlying the development of vascular diseases such as atherosclerosis, restenosis and hypertensive vascular remodeling have their origins in an initial insult to the vessel wall. Such an insult may arise from mechanical disruption that occurs during percutaneous coronary angioplasty or at regions of oscillatory shear stress, or it can result from biological causes, such as hypercholesterolemia, excess free radicals, diabetes, increased concentrations of plasma homocysteine, or infectious agents. Injury promotes disruption of the homeostatic mechanisms of the endothelial protective barrier, changing its natural properties, increasing its adhesiveness to leukocytes and altering its permeability. This endothelial dysfunction also leads to the formation of vasoactive molecules, which in turn induce inflammatory genes, inactivate nitric oxide (NO • ) and its protective functions, and activate matrix metalloproteinases, leading to extracellular matrix remodeling, and increased smooth muscle cell (VSMC) growth, migration and proliferation. Each of these processes contributes to thickening of the vessel wall or the formation of lesions that can lead to hypertension, acute myocardial infarction and stroke. Reactive Oxygen Species and Vascular InjuryIn the past decade a staggering amount of evidence implicates a common denominator, reactive oxygen species (ROS), in the development of most cardiovascular diseases (Figure 1). Superoxide (O 2 •− ) and hydrogen peroxide (H 2 O 2 ) are two of the most biologically important ROS in the cardiovascular system, and are produced in vascular cells by a number of oxidases, including the NADPH oxidases (Nox) and xanthine oxidase, lipoxygenases, cytochrome p450,

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Section: Discussionmentioning

confidence: 99%

Basic Mechanisms of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Injury

Papaharalambus

Griendling

2007

Trends in Cardiovascular Medicine

290

224

View full text Add to dashboard Cite

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“…Vários estudos na literatura descrevem o uso de suplementos antioxidantes no tratamento de diversas patologias: alguns deles, com atividade direta sobre espécies reativas, e outros como quelantes de metais indutores de estresse oxidativo, como o Succimer ® (2,3-dimercaptosuccinatos) e orto-difenóis. 9,30,[132][133][134] Quanto ao uso de vitaminas antioxidantes, há um vasto e controverso campo de descobertas. As vitaminas C, E e o b-caroteno têm sido apontados como atuantes na prevenção de doenças crônicas, em especial doenças cardiovasculares (DCV) e câncer.…”

Section: Antioxidantes Na áRea Nutricionalunclassified

Fontes vegetais naturais de antioxidantes

et al. 2009

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“…Conclusion. Nous avons montré que, à moyen terme, les protéines de colza prévenaient la détérioration de l'insulino-sensibilité induite par un régime gras et sucré chez le rat, avec une efficacité similaire à celle d'un régime riche en AGPI n-3 et pauvre en saccharose (Mariotti et al, 2008a (Blendea et al, 2005 ;Ceriello, 2004 ;Ceriello et al, 2002 ;Daskalova et al, 2005 ;Neri et al, 2005 ;Title et al, 2000 ;Vogel et al, 1997). En particulier, la dysfonction endothéliale vasculaire est l'objet d'un intérêt particulier : elle décrit de façon intégrative l'altération de l'homéostasie vasculaire, au niveau du tissuclé qu'est l'endothélium vasculaire ; elle signe l'initiation d'un phénotype pro-athérogène au niveau vasculaire ; elle est étroitement liée au risque cardiovasculaire et diabétique (Brunner et al, 2005 ;Davignon et Ganz, 2004).…”

Section: Intérêt Spécifique Des Protéines De Colza -Valeur Nutritionnunclassified

Évaluation de l’intérêt nutritionnel d’isolats de protéines de colza chez le rat et l’Homme : application à la prévention du syndrome métabolique

Hermier

Huneau

Tomé

et al. 2010

OCL

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Plant protein have long been opposed to animal protein because some plant protein present a relative mismatch between their amino acid pattern and human requirements for the renewal of body protein. Nevertheless, beyond its theoretical relevance to match the metabolic demand for protein metabolism, the amino acid pattern of dietary protein may also be of importance in the nutritional prevention of certain metabolic diseases. Of major public health concern is the metabolic syndrome, a cluster of risk factors associating obesity, insulin resistance, endothelial dysfunction, and low-grade inflammation. Two amino acids may be of importance in the pathophysiology of the metabolic syndrome: cysteine, the glutathione precursor, and arginine, the nitric oxide precursor. In this context, rapeseed protein, which is rich in cysteine and a good source of arginine, is an attractive candidate for studying the potential of dietary protein to prevent insulin resistance and related metabolic/ physiological abnormalities in the setting of the metabolic syndrome. After having presented a study demonstrating the high postprandial nitrogen utilization of rapeseed protein in humans, this review report two studies from our group showing that 1) rapeseed protein prevents the onset of insulin resistance induced by a diet rich in saturated fatty acids and sucrose in rats ; 2) rapeseed protein alleviates the postprandial vascular endothelial dysfunction and oxidative stress coming after a meal rich in saturated fatty acids and sucrose. The beneficial preventive effects can be accounted for, at least to some extent, by the high cysteine and arginine content of the rapeseed protein. Studies are urgently needed to assess the beneficial effect of this emerging protein source in humans.

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Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: A single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls

Cited by 94 publications

References 44 publications

Basic Mechanisms of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Injury

Basic Mechanisms of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Injury

Fontes vegetais naturais de antioxidantes

Évaluation de l’intérêt nutritionnel d’isolats de protéines de colza chez le rat et l’Homme : application à la prévention du syndrome métabolique

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