2005
DOI: 10.1016/j.pnpbp.2005.01.009
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Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression

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Cited by 72 publications
(63 citation statements)
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References 30 publications
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“…It may be that leptin deficiency occurs in a subgroup of depressed patients. A very recent study reported that improvement from depression with antidepressant treatment is associated with an elevation of plasma leptin levels (34). The antidepressant-like activity of leptin identified by the present study in animal models suggests that leptin might be effective in the treatment of depression, particularly for those patients with low leptin levels.…”
Section: Discussionsupporting
confidence: 59%
“…It may be that leptin deficiency occurs in a subgroup of depressed patients. A very recent study reported that improvement from depression with antidepressant treatment is associated with an elevation of plasma leptin levels (34). The antidepressant-like activity of leptin identified by the present study in animal models suggests that leptin might be effective in the treatment of depression, particularly for those patients with low leptin levels.…”
Section: Discussionsupporting
confidence: 59%
“…A follow-up study showed that bone loss over 24 months was significantly greater in depressed subjects than in controls. It was clinically indicated that bone mass was generally lower in depressed men compared to non-depressed men, and bone loss in depressed men was greater than in depressed women [38,39]. A large cross-sectional study of 2,000 men aged 65 to 92 years was conducted concerning the relationship between depression and BMD in men [35].…”
Section: Relationship Between Chronic Psychological Stress and Osteopmentioning
confidence: 99%
“…On the contrary, other studies showed that patients with different types or symptoms of depression, such as atypical depressive disorders, depressed mood and sleep disturbances as well as social isolation, had higher leptin levels than a control group [47,5456] . Researchers who investigated the effects of leptin on antidepressant treatments found out that leptin was increased during drug treatment [42,57] . As far as anxiety is concerned, Lawson et al [45] found that increased symptoms of anxiety were related with low levels of leptin, independent of BMI and weight, supporting that leptin is an antistress hormone (Table 1).…”
Section: Leptin's Role In Mood Regulationmentioning
confidence: 99%