Effects of anticonvulsants on hippocampus-generating seizures

Anticonvulsant Effects of Magnesium Sulfate in Hippocampal-Kindled Rats

“…In the studies cited above, the routes of administration included intracranial [28], i.p. [1,25] and oral [9], However, the following studies have demonstrated anticonvulsant effects following i.p. admin istration of phenytoin: 20 mg/kg phenytoin inhibited tonic seizures in the spontaneously epileptic rat [26]; phe nytoin increased the seizure threshold in amygdala-kind led rats [25]; and phenytoin reduced maximal electro shock seizures and comeal-kindled seizures in rats at nontoxic doses [27], A recent study demonstrated that phenytoin (10-100 mg/kg i.p.)…”

“…Phenytoin had no effect on pilocarpininduced seizures [28] or quinine-induced seizures [1] and was only weakly active against amygdala-kindled seizures [25]. In addition, phenytoin produced a proconvulsant action in hippocampal-kindled rats [9], The route of administration of phenytoin has been questioned [18], It…”