Anti- and proconvulsive actions of levcromakalim, an opener of ATP-sensitive K+ channel, in the model of hippocampus-generating partial seizures in rats

Katsumori, Hiroshi; Ito, Yuji; Higashida, Haruhiro; Hashii, Minako; Minabe, Yoshio

doi:10.1016/0014-2999(96)00400-1

Cited by 15 publications

(3 citation statements)

References 28 publications

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“…53 Pharmacological studies have demonstrated that K ATP channels play an important role in the control of seizure threshold in several in vitro and in vivo models. 3,[7][8][9][10][11][12]54 Moreover, it has been shown that mice lacking a subunit of K ATP channels (Kir 6.2 À/À mice) are vulnerable to hypoxia, exhibiting a reduced threshold for generalized seizure. 9 Transgenic mice, overexpressing the SUR1 gene in the forebrain, show a significant increase in the threshold for kainate-induced seizures.…”

Section: Discussionmentioning

confidence: 99%

ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice

Ghasemi

Shafaroodi

Karimollah

et al. 2010

Seizure

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Although there is evidence that diabetes affects seizure susceptibility, the underlying mechanism has not been completely understood. Several studies also suggest a pivotal role for K(ATP) channels in the seizure modulation. The aim of the present study was to evaluate the seizure threshold induced by pentylenetetrazole in diabetic mice at different times (3 days, 1-8 weeks) after induction of diabetes with streptozocin and to examine the possible role of ATP-sensitive potassium (K(ATP)) channels in this manner. Our data showed a time-dependent alteration in the threshold in diabetic mice, reaching a peak on week 2 after streptozocin injection and declining significantly afterwards. The seizure threshold in 8-week diabetic mice was even lower than control levels, though the difference was not significant. The K(ATP) channel opener cromakalim (0.1-30microg/kg, i.p.) significantly increased the seizure threshold in control mice. Although the K(ATP) channel blocker glibenclamide (0.5, 1mg/kg) had no effect, it prevented the effects of the potent dose of cromakalim (30microg/kg) on seizure threshold in control mice. Glibenclamide (1mg/kg, i.p.) also decreased the seizure threshold in 2-week diabetic mice to the control levels which was blocked by pre-treatment with cromakalim (10microg/kg, i.p.). Cromakalim (10microg/kg, i.p.) significantly increased the seizure threshold in 8-week diabetic mice which was inhibited by pre-treatment with glibenclamide (1mg/kg, i.p.). We demonstrated a time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice. This phenomenon might be due to the probable alteration in the K(ATP) channel functioning during the diabetic condition.

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Section: Discussionmentioning

confidence: 99%

ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice

Ghasemi

Shafaroodi

Karimollah

et al. 2010

Seizure

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show abstract

“…It has been shown that K ATP channels play a significant role in the regulation of seizure threshold in several in vitro and in vivo models (13,14,25). In addition, K ATP channel openers have been shown to decrease excitability in CA3 hippocampal 4 Arch Neurosci.…”

Section: Treatmentmentioning

confidence: 99%

RETRACTED ARTICLE: Cromakalim, a Potassium Channel Opener, Ameliorates Organophosphate- and Carbamate-Induced Seizures in Mice

et al. 2017

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Background: Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and death. The anticonvulsant properties of potassium channel openers, including cromakalim, have been determined in previous studies. Methods: In the present experiment, the possible effects of cromakalim on convulsion and death, induced by OPs and carbamates, were studied in mice. Dichlorvos as an OP compound (50 mg/kg) and physostigmine as a carbamate (2 mg/kg) were used to induce seizure in animals.

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“…Low ATP degree open these channels, letting K + efflux and cell hyperpolarization [20]. Pharmacological experiments have shown that K ATP channels play a significant role in the regulation of seizure threshold in several in vitro and in vivo models [6, 7, 21]. K ATP channels opener has been displayed to decrease excitability in CA3 hippocampal cells [22] and to show antiepileptic effects in a model of drug-induced epilepsia [23].…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant Effect of Diazoxide against Dichlorvos‐Induced Seizures in Mice

Jazayeri

Zolfaghari

Ostadhadi

2013

The Scientific World Journal

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Dichlorvos, a synthetic organophosphate toxin, is used as pesticides. These toxins can be used as pesticides in farming and medicine for the devastation and/or elimination of ectoparasites of animals. Reports have shown that Dichlorvos generate seizure effects in various animals. Potassium channel opener is extensively used for medication of cardiovascular and other diseases. Studies have shown that potassium channel opener has anticonvulsant effects in different animal models. The goal of this study was to evaluate the effect of dizoxide on Dichlorvos-induced seizures in mice. In this research, the animals received different doses of Diazoxide (1, 2.5, 5, 10, and 20 mg/kg b.wt.) intraperitoneally 30 min before intraperitoneal injection of Dichlorvos (50 mg/kg b.w.t). After Dichlorvos injection, latency of clones, severity of seizure, and finally death as the fate were investigated. Results showed that Diazoxide dose-dependently decreased the severity of Dichlorvos-induced seizures, so that Diazoxide at a dose of 5 mg (the lowest, P < 0.05) and 20 mg/kg b.wt. (the highest, P < 0.001) has anticonvulsant effects. Thus, our data suggest that diazoxide as ATP-sensitive potassium channels opener has anticonvulsant activity against dichlorvas-induced seizure.

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Anti- and proconvulsive actions of levcromakalim, an opener of ATP-sensitive K+ channel, in the model of hippocampus-generating partial seizures in rats

Cited by 15 publications

References 28 publications

ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice

ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice

RETRACTED ARTICLE: Cromakalim, a Potassium Channel Opener, Ameliorates Organophosphate- and Carbamate-Induced Seizures in Mice

Anticonvulsant Effect of Diazoxide against Dichlorvos‐Induced Seizures in Mice

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