Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action

Park, Jin Ju; An, Junmin; Lee, Jung Dae; Kim, Hyang Yeon; Im, Jueng Eun; Lee, Eun-Young; Ha, Jaehyoun; Cho, Chang Hui; Seo, Dong‐Wan; Kim, Kyu‐Bong

doi:10.1080/15287394.2020.1777492

Cited by 9 publications

(6 citation statements)

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“…The collagen fiber in the ECM comprises about 90% of the dermis 18 . Collagen fibers are degraded by diverse factors including generation of reactive oxygen species, photo‐aging 19 . Collagen may be metabolized by collagenases or matrix metalloproteinases (MMPs), which are endopeptidases a family of enzymes that breaks down collagen 20 …”

Section: Discussionmentioning

confidence: 99%

“… 18 Collagen fibers are degraded by diverse factors including generation of reactive oxygen species, photo‐aging. 19 Collagen may be metabolized by collagenases or matrix metalloproteinases (MMPs), which are endopeptidases a family of enzymes that breaks down collagen. 20 The synthesis of collagen is activated by the appearance of wrinkles to improve through collagen production or inhibition of MMPs.…”

Section: Discussionmentioning

confidence: 99%

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Anti‐wrinkle properties of Angelica gigas Nakai root extracts using mineral‐rich water

Kang

Cho²,

Choi

et al. 2022

J of Cosmetic Dermatology

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Background Angelica gigas Nakai is used as an herbal pharmaceutical material in Korea. Aims To investigate the anti‐wrinkle effects of A. gigas Nakai root extracts (ARE) using mineral‐rich water in in vitro and clinical trials. Materials and methods The cell viability of ARE was evaluated using a water‐soluble tetrazolium salt assay. After evaluating ARE's cytotoxicity, we used an enzyme‐linked immunosorbent assay kit to assess the effects of ARE on type I collagen in human dermal fibroblasts (HDFs). During a double‐blinded in vivo clinical study, participants were randomly assigned to use the sample and placebo formulations for the left and right sides of their face over an 8‐week period. We evaluated the anti‐wrinkle properties of the formulations using PRIMOS Lite and a global photodamage score. Results A. gigas Nakai root extracts cytotoxicity was evaluated in HDFs. We demonstrate that ARE increased type I collagen production by 40% at 50 μg/ml as compared with the control. The use of an ARE lotion significantly reduced the presence of crow's feet wrinkles in comparison with the use of the placebo after 8 weeks. Additionally, use of the ARE lotion led to decreased photodamage scores, indicating anti‐wrinkle effects. Conclusion The use of ARE with mineral‐rich water has anti‐wrinkle effects in in vitro and clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti‐wrinkle properties of Angelica gigas Nakai root extracts using mineral‐rich water

Kang

Cho²,

Choi

et al. 2022

J of Cosmetic Dermatology

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“…The anti-wrinkle effect of FBG results in induction of type I collagen synthesis and inhibition of MMP-1 activity. FBG reduces melanogenesis by inhibiting tyrosinase and reduces oxidation of DOPA, leading to skin whitening properties [ 42 ].…”

Section: Overview Of Biofermentsmentioning

confidence: 99%

Biological and Cosmetical Importance of Fermented Raw Materials: An Overview

2022

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The cosmetics industry is currently looking for innovative ingredients with higher bioactivity and bioavailability for the masses of natural and organic cosmetics. Bioferments are innovative ingredients extracted from natural raw materials by carrying out a fermentation process with appropriate strains of microorganisms. The review was conducted using the SciFinder database with the keywords “fermented plant”, “cosmetics”, and “fermentation”. Mainly bioferments are made from plant-based raw materials. The review covers a wide range of fermented raw materials, from waste materials (whey with beet pulp) to plant oils (F-Shiunko, F-Artemisia, F-Glycyrrhiza). The spectrum of applications for bioferments is broad and includes properties such as skin whitening, antioxidant properties (blackberry, soybean, goji berry), anti-aging (red ginseng, black ginseng, Citrus unshiu peel), hydrating, and anti-allergic (aloe vera, skimmed milk). Fermentation increases the biochemical and physiological activity of the substrate by converting high-molecular compounds into low-molecular structures, making fermented raw materials more compatible compared to unfermented raw materials.

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Section: Ginsengmentioning

confidence: 99%

Biological and Cosmetical Importance of Fermented Raw Materials: An Overview

Majchrzak¹,

Motyl²,

Śmigielski³

2022

Preprint

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The cosmetics industry is currently looking for innovative ingredients with higher bioactivity and bioavailability for the masses of natural and organic cosmetics. Bioferments are innovative ingredients extracted from natural raw materials by carrying out a fermentation process with appropriate strains of microorganisms. The review was conducted using the SciFinder database with the keywords fermented plant, cosmetics, fermentation. Mainly bioferments are made from plant-based raw materials. The review covers a wide range of fermented raw materials from waste materials (whey with beet pulp) to plant oils (F-Shiunko, F-Artemisia, F-Glycyrrhiza). The spectrum of applications for bioferments is broad and includes properties such as skin whitening, antioxidant properties (blackberry, soybean, goji berry), anti-ageing, anti-aging (red ginseng, black ginseng, Citrus unshiu peel), hydrating and anti-allergic (aloe vera, skimmed milk). Fermentation increases the biochemical and physiological activity of the substrate by converting high-molecular compounds into low-molecular structures, this makes fermented raw materials more compatible compared to unfermented raw materials.

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Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action

Cited by 9 publications

References 50 publications

Anti‐wrinkle properties of Angelica gigas Nakai root extracts using mineral‐rich water

Anti‐wrinkle properties of Angelica gigas Nakai root extracts using mineral‐rich water

Biological and Cosmetical Importance of Fermented Raw Materials: An Overview

Biological and Cosmetical Importance of Fermented Raw Materials: An Overview

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