Effects of anti-aging interventions on intestinal microbiota

Du, Yanjiao; Gao, Yue; Zeng, Bo; Fan, Xiaolan; Yang, Deying; Yang, Mingyao

doi:10.1080/19490976.2021.1994835

Cited by 50 publications

(40 citation statements)

References 147 publications

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“…FMT from the obesity-associated human gut microbiota to mice can induce vascular dysfunction and glucose intolerance, and FMT from lean donors to patients with obesity can promote metabolic benefits (Mocanu et al, 2021;Russo et al, 2021). Recent studies over the past decade have revealed that many environmental factors, including diet, antibiotic exposure, energy intake and exercise, can dramatically influence the gut microbiota (Du et al, 2021;Giordan et al, 2021;Shi et al, 2021). Dietary fiber has been shown to improve obesity and is considered a potential therapy because it increases microbial fermentation of SCFAs (Schäfer et al, 2021;Thomson et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Polydextrose Alleviates Adipose Tissue Inflammation and Modulates the Gut Microbiota in High-Fat Diet-Fed Mice

Niu

Yang

et al. 2022

Front. Pharmacol.

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The soluble dietary fiber polydextrose (PDX) is a randomly linked glucose oligomer containing small amounts of sorbitol and citric acid and is widely used in the food industry. However, whether PDX can prevent and treat obesity in high-fat diet (HFD)-fed mice has not been directly investigated, and further studies are needed to better understand the complex interactions among PDX, adipose tissue inflammation and the gut microbiota. In the present study, PDX reduced body weight, fasting blood glucose (FBG), adipose tissue accumulation, adipocyte hypertrophy, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels in HFD-fed mice. Moreover, PDX alleviated serum lipopolysaccharide (LPS) levels and macrophage infiltration in epididymal adipose tissue and resulted in macrophage polarization toward the M2 phenotype. Gut microbiota analysis revealed that PDX promoted the growth of beneficial microbes such as Bacteroides, Parabacteroides, Alloprevotella, Muribaculum, Akkermansia, Ruminococcaceae_UCG-014 and UBA1819 in obese mice, which were negatively correlated with subcutaneous fat, epididymal fat, body weight, FBG, serum TC, HDL-C, LDL-C and LPS levels. Our results indicates that PDX can prevent and treat obesity in HFD-fed mice, specifically in alleviating glucolipid metabolism disorders and adipose tissue inflammation, which may be mediated by modulating the structure of the gut microbiota. Therefore, PDX may become a promising nondrug therapy for obesity.

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Section: Discussionmentioning

confidence: 99%

Polydextrose Alleviates Adipose Tissue Inflammation and Modulates the Gut Microbiota in High-Fat Diet-Fed Mice

Niu

Yang

et al. 2022

Front. Pharmacol.

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“…Thus, the use of probiotics is useful to inhibit the aging process through modulating the immune response, antioxidant defense, and sirtuins [286]. The effects of anti-aging interventions on the population and environment of gut microbiota were discussed in this paper [287]. Probiotics were also considered as anti-aging effectors in skin issues and dermatology [288].…”

Section: Pharmacological and Nutraceutical Interventionsmentioning

confidence: 99%

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

et al. 2022

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Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role of MSCs in tissue homeostasis, aging-related diseases, and cellular therapy is clinically suggested. As aging is a universal problem that has large socioeconomic effects, an improved understanding of the concepts of aging can direct public policies that reduce its adverse impacts on the healthcare system and humanity. Several studies of aging have been carried out over several years to understand the phenomenon and different factors affecting human aging. A reduced ability of adult stem cell populations to reproduce and regenerate is one of the main contributors to the human aging process. In this context, MSCs senescence is a major challenge in front of cellular therapy advancement. Many factors, ranging from genetic and metabolic pathways to extrinsic factors through various cellular signaling pathways, are involved in regulating the mechanism of MSC senescence. To better understand and reverse cellular senescence, this review highlights the underlying mechanisms and signs of MSC cellular senescence, and discusses the strategies to combat aging and cellular senescence. Graphical Abstract

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“…The overall structure and function of the intestinal microbiota are stable for a period of time, but they are highly sensitive to changes in internal and external environments. Exogenous factors such as diet, exposure to bacterial infections or taking drugs can reduce the diversity of the intestinal microbiota; endogenous factors such as acute body fluid imbalance, chronic intestinal congestion or ischemia hypoxia, acid-base imbalance, gastrointestinal weakened exercise and nutritional deficiencies can potentially change the intestinal microbiota [40][41][42][43][44]. Therefore, it is necessary and meaningful to summarize the changes of intestinal microbiota and its metabolites caused by intestinal I/R and the role of intestinal microbiota and its metabolites in intestinal I/R injury.…”

Section: Overview Of the Intestinal Microbiotamentioning

confidence: 99%

The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury

Deng¹,

Lin²,

Sun³

et al. 2022

Int. J. Biol. Sci.

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Intestinal ischemia/reperfusion (I/R) is a common pathophysiological process in clinical severe patients, and the effect of intestinal I/R injury on the patient's systemic pathophysiological state is far greater than that of primary intestinal injury. In recent years, more and more evidence has shown that intestinal microbiota and its metabolites play an important role in the occurrence, development, diagnosis and treatment of intestinal I/R injury. Intestinal microbiota is regulated by host genes, immune response, diet, drugs and other factors. The metabolism and immune potential of intestinal microbiota determine its important significance in host health and diseases. Therefore, targeting the intestinal microbiota and its metabolites may be an effective therapy for the treatment of intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury. This review focuses on the role of intestinal microbiota and its metabolites in intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury, and summarizes the latest progress in regulating intestinal microbiota to treat intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury.

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Effects of anti-aging interventions on intestinal microbiota

Cited by 50 publications

References 147 publications

Polydextrose Alleviates Adipose Tissue Inflammation and Modulates the Gut Microbiota in High-Fat Diet-Fed Mice

Polydextrose Alleviates Adipose Tissue Inflammation and Modulates the Gut Microbiota in High-Fat Diet-Fed Mice

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury

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