Effects of anterior thalamic nuclei deep brain stimulation on neurogenesis in epileptic and healthy rats

Chen, Ying; Shi, Lin; Zhu, Guanyu; Wang, Xiu; Liu, Defeng; Liu, Yu-Ye; Jiang, Yin; Zhang, Xin; Zhang, Jianguo

doi:10.1016/j.brainres.2017.07.021

Cited by 17 publications

(13 citation statements)

References 41 publications

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“…There are also several studies demonstrating that DBS has a therapeutic effect in a rat stroke model [33,34]. DBS of other cerebral structures, such as the anterior thalamic nuclei [35] or fastigial nucleus [36], also resulted in neuroprotection. Similarly, as presented here, HFS of the MLR reduced neuronal apoptosis in the perilesional region after experimental stroke, which indicates, that even DBS of these remote cerebral regions results in neuroprotection.…”

Section: Discussionmentioning

confidence: 99%

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Electrical Stimulation of the Mesencephalic Locomotor Region Attenuates Neuronal Loss and Cytokine Expression in the Perifocal Region of Photothrombotic Stroke in Rats

Schuhmann

Stoll

Bohr

et al. 2019

IJMS

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Deep brain stimulation of the mesencephalic locomotor region (MLR) improves the motor symptoms in Parkinson’s disease and experimental stroke by intervening in the motor cerebral network. Whether high-frequency stimulation (HFS) of the MLR is involved in non-motor processes, such as neuroprotection and inflammation in the area surrounding the photothrombotic lesion, has not been elucidated. This study evaluates whether MLR-HFS exerts an anti-apoptotic and anti-inflammatory effect on the border zone of cerebral photothrombotic stroke. Rats underwent photothrombotic stroke of the right sensorimotor cortex and the implantation of a microelectrode into the ipsilesional MLR. After intervention, either HFS or sham stimulation of the MLR was applied for 24 h. The infarct volumes were calculated from consecutive brain sections. Neuronal apoptosis was analyzed by TUNEL staining. Flow cytometry and immunohistochemistry determined the perilesional inflammatory response. Neuronal apoptosis was significantly reduced in the ischemic penumbra after MLR-HFS, whereas the infarct volumes did not differ between the groups. MLR-HFS significantly reduced the release of cytokines and chemokines within the ischemic penumbra. MLR-HFS is neuroprotective and it reduces pro-inflammatory mediators in the area that surrounds the photothrombotic stroke without changing the number of immune cells, which indicates that MLR-HFS enables the function of inflammatory cells to be altered on a molecular level.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have addressed this issue. HFS of the hippocampus, subthalamic, and anterior thalamic nucleus diminished the apoptosis-related proteins and consequently reduced neuronal loss [32,35,52]. HFS of the anterior thalamic nucleus was further associated with the attenuated expression of pro-inflammatory cytokines [53].…”

Section: Discussionmentioning

confidence: 99%

Electrical Stimulation of the Mesencephalic Locomotor Region Attenuates Neuronal Loss and Cytokine Expression in the Perifocal Region of Photothrombotic Stroke in Rats

Schuhmann

Stoll

Bohr

et al. 2019

IJMS

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“…Although controversial, approaches to reduce neuronal cell loss may decrease seizure frequency [ 56 , 94 ]. ANT-DBS has been shown to increase neurogenesis in the chronic stage of ANT-DBS in KA-induced seizures in rats as shown by an increased expression of Ki-67 and DCX [ 10 ]. The model of prolonged neurogenesis could further explain the observation of an increased efficacy of ANT-DBS in the long-term follow-up of the SANTE trial.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Deep brain stimulation of the anterior nucleus of the thalamus for drug-resistant epilepsy

et al. 2018

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Despite the use of first-choice anti-epileptic drugs and satisfactory seizure outcome rates after resective epilepsy surgery, a considerable percentage of patients do not become seizure free. ANT-DBS may provide for an alternative treatment option in these patients. This literature review discusses the rationale, mechanism of action, clinical efficacy, safety, and tolerability of ANT-DBS in drug-resistant epilepsy patients. A review using systematic methods of the available literature was performed using relevant databases including Medline, Embase, and the Cochrane Library pertaining to the different aspects ANT-DBS. ANT-DBS for drug-resistant epilepsy is a safe, effective and well-tolerated therapy, where a special emphasis must be given to monitoring and neuropsychological assessment of both depression and memory function. Three patterns of seizure control by ANT-DBS are recognized, of which a delayed stimulation effect may account for an improved long-term response rate. ANT-DBS remotely modulates neuronal network excitability through overriding pathological electrical activity, decrease neuronal cell loss, through immune response inhibition or modulation of neuronal energy metabolism. ANT-DBS is an efficacious treatment modality, even when curative procedures or lesser invasive neuromodulative techniques failed. When compared to VNS, ANT-DBS shows slightly superior treatment response, which urges for direct comparative trials. Based on the available evidence ANT-DBS and VNS therapies are currently both superior compared to non-invasive neuromodulation techniques such as t-VNS and rTMS. Additional in-vivo research is necessary in order to gain more insight into the mechanism of action of ANT-DBS in localization-related epilepsy which will allow for treatment optimization. Randomized clinical studies in search of the optimal target in well-defined epilepsy patient populations, will ultimately allow for optimal patient stratification when applying DBS for drug-resistant patients with epilepsy.

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“…A previous study reported an increase in NPCs in the SVZ associated with subthalamic nuclei DBS in patients with Parkinson’s disease 35 . Preclinical studies have also demonstrated anti-epilepsy effects, antidepressant/anxiolytic responses and memory improvements by DBS correlated with neurogenesis 36 – 38 . Even so, adult neurogenesis is very species-specific, and the occurrence of neurogenesis in humans needs more critical thinking.…”

Section: Discussionmentioning

confidence: 98%

Electrical stimulation of the lateral cerebellar nucleus promotes neurogenesis in rats after motor cortical ischemia

Sun

et al. 2020

Sci Rep

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Deep brain stimulation (DBS) has been tentatively explored to promote motor recovery after stroke. Stroke could transiently activate endogenous self-repair processes, including neurogenesis in the subventricular zone (SVZ). In this regard, it is of considerable clinical interest to study whether DBS of the lateral cerebellar nucleus (LCN) could promote neurogenesis in the SVZ for functional recovery after stroke. In the present study, rats were trained on the pasta matrix reaching task and the ladder rung walking task before surgery. And then an electrode was implanted in the LCN following cortical ischemia induced by endothelin-1 injection. After 1 week of recovery, LCN DBS coupled with motor training for two weeks promoted motor function recovery, and reduced the infarct volumes post-ischemia. LCN DBS augmented poststroke neurogenetic responses, characterized by proliferation of neural progenitor cells (NPCs) and neuroblasts in the SVZ and subsequent differentiation into neurons in the ischemic penumbra at 21 days poststroke. DBS with the same stimulus parameters at 1 month after ischemia could also increase nascent neuroblasts in the SVZ and newly matured neurons in the perilesional cortex at 42 days poststroke. These results suggest that LCN DBS promotes endogenous neurogenesis for neurorestoration after cortical ischemia.

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Effects of anterior thalamic nuclei deep brain stimulation on neurogenesis in epileptic and healthy rats

Cited by 17 publications

References 41 publications

Electrical Stimulation of the Mesencephalic Locomotor Region Attenuates Neuronal Loss and Cytokine Expression in the Perifocal Region of Photothrombotic Stroke in Rats

Electrical Stimulation of the Mesencephalic Locomotor Region Attenuates Neuronal Loss and Cytokine Expression in the Perifocal Region of Photothrombotic Stroke in Rats

Deep brain stimulation of the anterior nucleus of the thalamus for drug-resistant epilepsy

Electrical stimulation of the lateral cerebellar nucleus promotes neurogenesis in rats after motor cortical ischemia

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