Effects of Anoxia on Pressure, Resistance and Blood (P<sup>32</sup>) Volume of Pulmonary Vessels

Aviado, Domingo M.; Cerletti, A; Alanís, J; Bulle, Peter H.; Schmidt, Carl F.

doi:10.1152/ajplegacy.1952.169.2.460

Cited by 48 publications

(12 citation statements)

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“…Aviado and his associates, 11 working with anesthetized dogs, corroborated previous findings that pulmonary arterial pressure rises both in animals breathing naturally and under artificial respiration. However, through supplementary experiments involving (a) responses following denervation of the carotid sinus and aorta, and (b) controlled perfusion of one of the lungs, they consistently found that anoxemia, per se, reduces pulmonary arterial resistance, and that the rise of pulmonary arterial pressure must be assigned to increased pulmonary blood flow, that is, increased right ventricular output.…”

supporting

confidence: 72%

The Effects of Progressive General Anoxia on the Pulmonary Circulation

Hürlimann

Wiggers

1953

Circulation Research

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supporting

confidence: 72%

The Effects of Progressive General Anoxia on the Pulmonary Circulation

Hürlimann

Wiggers

1953

Circulation Research

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“…15 yr ago it was suggested that the catecholamines were involved in this response (1,2). Subsequent investigations have been inconclusive in either supporting or refuting this hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia

Silove¹,

Grover²

1968

J. Clin. Invest.

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A B S T R A C T The highly reactive pulmonary vascular bed of the neonatal calf was utilized to determine whether the hypoxic pulmonary pressor response is modified by a-adrenergic blockade with phenoxybenzamine (Group A) or by tissue catecholamine depletion with reserpine (Group B). In addition, in Group A, the effects of hypoxia on the pulmonary circulation were compared and contrasted with those of l-norepinephrine (a-receptor stimulator) and isoproterenol (,8-receptor stimulator).In Group A, changes in pulmonary vascular resistance were calculated from measurements of appropriate pressures and of pulmonary blood flow (electromagnetic flowmeter). The increase in pulmonary vascular resistance produced by hypoxia was not diminished by a-adrenergic blockade. However, blockade abolished the pulmonary vasoconstrictor effect of norepinephrine. During hypoxic pulmonary vasoconstriction, the administration of either norepinephrine or isoproterenol lowered the pulmonary vascular resistance both before and after a-blockade. 25 September 1967. sels secondary to an increased pulmonary blood flow.The pulmonary vascular response to hypoxia in the reserpinized calves (Group B) was tested under three circumstances: (1) in the awake animal, (2) in the anesthetized animal prepared in the same way as those in Group A, and (3) during constant flow perfusion of the left lower lobe pulmonary artery. From these studies it was concluded that tissue catecholamine depletion did not diminish the pulmonary vascular response to hypoxia.Thus, neither a-adrenergic blockade nor tissue catecholamine depletion prevents the hypoxic pulmonary pressor response. Furthermore, a-blockade prevents the pulmonary vasoconstrictor response to norepinephrine but not to hypoxia. Therefore it is concluded that hypoxic pulmonary vasoconstriction is not mediated through adrenergic receptor stimulation or release of endogenous catecholamines.

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“…It has been suggested that the catecholamines may be involved in this pressor response (6,7). However, it is uncertain if this hypothesis applies to the effects of tolerable levels of hypoxia in man, since the experimental evidence for enhanced adrenal activity derives exclusively from observations made during severe hypoxia and asphyxia in animals (8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

The Catecholamines in the Pulmonary Arterial Pressor Response to Acute Hypoxia*

Goldring¹,

Turino²,

Cohen³

et al. 1962

J. Clin. Invest.

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Effects of Anoxia on Pressure, Resistance and Blood (P³²) Volume of Pulmonary Vessels

Cited by 48 publications

References 0 publications

The Effects of Progressive General Anoxia on the Pulmonary Circulation

The Effects of Progressive General Anoxia on the Pulmonary Circulation

Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia

The Catecholamines in the Pulmonary Arterial Pressor Response to Acute Hypoxia*

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Effects of Anoxia on Pressure, Resistance and Blood (P32) Volume of Pulmonary Vessels

Cited by 48 publications

References 0 publications

The Effects of Progressive General Anoxia on the Pulmonary Circulation

The Effects of Progressive General Anoxia on the Pulmonary Circulation

Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia

The Catecholamines in the Pulmonary Arterial Pressor Response to Acute Hypoxia*

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Effects of Anoxia on Pressure, Resistance and Blood (P³²) Volume of Pulmonary Vessels