Effects of Ankaferd Blood Stopper and Celox on the Tissue Factor Activities of Warfarin-Treated Rats

Aktop, Sertaç; Emekli-Alturfan, Ebru; Özer, Cüneyt; Gönül, Onur; Garip, Hasan; Yarat, Ayşen; Göker, Kamil

doi:10.1177/1076029613490254

Cited by 24 publications

(29 citation statements)

References 45 publications

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“…ABS has been used as a local haemostatic agent in surgery, but it was also shown to promote healing (5,9). Its effects on soft-tissue healing have been investigated (17,(19)(20)(21), but not in a STZ model of diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidation of membrane polyunsaturated fatty acids disrupts cell structure and function and induces cytotoxic, hepatotoxic, mutagenic, and genotoxic effects related to the release of aldehydes (4,5).…”

Section: Introductionmentioning

confidence: 99%

“…In humans, GSH concentrations are highest in the liver; in hepatocytes, GSH accounts for 90% of nonprotein sulfhydryl groups. As an important reducing agent and antioxidant, GSH maintains the cellular oxidoreduction balance and protects cells against the toxic effects of oxidants, whether of endogenous or exogenous origin (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…ABS is not only an effective haemostatic agent but also exhibits tissue antioxidant properties (5,9). In Turkey, ABS is approved for the management of postsurgical dental bleeding and external haemorrhage (5).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have shown that ABS promotes tissue healing (5,9,(16)(17)(18)(19)(20)(21). Therefore, in this study, we addressed the effectiveness of ABS in diabetes, in which wound healing is severely impaired.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Ankaferd BloodStopper on dermal healing in diabetic rats

Aktop¹,

Çevreli²,

Genç³

et al. 2017

Turk J Med Sci

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IntroductionDiabetes mellitus (DM) is a chronic, life-long metabolic disease occurring worldwide. Affected individuals require continuous follow-up and suffer numerous disease-related complications. The high levels of blood glucose that characterise DM contribute to an increase in free radical production, enhanced oxidative stress, and changes in antioxidant capacity (1-3).Streptozotocin (STZ) is the chemical agent most frequently used to induce experimental diabetes in animal models. By binding to glucose receptors in the plasma membrane, STZ blocks glucose-induced insulin secretion (2,3) and alters blood insulin and glucose concentrations.Among the many effects of free radical production is lipid peroxidation (LPO). Oxidation of membrane polyunsaturated fatty acids disrupts cell structure and function and induces cytotoxic, hepatotoxic, mutagenic, and genotoxic effects related to the release of aldehydes (4,5).The tripeptide glutathione (GSH) is found in the cells of all organisms. In humans, GSH concentrations are highest in the liver; in hepatocytes, GSH accounts for 90% of nonprotein sulfhydryl groups. As an important reducing agent and antioxidant, GSH maintains the cellular oxidoreduction balance and protects cells against the toxic effects of oxidants, whether of endogenous or exogenous origin (5-7).Ankaferd BloodStopper (ABS) (Ankaferd Health Products Ltd., İstanbul, Turkey) is a medicinal extract from the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica (7,8). ABS is not only an effective haemostatic agent but also Background/aim: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats. Materials and methods:The 24 Wistar albino rats used in this study were divided into STZ-treated (STZ, n = 12) and nontreated groups (control, n = 12). Four days prior to surgery, rats in the STZ group were subcutaneously administered 60 mg/kg STZ intraperitoneally, while rats in the control group were administered 1 mL saline/kg. An incision was made in the dorsal dermal tissue of all rats, and either ABS or no haemostatic agent (NHAA) was applied to the wound before suturing. All of the rats were euthanised on postoperative day 4. Blood and skin samples were evaluated biochemically and histologically. Results:The results showed that STZ treatment impaired soft-tissue healing, assessed by measuring glutathione and lipid peroxidation levels. Moreover, while good histological results were obtained in the control group treated with ABS, there were fewer benefits in the STZ-treated group. Conclusion:AB...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Ankaferd BloodStopper on dermal healing in diabetic rats

Aktop¹,

Çevreli²,

Genç³

et al. 2017

Turk J Med Sci

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Hämostyptika zur Behandlung der „junctional vascular injuries“

2018

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It was the military that in addition to the development of special tourniquets, intensified research programs and the implementation of hemostatic devices and dressings in this anatomical region. This article deals with junctional vascular injuries at the transition between the trunk and the extremities. In addition to the anatomical situation, this article gives the reader an overview of the currently available hemostyptics and their mode of action.

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