Effects of anisatin on the GABA action in the crayfish neuromuscular junction

Shinozaki, H.; Ishida, Michiko; Kudo, Yoshihisa

doi:10.1016/0006-8993(81)91044-1

Cited by 22 publications

(9 citation statements)

References 13 publications

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“…Previous studies suggested that the apparent neuropharmacological actions of anisatin were similar to those of picrotoxin ( Curtis et al ., 1973 ; Kudo et al ., 1981 ; Shinozaki et al ., 1981 ; Walker & Roberts, 1984 ; Scott & Duce, 1987 ). Thus, the site of action of anisatin may be the same as that of picrotoxin.…”

Section: Resultsmentioning

confidence: 99%

“…Anisatin is known to be a noncompetitive GABA antagonist ( Kudo et al ., 1981 ; Shinozaki et al ., 1981 ; Walker & Roberts, 1984 ; Scott & Duce, 1987 ). When anisatin was repeatedly co‐applied with GABA for 5 s, the current was suppressed gradually (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…One of the toxic substances isolated from Sikimi plant is anisatin ( Lane et al ., 1952 ; Yamada et al ., 1968 ). Neuropharmacological studies conducted with the frog spinal cord and crude synaptic membranes isolated from the rat whole brain showed that anisatin was a potent non‐competitive GABA antagonist ( Kudo et al ., 1981 ; Shinozaki et al ., 1981 ). However, little is known about the mechanism of action of anisatin on the GABA system at the ion channel level.…”

Section: Introductionmentioning

confidence: 99%

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Anisatin modulation of the γ‐aminobutyric acid receptor‐channel in rat dorsal root ganglion neurons

Ikeda

Ozoe

Okuyama

et al. 1999

British J Pharmacology

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1 Anisatin, a toxic, insecticidally active component of Sikimi plant, is known to act on the GABA system. In order to elucidate the mechanism of anisatin interaction with the GABA system, wholecell and single-channel patch clamp experiments were performed with rat dorsal root ganglion neurons in primary culture. 2 Repeated co-applications of GABA and anisatin suppressed GABA-induced whole-cell currents with an EC 50 of 1.10 mM. No recovery of currents was observed after washout with anisatin-free solution.3 However, pre-application of anisatin through the bath had no eect on GABA-induced currents. The decay phase of currents was accelerated by anisatin. These results indicate that anisatin suppression of GABA-induced currents requires opening of the channels and is use-dependent. 4 Anisatin suppression of GABA-induced currents was not voltage dependent. 5 Picrotoxinin attenuated anisatin suppression of GABA-induced currents. [ 3 H]-EBOB binding to rat brain membranes was competitively inhibited by anisatin. These data indicated that anisatin bound to the picrotoxinin site. 6 At the single-channel level, anisatin did not alter the open time but prolonged the closed time. The burst duration was reduced and channel openings per burst were decreased indicating that anisatin decreased the probability of openings.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anisatin modulation of the γ‐aminobutyric acid receptor‐channel in rat dorsal root ganglion neurons

Ikeda

Ozoe

Okuyama

et al. 1999

British J Pharmacology

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“…4 Although I verum is considered safe for consumption, this species also contains the toxic compounds, veranisatin A, B, and C. 7 Anisatin compounds are thought to act as picrotoxin-like noncompetitive ␥-aminobutyric acid (GABA) antagonists. 8 The mass spectral pattern of each sample was similar in the number, type, and concentration of these compounds. Extracts from the third case, however, suggested the presence of an Illicium species other than I verum.…”

Section: Chemical Composition Of Chinese Star Anise (Illicium Verum) mentioning

confidence: 88%

Chemical Composition of Chinese Star Anise (Illicium verum) and Neurotoxicity in Infants

Ize-Ludlow

Ragone

Bernstein

et al. 2004

JAMA: The Journal of the American Medical Association

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“…15 Anisatin compounds are thought to act as potent noncompetitive ␥-aminobutyric acid antagonists. [16][17][18][19][20] Concern has been raised regarding the adulteration of I verum with I anisatum and has led to recalls of these products in other countries, including Spain, France, Scotland, China, Japan, and Netherlands. [21][22][23] In this communication, we report 7 cases of adverse neurologic reactions associated with the home administration of star anise tea to young infants seen during the past 2 years at Miami Children's Hospital.…”

mentioning

confidence: 99%

Neurotoxicities in Infants Seen With the Consumption of Star Anise Tea

et al. 2004

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ABSTRACT. Chinese star anise (Illicium verum Hook f.) is a well-known spice used in many cultures. Many populations use it as a treatment for infant colic. Japanese star anise (Illicium anisatum L), however, has been documented to have both neurologic and gastrointestinal toxicities. Recently, concern has been raised regarding the adulteration of Chinese star anise with Japanese star anise. We report 7 cases of adverse neurologic reactions in infants seen with the home administration of star anise tea. In addition, we have found evidence that Chinese star anise has been contaminated with Japanese star anise. More strict federal regulation of the import of star anise into the United States is warranted. Star anise tea should no longer be administered to infants because of its potential danger in this population. ABBREVIATION. GC-MS, gas chromatography-mass spectroscopy. C hinese star anise (Illicium verum Hook f.) is a well-known spice used in many cultures. Caribbean and Latino populations typically use a tea infusion of its 8-pointed stellate fruit (Fig 1) as a carminative and sedative for the treatment of infant colic. Because of its long history of herbal and culinary uses, Chinese star anise has been commonly regarded as being safe and nontoxic. A closely related species, Japanese star anise (Illicium anisatum L, syn. I japonicum Sieb, syn. I religiosum Sieb et Zucc), has been well documented to cause both neurologic and gastrointestinal toxicities. [1][2][3][4][5] All Illicium species contain sesquiterpene lactone compounds, 6-12 a large and diverse group of biologically active plant chemicals, most containing a number of secondary metabolite products related to anisatin, neoanisatin, and pseudoanisatin, the potent neurotoxins found in Japanese star anise. 13,14 Although Chinese star anise is considered safe for consumption, this species also contains toxic compounds named veranisatins A, B, and C. 15 Although these veranisatins are not as potent as anisatin itself, neurologic symptoms are observed at higher doses. 15 Anisatin compounds are thought to act as potent noncompetitive ␥-aminobutyric acid antagonists. [16][17][18][19][20] Concern has been raised regarding the adulteration of I verum with I anisatum and has led to recalls of these products in other countries, including Spain, France, Scotland, China, Japan, and Netherlands. [21][22][23] In this communication, we report 7 cases of adverse neurologic reactions associated with the home administration of star anise tea to young infants seen during the past 2 years at Miami Children's Hospital. In addition, we have discovered adulteration of several of the Chinese star anise samples with I anisatum. METHODS Clinical CasesOver a 2-year period, infants with signs and symptoms of star anise intoxication were identified in the emergency department of Miami Children's Hospital. Miami Children's Hospital is a large, urban, pediatric teaching hospital with an emergency department that sees 87 000 patients per year. Signs and symptoms of star anise intoxicatio...

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Effects of anisatin on the GABA action in the crayfish neuromuscular junction

Cited by 22 publications

References 13 publications

Anisatin modulation of the γ‐aminobutyric acid receptor‐channel in rat dorsal root ganglion neurons

Anisatin modulation of the γ‐aminobutyric acid receptor‐channel in rat dorsal root ganglion neurons

Chemical Composition of Chinese Star Anise (Illicium verum) and Neurotoxicity in Infants

Neurotoxicities in Infants Seen With the Consumption of Star Anise Tea

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