Effects of anesthetics on cystometric parameters in female rats

Özkürkçügil, Cüneyd; Özkan, Levend

doi:10.1007/s11255-010-9745-4

Cited by 16 publications

(13 citation statements)

References 21 publications

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“…Although many kinds of rodents are considered suitable for urodynamic study, rats are most commonly used for the estimation of bladder storage and voiding functions in normal animals and disease models so far [3] . Considering the obvious impact of anesthesia on bladder function as previously reported [5,8,16,17] , it is widely suggested that urodynamic examination should, both in animals and humans, be carried out in a conscious state that is more close to the situation of everyday life.…”

Section: Discussionmentioning

confidence: 99%

“…Since anesthetics have been evidenced to apparently suppress micturition reflex actions, urodynamic examination is recommended, both in animals and humans, to be conducted in an awake state, which is more close to the regular situation of everyday life [3][4][5] . For conscious urodynamic investigation in rats, implantation of a catheter into the bladder prior to experiments is usually needed [3,6,7] .…”

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confidence: 99%

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Urodynamic characteristics of awake rats under retrained versus freely moving condition: Using a novel model

Chen

Zhang

Tian

et al. 2016

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Urodynamic investigation in conscious rats is widely employed to explore functional bladder disorders of various etiologies and pathogeneses. Rats can be placed in restraining cages or wide cabinets where they are allowed to move freely during cystometry. However, the requirements of special devices hampered the application of urodynamic test in freely moving rats, and whether the restraint has any effects on urodynamic parameters in conscious rats remains obscure. In the present study, we described a novel approach for urodynamic investigation in both restrained and freely moving conscious rats. In addition, we for the first time systematically compared the urodynamic parameters of rats in the two conditions. With the current method, we successfully recorded stable and repeatable intravesical pressure traces and collected expected reliable data, which supported the idea that the restraint does not affect the activity of the micturition reflex in rats, provided sufficient and appropriate measures could be applied during cystometry. Fewer technique problems were encountered during urodynamic examination in restrained rats than in freely moving ones. Taken together, conscious cystometry in rats placed in restraining cages with proper managements is a reliable and practical approach for evaluating the detrusor activity and bladder function.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Urodynamic characteristics of awake rats under retrained versus freely moving condition: Using a novel model

Chen

Zhang

Tian

et al. 2016

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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“…Ceran et al reported that midazolam depressed detrusor contraction at moderate and high concentrations in the study that they conducted to determine the effects of the commonly used anesthetic agents of ketamine, propofol and midazolam on rat detrusor smooth muscle in vitro (Ceran et al 2010). Another study investigated the effects of ketamine, propofol, midazolam and ether on cystometric parameters in rats and reported that the urination reflex disappears under ketamine anesthesia while propofol prolongs the urination period but ether inhalation and midazolam make no change in urodynamic parameters (Ozkurkcugil and Ozkan 2010). …”

Section: Discussionmentioning

confidence: 99%

“…Some studies report that the conscious sedation created by midazolam is appropriate and effective for many procedures and does not affect urodynamic measurements (Bozkurt et al 1996; Ozkurkcugil and Ozkan 2010). Conscious sedation can be defined as a constant sedation in an awake patient where protective airway reflexes are maintained.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of sedation administered via three different routes on the procedure, child and parent satisfaction during cystometry

2016

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PurposeIn this study, we retrospectively investigated case reports with and without midazolam administration via oral, intranasal and rectal before cystometry procedure. We aimed to compare the data to evaluate the effects of sedation before cystometry on the pediatric patients and parents’ satisfaction.MethodsA total of 124 ASA I-II pediatric cases aged 5–14 years were retrospectively investigated from the hospital records. One of the three administration routes was chosen; oral midazolam at a dose of 0.5 mg/kg and nasal or rectal midazolam at a dose of 0.3 mg/kg (maximum 15 mg). Heart rate, blood pressure, oxygen saturation, the Wisconsin Hospital of Children Sedation Scale (CHWSS) score and the Groningen Distress Rating Scale (GDRS) score were recorded. Cystometry measurement values, diagnoses of the cases and procedure durations were recorded from the urodynamic laboratory records.Results80 female, 44 male cases were evaluated. The CHWSS score at the 10th and 20th minutes after the drug administeration was higher in the oral group than the others (p = 0.001). The duration between the administration of the drug and the start of the procedure was shorter in the nasal group (p = 0.01). Parents satisfaction for sedation was 77 % when comparison of the cystometry with and without sedation. Comparison of the cystometry results with or without sedation no significant difference was found between all parameters (p > 0.01).ConclusionWe believe that sedation with midazolam administered through all three routes is a safe, effective and convenient option during cystometry, especially in the young age group.

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“…Ideally, the subject should be awake and unanaesthetized during these studies 1 . However anesthesia, which can confound urodynamic outcomes [2][3][4] , is often required in many animal models of urodynamic studies, particularly when treatments for bladder dysfunctions are being tested in experimental paradigms that require control over the animal's state.…”

Section: Introductionmentioning

confidence: 99%

Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines

Yousuf

Ouyang

et al. 2019

Preprint

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Urodynamic studies, used to understand bladder function, diagnose bladder disease, and develop treatments for dysfunctions, are ideally performed with awake subjects. However, in animal models, especially cats (a common model of spinal cord injury and associated bladder pathology), anesthesia is often required for these procedures and can be a research confounder. This study compared the effects of select agents (dexmedetomidine, alfaxalone, propofol, isoflurane, and α-chloralose) on urodynamic (Δpressure, bladder capacity, bladder compliance, non-voiding contractions, bladder pressure slopes) and anesthetic (change in heart rate [∆HR], average heart rate [HR], reflexes, induction/recovery times) parameters in repeated cystometrograms across five adult male cats. Δpressure was greatest with propofol, bladder capacity was highest with α-chloralose, non-voiding contractions were greatest with αchloralose. Propofol and dexmedetomidine had the highest bladder pressure slopes during the initial and final portions of the cystometrograms respectively. Cats progressed to a deeper plane of anesthesia (lower HR, smaller ΔHR, decreased reflexes) under dexmedetomidine, compared to propofol and alfaxalone. Time to induction was shortest with propofol, and time to recovery was shortest with dexmedetomidine. These agent-specific differences in urodynamic and anesthetic parameters in cats will facilitate appropriate study-specific anesthetic choices.

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Effects of anesthetics on cystometric parameters in female rats

Abstract: The results suggest that ether and midazolam are preferable to ketamine for anesthetized cystometry studies. The results were questionable for propofol, and further studies are needed to make it clear.

Cited by 16 publications

References 21 publications

Urodynamic characteristics of awake rats under retrained versus freely moving condition: Using a novel model

Urodynamic characteristics of awake rats under retrained versus freely moving condition: Using a novel model

Evaluation of the effects of sedation administered via three different routes on the procedure, child and parent satisfaction during cystometry

Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines

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