Effects of Anesthetic Agents on Hepatic Structure and Function in Dogs

Green, Henry D.; Ngai, S. H.; Sulak, Michael H.; Crow, John B.; Slocum, Harvey C.

doi:10.1097/00000542-195911000-00005

Cited by 10 publications

(1 citation statement)

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“…Halothanet has been shown repeatedly in man and in animals to have a benign effect upon the liver (Brindle, Gilbert and Millar, 1957;Burns et al, 1957;Carson et al, 1959;Gibson, 1959;Green et al, 1959;Hansen, Davis and Hardy, 1959;Johnstone, 1956;Krantz et al, 1958;Little, Barbour and Given, 1958;Morris, 1960;Quijani, 1958;Raventos, 1956;Virtue et al, 1958;Visser and Tarrow, 1959). Although Jones, Margolis and Stephen (1958) have produced massive fatty infiltration in mice following single intragastric administration and Stephen and his associates (1958) found centralobular fatty alteration following repeated inhalation in dogs, these changes were mild when compared with divinyl ether and chloroform.…”

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Effects of Halothane and Chloroform on the Liver in Protein-Deficient Mice

Wingard

Davis

Leonard

1965

British Journal of Anaesthesia

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A single 45-minute exposure to halothane did not cause demonstrable pathological liver changes when administered to mice in an atmosphere of air or oxygen regardless of whether the diet was normal or low in protein. Similarly, increased inhaled oxygen tensions per se had no influence on liver changes. The well-known hepatotoxicity of chloroform was demonstrated in groups fed both regular and low protein diets. The animals tolerated the single chloroform anaesthesia less well than those receiving halothane with significant liver damage in both groups.

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