Hepatic circulation and hepatic function during anaesthesia and surgery

Galindo, Alvaro

doi:10.1007/bf03004141

Cited by 19 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatic arterial vasodilatation in response to histamine has been observed previously (Galindo, 1965;Greenway & Stark, 1971). In the innervated liver histamine causes a dose-dependent increase in hepatic arterial bood flow of short duration.…”

Section: Discussionmentioning

confidence: 82%

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E₂, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG

Richardson

Withrington

1976

British J Pharmacology

View full text Add to dashboard Cite

1 The sympathetically-innervated arterial vascular bed of the dog's liver was perfused from a femoral artery. Arterial blood flow and perfusion pressure were measured continuously, and the hepatic arterial vascular resistance calculated. The preparation provided a means of assessing hepatic arterial vasodilatation quantitatively. 2 Isoprenaline, histamine, prostaglandin E2, glucagon and secretin were injected intra-arterially and all evoked dose-dependent vasodilatation of the hepatic arterial vascular bed. 3 The maximum reduction in the calculated hepatic arterial vascular resistance of 37-38% was the same for each of the five substances. 4 Comparisons on a weight basis revealed that prostaglandin E2 was the most potent, followed in potency order by secretin, isoprenaline, histamine and glucagon. 5Comparisons on a molar basis showed that secretin and prostaglandin E2 were intrinsically considerably more potent than isoprenaline, histamine or glucagon. 6 The onset of the vasodilatator responses to secretin, isoprenaline, histamine and prostaglandin E2 was rapid, and the duration of their actions was brief. 7 The onset of the vasodilator effects of glucagon was slow and its duration of action very prolonged. 8 The implications of these observations with respect to the physiological control of the hepatic arterial vascular bed of the dog are discussed.

show abstract

Section: Discussionmentioning

confidence: 82%

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E₂, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG

Richardson

Withrington

1976

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…15 Thiopental may produce a short-term depression of hepatic blood flow secondary to the initial change in cardiovascular performance after injection, 16 but unless the dose is inappropriately large, the total hepatic blood flow is essentially unaffected. The use of nitrous oxide 17 has not been shown to be associated with major changes in the splanchnic circulation.…”

Section: Hepatic Changes Associated With Anesthesiamentioning

confidence: 99%

A Review of Postoperative Liver Dysfunction

Davies

1983

Ann Saudi Med

View full text Add to dashboard Cite

“…TAKEUCHI, N. TERADA, and S. KOYAMA but the HAF shows ambiguous results: decreases (SELKURT and BRECHER, 1956;GALINDO, 1965;MUNDSCHAU et al, 1966) or increases (SANCETTA, 1953;GREENWAY et al, 1967b). Concerning the influence of reflexes on hepatic hemodynamics, occlusion of the carotid arteries in cats causes systemic arterial pressure (SAP) rise with little change in HAF (GREENWAY et al, 1967a), and carotid sinus hypotension in dogs increases the HAF and PVF (CARNEIRO and DONALD, 1977).…”

mentioning

confidence: 99%

Vasomotor center controls of the hepatic circulation during blood pressure oscillation in rabbits.

1986

View full text Add to dashboard Cite

Changes in hepatic hemodynamics during blood pressure oscillations caused by the side pressure exertion procedure (SPEP) were studied in anesthetized rabbits. The brain was excluded from systemic circulation except for one of the common carotids, which was compressed with stepwise elevated pressure. In normovolemia, the hepatic arterial flow (HAF) increased as the systemic arterial pressure (SAP) rose up to 140 mmHg, and then decreased as SAP rose further. With the rise of SAP, the portal venous flow (PVF) initially rose slightly, followed by a nearly constant decrease. Hemorrhaging influenced slightly the changes of HAF and PVF with the SAP rise. After volume loading, SAP and PVF markedly increased but HAF changed little. However, the initial increase in HAF with the SAP rise was markedly depressed by volume loading. PVF conspicuously decreased without initial increase with the rise in SAP. The hepatic vascular bed has a mechanism that prevents expected decrease of blood flow after hemorrhaging and during neurogenic hypertension. The interaction among HAF, PVF, and PVP may be involved in this mechanism.

show abstract

Hepatic circulation and hepatic function during anaesthesia and surgery

Cited by 19 publications

References 22 publications

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E₂, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E₂, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG

A Review of Postoperative Liver Dysfunction

Vasomotor center controls of the hepatic circulation during blood pressure oscillation in rabbits.

Contact Info

Product

Resources

About

Hepatic circulation and hepatic function during anaesthesia and surgery

Cited by 19 publications

References 22 publications

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E2, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E2, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG

A Review of Postoperative Liver Dysfunction

Vasomotor center controls of the hepatic circulation during blood pressure oscillation in rabbits.

Contact Info

Product

Resources

About

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E₂, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG

THE VASODILATOR ACTIONS OF ISOPRENALINE, HISTAMINE, PROSTAGLANDIN E₂, GLUCAGON AND SECRETIN ON THE HEPATIC ARTERIAL VASCULAR BED OF THE DOG