Effects of androgens on fertilizing capacity of human spermatozoa

Chan, Sandy; Tang, Lynn; Tang, Grace; Chan, PK

doi:10.1016/0010-7824(83)90079-3

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…As in these previous studies, our IHCA survivalto-discharge rate was lower than that reported in the GWTGR, which cites survival to discharge of 26.4% after non-COVID-related IHCA (18). Our ROSC percentage was also lower than that predicted by the GWTGR IHCA risk-standardization model in our 2020 cohort; however, the comorbidity burden in our patients exceeded that of those used to generate the model (22), perhaps partially explaining this discrepancy. In our 2021 cohort, our ROSC percentage exceeded that of the model.…”

Section: Discussioncontrasting

confidence: 61%

“…For comparison, the survival-to-discharge rate after CPR in 2018 at our medical center was 19.94% (unpublished data). Excluding those three patients with an unknown initial rhythm, the expected ROSC in this cohort based on the GWTGR IHCA risk-standardization model was 50.1% (22). Those who survived to 30 days post-IHCA were younger (46.3 vs 67.8; p = 0.03), but otherwise baseline characteristics were similar (Table 4).…”

Section: Spring 2020 Cohortmentioning

confidence: 99%

“…Of the 103 patients who received ACLS in the spring 2020 cohort, 35 (34.0%) had ROSC, and 15 (14.6%) were alive at 30 days (Table 3). Using the GWTGR across-hospital IHCA risk-standardization model (22), excluding those 11 patients with an unknown initial rhythm, the expected rate of ROSC in our cohort would have been 51.2% (47 patients). With respect to the 20 patients who did not survive to 30 days after ROSC, 12 (60.0%) had DNR orders placed after the first arrest.…”

Section: Spring 2020 Cohortmentioning

confidence: 99%

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In COVID-19 Patients Who Suffer In-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation Outcomes May Be Impacted by Arrest Etiology and Local Pandemic Conditions

Murphy

Nishikawa

Char

et al. 2022

Critical Care Explorations

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OBJECTIVES: The utility and risks to providers of performing cardiopulmonary resuscitation after in-hospital cardiac arrest in COVID-19 patients have been questioned. Additionally, there are discrepancies in reported COVID-19 in-hospital cardiac arrest survival rates. We describe outcomes after cardiopulmonary resuscitation for in-hospital cardiac arrest in two COVID-19 patient cohorts. DESIGN: Retrospective cohort study. SETTING: New York-Presbyterian Hospital/Columbia University Irving Medical Center in New York, NY. PATIENTS: Those admitted with COVID-19 between March 1, 2020, and May 31, 2020, as well as between March 1, 2021, and May 31, 2021, who received resuscitation after in-hospital cardiac arrest. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: Among 103 patients with coronavirus disease 2019 who were resuscitated after in-hospital cardiac arrest in spring 2020, most self-identified as Hispanic/Latino or African American, 35 (34.0%) had return of spontaneous circulation for at least 20 minutes, and 15 (14.6%) survived to 30 days post-arrest. Compared with nonsurvivors, 30-day survivors experienced in-hospital cardiac arrest later (day 22 vs day 7; p = 0.008) and were more likely to have had an acute respiratory event preceding in-hospital cardiac arrest (93.3% vs 27.3%; p < 0.001). Among 30-day survivors, 11 (73.3%) survived to hospital discharge, at which point 8 (72.7%) had Cerebral Performance Category scores of 1 or 2. Among 26 COVID-19 patients resuscitated after in-hospital cardiac arrest in spring 2021, 15 (57.7%) had return of spontaneous circulation for at least 20 minutes, 3 (11.5%) survived to 30 days post in-hospital cardiac arrest, and 2 (7.7%) survived to hospital discharge, both with Cerebral Performance Category scores of 2 or less. Those who survived to 30 days post in-hospital cardiac arrest were younger (46.3 vs 67.8; p = 0.03), but otherwise there were no significant differences between groups. CONCLUSIONS: Patients with COVID-19 who received cardiopulmonary resuscitation after in-hospital cardiac arrest had low survival rates. Our findings additionally show return of spontaneous circulation rates in these patients may be impacted by hospital strain and that patients with in-hospital cardiac arrest preceded by acute respiratory events might be more likely to survive to 30 days, suggesting Advanced Cardiac Life Support efforts may be more successful in this subpopulation.

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Section: Discussioncontrasting

confidence: 61%

Section: Spring 2020 Cohortmentioning

confidence: 99%

Section: Spring 2020 Cohortmentioning

confidence: 99%

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In COVID-19 Patients Who Suffer In-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation Outcomes May Be Impacted by Arrest Etiology and Local Pandemic Conditions

Murphy

Nishikawa

Char

et al. 2022

Critical Care Explorations

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“…T (testosterone) and DHT (dihydrotestosterone) were both capable to inhibit the fertilizing capacity of human sperm inhibiting the penetration of zona-free hamster ova in vitro. This effect appeared not to be related to sperm motility [11]. Recent study showed that local excess of androgens inhibits phosphoinositide 3-kinase (PI3K) activity and affects negatively with human sperm survival [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Steroid Receptors mRNA Fingerprints in Two Groups of Normozoospermic Patients: Men from Unexplained Infertility Couples vs. Men from Couples with Tubal Factor Infertility

Jarząbek¹,

Mikucka-Niczyporuk²,

Bielawski³

et al. 2017

OJOG

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The study of sperm cellular components at molecular level is crucial for the diagnosis of male unexplained infertility. The aim of the study was to compare the molecular profile of steroid receptors and aromatase in spermatozoa obtained from two normozoospermic groups of patients issued from couples treated for infertility. We investigated 46 male patients from unexplained infertility couples and from men, 38 where female partners presented with tubal infertility. Sperm ERs (estrogen receptors: alpha and beta), GPER (G proteincoupled estrogen receptor), AR (androgen receptor) and aromatase mRNA expression levels by TaqMan qPCR were analyzed. AR transcript level was significantly lower in sperm of men from unexplained infertility couples vs. men from couples with tubal factor infertility (P = 0.04). Although the AR mRNA expression level did not had any effect on embryo development and its implantation, a significant correlation between AR mRNA levels and clinical pregnancy in unexplained infertility patients was observed. Taken together, AR transcript presence in ejaculated spermatozoa could be a potential marker for unexplained infertility.

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Taurine and human spermatozoal capacitation

Chan

1985

Cell Biology International Reports

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The effect of taurine at various concentrations (0.01, 0.1 and 1 mM) on the in vitro motility and fertilizing capacity of human spermatozoa was studied. Spermatozoa collected from 10 normal men were washed in BWW medium and incubated with taurine for 5 hours, the period required for spermatozoal capacitation. The percent motilities were recorded at 0 and 5 hours during capacitation preincubation with taurine. After incubation, the spermatozoa were washed with BWW medium to remove taurine before insemination of the zona-free hamster ova for an assessment of the fertilizing capacity. Taurine caused a significant dose-dependent increase in the penetration of the zona-free hamster ova in comparison to the control (p less than 0.05). Taurine did not have any significant effects on the spermatozoal motility during capacitation preincubation. The results suggest that there may be a physiological role for this beta-amino acid in human spermatozoal capacitation in vivo.

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Effects of androgens on fertilizing capacity of human spermatozoa

Cited by 12 publications

References 22 publications

In COVID-19 Patients Who Suffer In-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation Outcomes May Be Impacted by Arrest Etiology and Local Pandemic Conditions

In COVID-19 Patients Who Suffer In-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation Outcomes May Be Impacted by Arrest Etiology and Local Pandemic Conditions

Evaluation of Steroid Receptors mRNA Fingerprints in Two Groups of Normozoospermic Patients: Men from Unexplained Infertility Couples vs. Men from Couples with Tubal Factor Infertility

Taurine and human spermatozoal capacitation

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