Effects of Androgenic Sterols in Hypophysectomized and in Castrated Rats

Cutuly, Eugene; McCullagh, D. Roy; Cutuly, Elizabeth C.

doi:10.1152/ajplegacy.1938.121.3.786

Cited by 13 publications

(2 citation statements)

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“…Lately, however, evidence has been obtained that the male hormones, when injected into hypophysectomized rats, produce a better development of generative tissue of testes and stimulation of spermatogenesis instead of a depressing effect (Cutuly, McCullagh, and Cutuly, 1938;Hamilton and Leonard, 1938). Even without hypophysectomy, stimulation of the testes by male hormones can be produced in certain animalsfor example, ground squirrels (Wells and Moore, 1936).…”

Section: Effect Of Injections On the Testesmentioning

confidence: 99%

Prolonged Injections of Male Sex Hormones

Korenchevsky¹,

Hall²

1939

BMJ

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Section: Effect Of Injections On the Testesmentioning

confidence: 99%

Prolonged Injections of Male Sex Hormones

Korenchevsky¹,

Hall²

1939

BMJ

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“…The results shown in Table 4 (Cutuly, McCullagh & Cutuly, 1937, 1938, or in response to the administration of antigonadotrophic agents, such as oestrogens (Ludwig, 1950), is prevented by the administration of testosterone. It is evident from the data shown in Table 3 that testosterone prevented the reduction in testis weight induced with norethindrone, a known antigonado¬ trophic steroid which reduces gonadal weight and blocks ovulation (Drill, 1966;Boris, Trmal & Nelson, 1972) The results obtained with testosterone and gonadotrophin administration in rats treated with PMHI and the data in hypophysectomized animals suggested that an involvement of the pituitary-gonadal axis in the mechanisms of action of PMHI was highly unlikely.…”

Section: As Shown Inmentioning

confidence: 98%

Further Studies on the Antitesticular Activity of a Pipecolinomethylhydroxyindane

Boris¹,

DeMARTINO²,

Cox³

1974

Reproduction

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Summary. Treatment with dl-6-(N-\g=a\-pipecolinomethyl)-5-hydroxyindane maleate (PMHI) depressed testis weights in immature rats, mice, hamsters and guinea-pigs. Similar effects on testicular weight were observed in adult rabbits, dogs and two species of monkey. Concurrent administration of testosterone, gonadotrophins, dl-tocopherol acetate, and methionine did not prevent the testicular weight reduction induced with PMHI in the immature rat. In hypophysectomized rats, the administration of PMHI caused further significant reduction in testicular weights. These data indicate that the activity of PMHI is directly on the testis and is not mediated by way of the hypothalamus\p=m-\pituitary\p=m-\ gonadal axis.

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Local maintenance of spermatogenesis by intratesticularly implanted pellets of testosterone in hypophysectomized rats

Dvoskin

1944

Am. J. Anat.

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The maintenance of spermatogenesis in hypophysectomized rats by means of the injection of androgen in oil was first reported by Wdsh, Cuyler and McCullagh in 1934. I n these experiments, spermatogenesis was maintained for 20 days by the daily injection of an extract of male urine. This finding was confirmed by Nelson and Gallagher ('36) who extended the period of maintenance to 39 days. Nelson ('3'7) obtained maintenance for 60 days, and later ('40) for 178 days. The animals sired litters during the latter part of the period of treatment. From control experiments in which it was found that fertility persisted in androgen-treated hypophysectoinized animals longer than did motility of sperm in androgen-treated castrates, Nelson ( '37) demonstrated that the androgen injections caused a true maintenance of spermatogenesis, not merely the prolongation of the life of the sperm which were present at the time of hypophysectomy.The injection of a large number of synthetic androgens which have not been found to occur in nature, as well as crystal-Foundation. of Philosophy, in the Faculty of Pure Science, Columbia University. 'Aided by a grant, administered by Dr. P. E. Smith, from the Rockefeller * Submitted in partial fulfillment of the requirements for the degree of Doctor TABLr; 1-Absolute and relative weights of ventral prostates and seminal vesicles of hypophysectomiaed (Hypx.), crnoperated normal and castrute rats. One group of hypophysoctomi2ed rats was untreated; the others, at the t h e the hypophysis was ablated, received implants of pellets which contained various percentages of testosterone. Autopsie8 were performed 20 days later except for the last two groups which were autopsied after 40 days. Relative Hypx.contr. = 11.00

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Effects of Androgenic Sterols in Hypophysectomized and in Castrated Rats

Cited by 13 publications

References 0 publications

Prolonged Injections of Male Sex Hormones

Prolonged Injections of Male Sex Hormones

Further Studies on the Antitesticular Activity of a Pipecolinomethylhydroxyindane

Local maintenance of spermatogenesis by intratesticularly implanted pellets of testosterone in hypophysectomized rats

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