Background: Osteoporosis is one of the most common bone metabolic disorders which have been associated with significant disability and mortality. Osteoporosis has been recognized as a major public health problem by nurses' providers in Egypt. Therefore, this study aims to compare between nurses' health beliefs and their Preventive Measures regarding osteoporosis in Egypt and Sudan. Method: A descriptive research design was used in the current study. Setting: The study was conducted in internal medicine and orthopedic units and medical and orthopedic out patients' clinic at three hospitals affiliated to the Ministry of Health named Port-Said General Hospital, Port-Fouad General Hospital, and El-Zohor central Hospital. In addition to outpatient Clinics (MCH center) at Khartoum, Bihari and Omdurman in Sudan country. Sample; A convenient sample used for this research which consists of all nurses working in the previous mentioned settings, total number of 170 nurse, distributed as the following; 90 from Egypt and 80 from Sudan from different hospital specialties were included in the study. Tool; questionnaire about preventive measures regarding osteoporosis and osteoporosis health beliefs scale (OHBS) were used for collecting data of the current study. Results; the study results revealed significant differences between Egypt and Sudan regarding some subscales of health beliefs regarding osteoporosis as susceptibility, seriousness, barrier of calcium intake and health motivation with P-value of 0.027, 0.013,059 and 0.024 respectively. However, there were no significant differences between both countries regarding nurse action to prevent osteoporosis. Conclusion: there were no significant differences between Egypt and Sudan regarding preventive measures applied by nurses to prevent osteoporosis in spite of the significant differences between both countries regarding health beliefs about osteoporosis. Recommendations: An educational program for the nurses to raise their awareness regarding causes, prevention & early detection and proper treatment of osteoporosis. Additionally, the nursing college curriculum committee should be focus on osteoporosis management.