Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis

Johnson, Kenneth A.; Hulse, Donald A.; Hart, R. C.; Kochevar, Deborah T.; Chu, Qili

doi:10.1053/joca.2000.0345

Cited by 65 publications

(56 citation statements)

References 40 publications

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“…It has been suggested to restore the extracellular matrix of cartilage, reducing degradation in OA, and provide sulphur-containing amino acids that are essential for the cartilage extra-cellular matrix, which may be deficient from regular diets [24,25]. A systematic review of chondroitin found that chondroitin had small to moderate effects on pain and physical function in patients with OA, which were clinically significant [26].…”

Section: Chondroitinmentioning

confidence: 99%

Modern Non-Pharmacological and Non-Surgical Treatments for Hip Pain

Lee¹,

Rozewicz²,

Chandrappa³

et al. 2018

J Arthritis

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Osteoarthritis of the hip describes a clinical syndrome of joint pain accompanied by varying degrees of functional limitation and reduced quality of life. Osteoarthritis may not be progressive and most patients will not need surgery, with their symptoms adequately controlled by non-surgical measures. The treatment of hip osteoarthritis is aimed at reducing pain and stiffness and improving joint mobility. Total hip replacement remains the most effective treatment option but it is a major surgery with potential serious complications. NICE guideline has suggested a holistic approach to management of hip osteoarthritis which includes both nonpharmacological and pharmacological treatments. The non-pharmacological treatments range from education ,physical therapy and behavioral changes ,walking aids .The ESCAPE( Enabling Self-Management and Coping of Arthritic Pain Through Exercise) rehabilitation programme for hip and knee osteoarthritis which integrates simple education, self-management and coping strategies, with an exercise regimen has shown to be more cost-effective than usual care. There is a choice of reviewed pharmacological treatments available, but there are few current reviews of possible nonpharmacological methods. This review will focus on the non-pharmacological and non-surgical methods.

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Section: Chondroitinmentioning

confidence: 99%

Modern Non-Pharmacological and Non-Surgical Treatments for Hip Pain

Lee¹,

Rozewicz²,

Chandrappa³

et al. 2018

J Arthritis

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“…A negative-controlled study conducted by Johnson and others (2001) tested the effects of a supplement containing 200 mg CS, 250 mg GH, and 5 mg manganese ascorbate per capsule in dogs who underwent cranial cruciate ligament transection (n = 16). Dogs were given 3 capsules every 12 hours for 30 days before the dose was reduced to 2 capsules every 12 hours for the following 4 months (Johnson et al, 2001). Compared to the controls, dogs given the supplement had elevated concentrations of CS epitopes in synovial fluid, suggesting modulation of articular cartilage matrix metabolism (Johnson et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Dogs were given 3 capsules every 12 hours for 30 days before the dose was reduced to 2 capsules every 12 hours for the following 4 months (Johnson et al, 2001). Compared to the controls, dogs given the supplement had elevated concentrations of CS epitopes in synovial fluid, suggesting modulation of articular cartilage matrix metabolism (Johnson et al, 2001). A doubleblind, placebo-controlled study conducted using arthritic dogs (n = 7 to 10/treatment group) noted a reduction in observational pain overall (51%), after limb manipulation (48%), and after physical exertion (43%) after 150 days of supplementation of 2000 mg GH and 1600 mg CS (P < 0.05) (Gupta et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…It is also known to reduce the concentration of pro-inflammatory cytokines (Bottegoni et al, 2014). The use of CS and glucosamine together have been shown to work additively to help decrease the advancement of OA by favoring matrix synthesis and repairing articular cartilage (Clegg et al, 2006;Johnson et al, 2001).…”

Section: Common Nutraceuticals Glucosamine and Chondroitinmentioning

confidence: 99%

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Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis

Price¹,

Godoy²,

Harper³

et al. 2017

Journal of Animal Science

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Symptoms of osteoarthritis (OA) afflict approximately 20% of adult dogs in NorthAmerica. Clinical signs consistent with OA include decreased range of motion of a joint, reduced physical activity, difficulty climbing stairs or onto furniture, and a reduced ability to rise from a lying position. A safe and effective nutraceutical supplement may benefit dogs suffering from OA. Calcium fructoborate (CFB), a mimetic of a naturally occurring molecule, has previously been reported to be safe and effective in humans with joint problems. The objective of this randomized, double-blinded, placebo-controlled study was to evaluate the short-term effects of CFB alone, or in combination with a blend of glucosamine hydrochloride (GH) and chondroitin sulfate (CS), on gait analysis, goniometry, serum inflammatory markers, and owner perception of pain in client-owned dogs. Sixty-four dogs with joint discomfort were recruited and 59 dogs (mean age = 8.42 ± 0.37 yr.; mean BW = 31.11 ± 1.28 kg) completed the study. All procedures were approved by the University of Illinois Institutional Animal Care and Use Committee, and pet owners signed an informed consent prior to study initiation. Dogs were randomly assigned to one of four treatments: placebo (60 mg fructose; n = 15), low dose (69 mg CFB; n = 14), high dose (127 mg CFB; n = 14), or combination (69 mg CFB, 500 mg GH and 200 mg CS; n = 16).Treatments were provided once daily as dietary supplements. Small dogs weighing up to 22.9 kg received 1 capsule/day, while large dogs weighing 23 to 50 kg received 2 capsules/day for 28 days. A physical examination, radiographs, goniometry measurements, gait analysis, blood sample collection, and the canine brief pain inventory (CBPI) questionnaire were performed and administered on days 0 and 28. As expected, a majority (69%) of the dogs were overweight or obese, with a body condition score (BCS) > 6 on a 9-point scale. Dogs fed the low dose (-2.93) and high dose (-2.21) of CFB were shown to improve (P < 0.05) in their ability to rise from a iii lying position from day 0 to day 28 compared to dogs fed the placebo (0.00), but no difference was observed for dogs fed the combination treatment. Dogs assigned the low dose of CFB also tended to have an improved pain severity score (PSS; -1.46; P = 0.08) and pain at its worst score (-2.14; P = 0.06) from day 0 to day 28 compared to dogs fed the placebo (0.05 and 0.00, respectively). Dogs fed the high dose of CFB had a greater increase (P = 0.05) in serum concentration of soluble receptor for advanced glycation end products (sRAGE) from day 0 to day 28 (7.88 ng/mL) compared to dogs fed the placebo (0.83 ng/mL). All blood metabolites were within reference range except total alkaline phosphatase and corticosteroid-induced alkaline phosphatase, which started and ended at concentrations greater than the upper reference range.Dogs assigned the high dose of CFB tended to have a greater reduction (P = 0.07) in serum chloride from day 0 to day 28 (-1.64 mmol/L) compared to dogs fed the low dose of ...

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“…Osteoarthritis is a slowly progressive, degenerative, and debilitating disease affecting 20% of the canine population over the age of one (Johnston, 1997;Johnson et al, 2001;Roush et al, 2002;Aragon et al, 2007). Large-breed dogs may develop more severe clinical signs and initial symptoms of osteoarthritis; however, dogs of all sizes and breeds are affected by the disease as they age (Rychel, 2010).…”

Section: Introductionmentioning

confidence: 99%

Glucosamine and chondroitin use in canines for osteoarthritis: A review

Bhathal¹,

Spryszak²,

Louizos³

et al. 2017

Open Vet J.

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Osteoarthritis is a slowly progressive and debilitating disease that affects canines of all breeds. Pain and decreased mobility resulting from osteoarthritis often have a negative impact on the affected canine's quality of life, level of comfort, daily functioning, activity, behaviour, and client-pet companionship. Despite limited and conflicting evidence, the natural products glucosamine hydrochloride (HCl) and chondroitin sulfate are commonly recommended by veterinarians for treating osteoarthritis in dogs. There is a paucity of well-designed clinical veterinary studies investigating the true treatment effect of glucosamine and chondroitin. The purposes of this review article are to provide a brief background on glucosamine and chondroitin use in canine osteoarthritis and to critically review the available literature on the role of these products for improving clinical outcomes. Based on critical review, recommendations for practice are suggested and a future study design is proposed.

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Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis

Abstract: Administration of CS-G-M was associated with altered concentrations of 3B3 and 7D4 epitope in synovial fluid, suggesting that these compounds may act to modulate articular cartilage matrix metabolism in vivo.

Cited by 65 publications

References 40 publications

Modern Non-Pharmacological and Non-Surgical Treatments for Hip Pain

Modern Non-Pharmacological and Non-Surgical Treatments for Hip Pain

Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis

Glucosamine and chondroitin use in canines for osteoarthritis: A review

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