Effects of an Exercise Program in Colon Cancer Patients undergoing Chemotherapy

Vulpen, Jonna K. van; Velthuis, Miranda J.; Bisschop, Charlotte N. Steins; Travier, Noémie; Buijs, Bram J W van den; Backx, Frank; Los, Maartje; Erdkamp, Frans; Bloemendal, Haiko J.; Koopman, Miriam; Roos, Marnix A.J. de; Verhaar, Marlies; Bokkel-Huinink, Daan ten; Wall, Elsken van der; Peeters, Petra H.; May, Anne M.

doi:10.1249/mss.0000000000000855

Cited by 108 publications

(160 citation statements)

References 33 publications

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“…15 More details of the programme have been described elsewhere. [12][13][14] Control group Participants randomised to control received usual care and were asked to maintain their habitual physical activity pattern up to week 18. Thereafter, participants were allowed, for ethical reasons, to participate in exercise programmes offered routinely after cancer treatment.…”

Section: Exercise Interventionmentioning

confidence: 99%

Cost-effectiveness analysis of an 18-week exercise programme for patients with breast and colon cancer undergoing adjuvant chemotherapy: the randomised PACT study

et al. 2017

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ObjectiveMeta-analyses show that exercise interventions during cancer treatment reduce cancer-related fatigue. However, little is known about the cost-effectiveness of such interventions. Here we aim to assess the cost-effectiveness of the 18-week physical activity during cancer treatment (PACT) intervention for patients with breast and colon cancer. The PACT trial showed beneficial effects for fatigue and physical fitness.DesignCost-effectiveness analyses with a 9-month time horizon (18 weeks of intervention and 18 weeks of follow-up) within the randomised controlled multicentre PACT study.SettingOutpatient clinics of 7 hospitals in the Netherlands (1 academic and 6 general hospitals)Participants204 patients with breast cancer and 33 with colon cancer undergoing adjuvant treatment including chemotherapy.InterventionSupervised 1-hour aerobic and resistance exercise (twice per week for 18 weeks) or usual care.Main outcome measuresCosts, quality-adjusted life years (QALY) and the incremental cost-effectiveness ratio.ResultsFor colon cancer, the cost-effectiveness analysis showed beneficial effects of the exercise intervention with incremental costs savings of €4321 and QALY improvements of 0.03. 100% of bootstrap simulations indicated that the intervention is dominant (ie, cheaper and more effective). For breast cancer, the results did not indicate that the exercise intervention was cost-effective. Incremental costs were €2912, and the incremental effect was 0.01 QALY. At a Dutch threshold value of €20 000 per QALY, the probability that the intervention is cost-effective was 2%.ConclusionsOur results suggest that the 18-week exercise programme was cost-effective for colon cancer, but not for breast cancer.Trial registration numberISRCTN43801571.

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Section: Exercise Interventionmentioning

confidence: 99%

Cost-effectiveness analysis of an 18-week exercise programme for patients with breast and colon cancer undergoing adjuvant chemotherapy: the randomised PACT study

et al. 2017

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“…O processo da análise dos estudos está ilustrado na Figura 1 por meio do fluxograma PRISMA (22) . (28) Ensaio Clínico Randomizado…”

Section: Métodounclassified

Intervenções No Manejo Da Fadiga E Qualidade De Vida Em Pacientes Em Quimioterapia: Estudo De Revisão

Mendes¹,

Barichello

2019

Cogitare Enferm.

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Objetivo: identificar na literatura as intervenções não farmacológicas utilizadas no manejo da fadigaoncológica e Qualidade de vida de pacientes com neoplasia digestiva em quimioterapia.Método: trata-se de uma revisão integrativa. Foram utilizadas as bases de dados MEDLINE,Pubmed, Scopus, CINAHL e Web of Science. Foram selecionados artigos em português, inglês eespanhol entre 2013-2018, que descreviam o uso de intervenções não farmacológicas utilizadas nafadiga oncológica e/ou Qualidade de Vida de pacientes com neoplasia digestiva em quimioterapia.Resultados: do total de 278 artigos, seis foram selecionados. Em relação ao idioma, todos estavamem inglês. Entre os ensaios clínicos, somente um pontuou cinco na Escala de Qualidade de Jadad.Os estudos trouxeram a utilização de programas de atividade física como sendo eficazes.Conclusão: a prática de atividades física foi considerada uma intervenção eficaz, já a acupunturanão apresentou resposta clínica viável no manejo da fadiga oncológica e Qualidade de Vida.

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“…In the ‘Physical Activity during Cancer Treatment' (PACT) trial recently conducted in the Netherlands, colon cancer patients undergoing chemotherapy were randomly assigned to either a group receiving a supervised exercise program or to ‘usual care' without intervention. The patients in the exercise group experienced significantly less physical fatigue and reported higher levels of physical functioning compared to patients in the ‘usual care' group [11]. Therefore, adding a program of moderate PA to best supportive care during this phase could significantly improve QOL and contribute to the wellbeing of the patients.…”

Section: Colorectal Cancer and Physical Activitymentioning

confidence: 99%

Physical Activity and Nutrition in Primary and Tertiary Prevention of Colorectal Cancer

Schoenberg¹

2016

Visc Med

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Background: Lifestyle factors play a pivotal role in the primary and tertiary prevention of colorectal cancer. The purpose of this review article is to summarize data concerning the effect of the lifestyle factors physical activity (PA) and nutrition in primary and, more importantly, tertiary prevention of colorectal cancer (CRC). Methods: Focusing on the influence of lifestyle factors on prognosis und quality of life (QOL), a comprehensive literature search of clinical studies published mainly in the years 2000 until 2015 was performed and the current knowledge based on these clinical studies reviewed. Results: Besides avoiding risk factors (such as smoking and overindulgence in alcohol), healthy weight, regular and moderate PA as well as a diet which contains fruit, vegetables, poultry, and fish (so-called ‘Mediterranean' diet) may reduce the risk of the disease significantly. Patients already diagnosed with CRC can also actively improve the prognosis of CRC and QOL by changing their lifestyle. Patients commencing moderate exercise and modifying their eating habits in terms of a ‘Mediterranean' diet can reduce cancer-specific and overall mortality by up to 40% and significantly increase their quality of life already during chemotherapy. Therefore, moderate physical exercise, calorie restriction, and a Mediterranean dietary pattern for patients with CRC should be recommended by physicians treating these patients. In fact, the World Cancer Research Fund/American Institute for Cancer Research (AICR/WCRF) systematic literature review from 2007 shows that the lifestyle changes recommended after diagnosis are the same for primary prevention of this disease. Conclusion: Lifestyle changes such as moderate PA and a Mediterranean diet significantly improve the QOL as well as the prognosis of patients suffering from colorectal disease. However, the effect of lifestyle changes is mostly based on observational studies, while only few studies are prospective and none are randomized. Therefore, these observational studies warrant controlled randomized trials to prove the effectiveness of lifestyle interventions on QOL and cancer recurrence.

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Effects of an Exercise Program in Colon Cancer Patients undergoing Chemotherapy

Cited by 108 publications

References 33 publications

Cost-effectiveness analysis of an 18-week exercise programme for patients with breast and colon cancer undergoing adjuvant chemotherapy: the randomised PACT study

Cost-effectiveness analysis of an 18-week exercise programme for patients with breast and colon cancer undergoing adjuvant chemotherapy: the randomised PACT study

Intervenções No Manejo Da Fadiga E Qualidade De Vida Em Pacientes Em Quimioterapia: Estudo De Revisão

Physical Activity and Nutrition in Primary and Tertiary Prevention of Colorectal Cancer

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