Effects of an Ascorbic Acid–Derivative Dentifrice in Patients With Gingivitis: A Double‐Masked, Randomized, Controlled Clinical Trial

Shimabukuro, Yoshio; Nakayama, Yohei; Ogata, Yorimasa; Tamazawa, Kaoru; Shimauchi, Hidetoshi; Nishida, Toshirou; Ito, Koichi; Chikazawa, Takashi; Kataoka, Shinsuke; Murakami, Shinya

doi:10.1902/jop.2014.140138

Cited by 25 publications

(27 citation statements)

References 34 publications

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“…Shimabukuro et al . found that APM administered in a dentifrice reduced the gingival index in a double‐masked, randomized, controlled clinical trial. Our investigations suggest that APM possesses a mechanism that improves gingivitis by maintaining the barrier function.…”

Section: Discussionmentioning

confidence: 96%

Decreased expression of E‐cadherin by Porphyromonas gingivalis‐lipopolysaccharide attenuates epithelial barrier function

Abe-Yutori

Chikazawa

Shibasaki

et al. 2016

J of Periodontal Research

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These results suggest that the decrease in E-cad caused by P. gingivalis-LPS leads to destruction of the epithelial barrier function in human gingival epithelial cells, and finally accelerates the inflammatory reaction under the barrier. Antioxidants, particularly vitamin E and l-ascorbic acid 2-phosphate magnesium salt, may restore the impaired function by scavenging ROS, which are related to the decrease in E-cad expression by P. gingivalis-LPS.

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Section: Discussionmentioning

confidence: 96%

Decreased expression of E‐cadherin by Porphyromonas gingivalis‐lipopolysaccharide attenuates epithelial barrier function

Abe-Yutori

Chikazawa

Shibasaki

et al. 2016

J of Periodontal Research

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“…APM is broadly used in cosmetics. A double-masked, randomized, controlled clinical trial has shown that the regular application of an APM-containing dentifrice could reduce gingival inflammation [35]. Collectively, low-dose prolonged exposure to vitamin C, especially APM, may be effective in the treatment of kidney cancers, and low doses may be as effective as or more effective than high doses.…”

Section: Discussionmentioning

confidence: 99%

Restoration of 5‐hydroxymethylcytosine by ascorbate blocks kidney tumour growth

Ding

et al. 2018

EMBO Reports

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Loss of 5-hydroxymethylcytosine (5hmC) occurs frequently in a wide variety of tumours, including clear-cell renal cell carcinoma (ccRCC). It remains unknown, however, whether the restoration of 5hmC patterns in tumours could have therapeutic efficacy. Here, we used sodium L-ascorbate (vitamin C, AsANa) and the oxidation-resistant form L-ascorbic acid 2-phosphate sesquimagnesium (APM) for the restoration of 5hmC patterns in ccRCC cells. At physiological concentrations, both show anti-tumour efficacy during long-term treatment Strikingly, global 5hmC patterns in ccRCC cells after treatment resemble those of normal kidney tissue, which is observed also in treated xenograft tumours, and in primary cells from a ccRCC patient. Further, RNA-seq data show that long-term treatment with vitamin C changes the transcriptome of ccRCC cells. Finally, APM treatment induces less non-specific cell damage and shows increased stability in mouse plasma compared to AsANa. Taken together, our study provides proof of concept for an epigenetic differentiation therapy of ccRCC with vitamin C, especially APM, at low doses by 5hmC reprogramming.

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“…The local injection of vit-C was preferred rather than the usage of topical vitamin C gel or dentifrice that was previously used by Daniels and Jefferies [22] and Shimabukuro et al [23]. Vitamin C is a water-soluble agent that has superficial penetrating effect.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study

Yussif

Aziz

Rahman

2016

Journal of Nutrition and Metabolism

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Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the treatment of persistent gingival inflammation. Design. Twenty adult patients with persistent chronic gingival inflammation were included in this study. The same dose of sterile vitamin C was injected in gingival tissues after the completion of phase I therapy. Gingival biopsies were taken after total resolution of inflammation. The specimens were examined histologically, using H&E stain. Results. Clinical evaluation revealed great improvement of the injected sites with recall visits. Histopathological results revealed marked decrease in inflammatory cells and epithelial thickness and a higher number of newly formed subbasal capillaries. Conclusions. Vitamin C is an effective adjunctive treatment in reducing various degrees of chronic gingival inflammation.

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Effects of an Ascorbic Acid–Derivative Dentifrice in Patients With Gingivitis: A Double‐Masked, Randomized, Controlled Clinical Trial

Abstract: These findings indicate that the regular application of an APM-containing dentifrice could reduce gingival inflammation.

Cited by 25 publications

References 34 publications

Decreased expression of E‐cadherin by Porphyromonas gingivalis‐lipopolysaccharide attenuates epithelial barrier function

Decreased expression of E‐cadherin by Porphyromonas gingivalis‐lipopolysaccharide attenuates epithelial barrier function

Restoration of 5‐hydroxymethylcytosine by ascorbate blocks kidney tumour growth

Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study

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