Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise

Kanter, M. M.; Nolte, Lorraine A.; Holloszy, John O.

doi:10.1152/jappl.1993.74.2.965

Cited by 264 publications

(165 citation statements)

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“…The correlation was calculated for the changes in the plasma values of AST and CPK after the 50-and 80-km marches (R 2 50 ϭ 0.888; R 2 80 ϭ 0.814). inhibits the propagation of lipid-peroxidation chain reactions in cellular membranes (42) and helps to regenerate vitamin E from the ␣-tocopheryl radical (43,44). It was therefore anticipated that the AA level would decline during and after the marches, as was reported in some studies (45,46).…”

Section: Figmentioning

confidence: 92%

Plasma antioxidant status and cell injury after severe physical exercise

Chevion

Moran

Heled

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

211

134

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Strenuous exercise leads to an increase in metabolic rate, increased production of reactive oxygen species, and compromised antioxidant defense systems. To study the effects of oxidative stress during strenuous exercise, a homogeneous group of 31 male subjects participated in a 6-month, 5 days͞week training schedule involving two extreme marches of 50 km and 80 km at sea level, separated by 2 weeks of regular training. Each participant carried 35 kg of extra weight. Blood samples were drawn imediately before and after each march. Twenty-nine subjects completed the 50-km march, and only 16 completed the 80-km march. Plasma levels of reduced ascorbic acid, total ascorbate, and dehydroascorbate did not undergo significant changes during either march. However, the 50-and 80-km marches led to 25% and 37% increases, respectively, in plasma levels of uric acid; due presumably to increases in the metabolic rate and consequent pyrimidine nucleotide metabolism. Both marches led to Ϸ10-fold increase leakage of creatine phosphokinase into the plasma. Likewise, plasma levels of aspartate transaminase, a characteristic marker of liver injury, increased Ϸ4-fold. Plasma levels of bilirubin, creatine, urea, and glucose also increased. Plasma protein carbonyl content, a marker of protein oxidative damage, decreased significantly during each march. These results are discussed with respect to the consideration that elevation of the respiration rate during exercise leads to production of more reactive oxygen species than the antioxidant systems can scavenge. Plausible explanations for leakage of molecules into the plasma are discussed.

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Section: Figmentioning

confidence: 92%

Plasma antioxidant status and cell injury after severe physical exercise

Chevion

Moran

Heled

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

211

134

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“…Durante el ejercicio, el músculo y el organismo en general se ven sometidos a un gran estrés oxidativo, es decir, hay una pérdida del equilibrio entre la producción de radicales libres y especies reactivas de oxígeno, Acoplamiento excitación-contracción y la capacidad de las células para manejarlos (121)(122)(123)(124). El aumento de los radicales libres parece alterar la liberación de Ca 2+ desde el retículo sarcoplásmico, aunque el efecto sobre la fatiga muscular no está claro (125)(126)(127), además de disminuir la sensibilidad de la miofibrilla al Ca 2+ en mamíferos (128,129).…”

Section: El Aumento Del Mg 2+unclassified

El acoplamiento excitación-contracción en el músculo esquelético: preguntas por responder a pesar de 50 años de estudio

Calderón-Vélez

Figueroa

2009

biomedica

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El mecanismo de acoplamiento excitación-contracción fue definido en el músculo esquelético como la secuencia de eventos que ocurre desde la generación del potencial de acción en la fibra muscular hasta que se inicia la generación de tensión. La regulación e interacción de dichos eventos entre sí ha sido estudiada durante los últimos 50 años utilizando diferentes técnicas, con las cuales se estableció la importancia y origen del ion calcio como activador contráctil, se conocen las principales proteínas involucradas y se inició el estudio de la base ultraestructural y de la regulación farmacológica; además, hay evidencias de que el acoplamiento excitación-contracción se altera en diferentes situaciones como en el envejecimiento, en la fatiga muscular y en algunas enfermedades musculares. Sin embargo, aún hay varias preguntas por responder: ¿cómo es el desarrollo y envejecimiento del mecanismo de acoplamiento excitación-contracción?, ¿cuál es su papel en la fatiga muscular y en algunas enfermedades musculares?, ¿cuál es la naturaleza de la interacción entre diferentes proteínas involucradas en el acoplamiento excitación-contracción? La presente revisión describe el acoplamiento excitación-contracción en el músculo esquelético y las técnicas utilizadas para su estudio como introducción para discutir algunas de las preguntas que aún falta por responder al respecto.Palabras clave: músculo esquelético, contracción muscular, relajación muscular, calcio, canal liberador de calcio, canales de calcio tipo L, receptor de rianodina, fatiga muscular. Excitation-contraction coupling in skeletal muscle: questions remaining after 50 years of researchThe excitation-contraction coupling mechanism was defined as the entire sequence of reactions linking excitation of plasma membrane to activation of contraction in skeletal muscle. By using different techniques, their regulation and interactions have been studied during the last 50 years, defining until now the importance and origin of the calcium ion as a contractile activator and the main proteins involved in the whole mechanism. Furthermore, the study of the ultrastructural basis and pharmacological regulation of the excitation-contraction coupling phenomenon has begun. The excitation-contraction coupling is thought to be altered in situations as ageing, muscle fatigue and some muscle diseases. However, many questions remain to be answered. For example, (1) How excitation-contraction coupling develops and ages? (2) What role does it play in muscle fatigue and other diseases? (3) What is the nature of the interaction between the proteins believed to be involved? The present review describes excitation-contraction coupling in skeletal muscle and techniques used to better understand it as an introduction for discussing unanswered questions regarding excitation-contraction coupling.

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“…Kanter et al (28) show that daily supplementation with a vitamin mixture containing 600 mg oL-tocopherol for 6 weeks significantly decreased levels of serum MDA and expired pentane, both at rest and after 30 min of treadmill exercise at 60 and 90% VO2max. Goldfarb et al (62) report that rats supplemented with a 250 IU vitamin E/kg diet for 5 weeks have lower TBARS and lipid peroxide levels in plasma and leg muscles after one hour treadmill exercise compared to controls.…”

Section: Non-enzymatic Antioxidantsmentioning

confidence: 99%

“…Alessio and Goldfarb (27) show that lipid peroxidation measured by thiobarbituric acid reactive substance (TBARS) was correlated with treadmill workload in rats. Also, Kanter et al (28) report an increased pentane in expired air of human subjects as evidence of tissue lipid peroxidation, and that the pentane concentration is increased proportionally with workload. Furthermore, Ji et al (29) show that the oxidation of GSH to glutathione disulfide (GSSG) in skeletal muscle increased as a function of workload in rats running on a treadmill.…”

Section: Mitochondrial Theorymentioning

confidence: 99%

Exercise and oxidative stress: Sources of free radicals and their impact on antioxidant systems

Leichtweis

1997

AGE

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Strenuous exercise is characterized by increased oxygen consumption and the disturbance between intracellular pro-oxidant and antioxidant homeostasis. At lease three biochemical pathways (i.e., mitochondrial electron transport chain, xanthine oxidase, and polymorphoneutrophil) have been identified as potential sources of intracellular free radical generation during exercise. These deleterious reactive oxygen species pose a serious threat to the cellular antioxidant defense system, such as diminished reserves of antioxidant vitamins and glutathione. However, enzymatic and non-enzymatic antioxidants have demonstrated great versitility and adaptability in response to acute and chronic exercise. The delicate balance between pro-oxidants and antioxidants suggests that supplementation with antioxidants may be desirable for physically active individuals under certain physiological conditions by providing a larger protective margin.

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Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise

Cited by 264 publications

References 0 publications

Plasma antioxidant status and cell injury after severe physical exercise

Plasma antioxidant status and cell injury after severe physical exercise

El acoplamiento excitación-contracción en el músculo esquelético: preguntas por responder a pesar de 50 años de estudio

Exercise and oxidative stress: Sources of free radicals and their impact on antioxidant systems

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