Effects of aluminum on rat cerebellar cortex and the possible protective role of Nigella sativa

Ibrahim, Kamal; Kamal, Heba

doi:10.1097/01.ehx.0000440828.86537.e7

Cited by 8 publications

(5 citation statements)

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“…Many workers who deal with aluminum are prone to respiratory diseases and breathing impairments, which can result in chronic obstructive pulmonary disease [ 12 , 13 ]. Aluminum can impact human organs, tissues and cells, such as the alveolar of pulmonary tissues, renal tissues, hepatocytes, blood, the hippocampus and the cerebrum [ 14 , 15 , 16 ]. Moreover, chronic or long-term exposure to aluminum silicate leads to the sedimentation of the metal in the lung as well as in other tissues and organs, causing many metabolic disorders, histological damages, membrane changes and alterations to diseases [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies

et al. 2020

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In this study, we evaluated the inflammatory responses induced by aluminum silicate (AS) cytotoxicity in rat lungs. The prophylactic effect of propolis extract was evaluated in 60 adult male albino rats. The rats were divided into six groups: (1) a normal, healthy control group; (2) a normal group fed with 200 mL of propolis extract/Kg; (3) a low-dose positive control group injected with 5 mg/kg of AS; (4) a treated group given propolis and a low dose of AS; (5) a high-dose positive control group injected with 20 mg/kg of AS; and (6) a treated group given propolis with a high-dose of AS. At the end of the two-month experiment, the rats’ lungs were removed. For each pair of lungs, one portion was subjected to biochemical analysis and the other underwent hematoxylin and eosin (H&E) staining in order to study its histology. The rats that received AS doses displayed significant disorders in their antioxidant contents as well as in their enzymatic activities and their histopathological structures revealed severe damage to their lung tissues. Upon the rats being treated with propolis, the enzymatic and antioxidant contents improved and partial improvements in the lung structures appeared, including minimized congestion, a reduced hemorrhage of blood vessels and preserved bronchioles, alveolar ducts, and alveoli. The prophylactic effectiveness of propolis extract on the cytotoxicity of AS, owing to the antioxidant properties of propolis, were studied.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies

et al. 2020

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“…Ultrastructurly, the granular neurons had heterochromatic nuclei with irregular nuclear envelopes and some of them had vacuolated cytoplasm in group III. This finding was explained by exposure of cerebellar granular cells to oxidative stress [49,50] . Previous investigators [15] suggested that granular cells changes were secondary to alterations occurred in Purkinje neurons leading to gradual loss of synchronization between both nerve cells.…”

Section: Discussionmentioning

confidence: 99%

Histological and immunohistochemical study on the effect of zinc oxide nanoparticles on cerebellar cortex of adult male albino rats

Abdel-aziz

Mekawy

Ibrahem

2019

Egyptian Journal of Histology

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Background: Zinc oxide nanoparticles (ZnONPs) are one of metal nanoparticles that have widespread use in many fields. Objective: To investigate the effect of ZnONPs on cerebellar cortex of rats through histological and immunohistochemical study. Materials and methods: Thirty adult male albino rats were divided into three groups; group I (control), Group II (ZnONP-1 treated group) which received orally 50 mg/kg of ZnONP for two months and Group III (ZnONP-1I treated group) which received orally 200 mg/kg of ZnONP for two months. Specimens of the cerebellar cortex were processed for histological and immunohistochemical study. Morphometric and statistical analysis were carried out. Results: Group II showed Purkinje cells were crowded in many layers surrounded by perineuronal vacuoles and had pyknotic nuclei. They had cytoplasmic vacuoles and perinuclear Golgi apparatus revealed fragmented dilated cisternae. Nearby Bergmann astrocyte cells had highly vacuolated cytoplasm and the nerve fibers were also affected and showed dysmyleination (disrupted myelin sheath). Immunohistochemical study of the same group showed Purkinje cell cytoplasm had positive immunoreactions for calretinin proteins. In group III, there was a wide spread of neuronal affection to the degree of loss of many of Purkinje cells leaving empty spaces. Ultrastructurly, their cytoplasm appeared with multiple variable sized and had dilated mitochondria with disrupted cristae. The Bergmann astrocytes revealed nuclei with disrupted nuclear envelope and nearly absence their cytoplasmic organelle and there was more affection to the nerve fibers in the form of vacuolated axoplasm and demyelination (areas of myelin loss) beside dysmyleination. Immunohistochemical study of group III showed Purkinje cells cytoplasm with negative immunoreactions for calretinin proteins. Conclusion: Intake of ZnONPs induced various adverse alterations in the histological and immunohistochemical structures of cerebellar cortex indicating the occurrence of neurotoxicity. These changes were exaggerated with increasing the dose of their intake.

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“…Kamal and Kamal reported that administration of Al in the rat cerebellum significantly reduced the number of Purkinje cells and induced some damages such as cytoplasmic vacuolation, dilatation of Golgi cisternae, and mitochondria with dilated cristae in Purkinje cells and administration of N. sativa with Al showed a noticeable protection against these alterations. 13…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa and its Derivatives as Food Toxicity Protectant Agents

et al. 2019

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Exposure to food toxins generate multiple adverse health effects. Heavy metals, antibioticsresidue, mycotoxins, pesticides and some food additives are examples of the most importantfood toxins. The common mechanism of toxicity and carcinogenicity effects of food toxins is thegeneration of oxidative stress that leads to DNA damages. Moreover, based on epidemiologicevidence unhealthy eating habits and food toxicities are associated with cancers occurrence.Therefore, application of bioactive food additives as harmless or safe components in foodindustry is expensive. Nigella sativa L. is a broadly used herb-drug for various diseases all overthe world and has been used as preservative and food additive. Based on various studies N. sativahas shown various pharmacological activities including therapeutic efficacy against differenthuman diseases and antioxidant anti-inflammatory effects against environmental toxins. N.sativa decreases the adverse health effects induced by mentioned food toxins via modulating theaction of antioxidant enzymes such as glutathione peroxidase (GPx), glutathione-S-transferasecatalase and act as reactive oxygen species (ROS) scavengers in different organs. Besides, N.sativa and thymoquinone (TQ) have protective effects on food products through removal andinhibition of various toxic compounds. Therefore, in the present review we will describe allprotective effects of N. sativa and its main constituents, TQ, against food induced toxicities.

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Effects of aluminum on rat cerebellar cortex and the possible protective role of Nigella sativa

Cited by 8 publications

References 1 publication

Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies

Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies

Histological and immunohistochemical study on the effect of zinc oxide nanoparticles on cerebellar cortex of adult male albino rats

Nigella sativa and its Derivatives as Food Toxicity Protectant Agents

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