Effects of Altered Levels of Pro- and Anti-Inflammatory Mediators on Locations of In-Stent Reocclusions in Elderly Patients

Abstract

Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators were involved in the pathogenesis of atherosclerosis. This study sought to investigate the effects of proatherogenic inflammatory and antiatherogenic inflammatory mediators on the proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations. We measured the expression levels of proatherogenic inflammatory/antiatherogenic inflammatory cytokines. This included interleukin-1 β (IL-1 β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10), interleukin-17 (IL-17), interleukin-13 (IL-13), and interleukin-37 (IL-37) in the elderly patients with the proximal, middle, and distal coronary artery reocclusions after coronary stent implantations. Levels of IL-1 β, IL-6, IL-8, TNF-α, and hs-CRP were remarkably increased (P<0.001), and levels of IL-10, IL-17, IL-13, and IL-37 were remarkably lowered (P<0.001) in the elderly patients with the proximal, middle, and distal coronary artery reocclusions. Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators may be involved in the formation and progression of proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations.

Neutrophil and lymphocyte count as predictors of the location of calcific coronary lesions in patients treated with rotational atherectomy

“…Moreover, the proximal and distal atherosclerotic lesions presented different histological compositions [9] due to diverse pathophysiological processes involved in the development and progression of the plaques. In Li et al's study [20] the differences between proatherogenic inflammatory and antiatherogenic inflammatory markers, including interleukins (IL) (IL-1β, IL-6, IL-8, IL-10, IL-17, IL-13, IL-37), TNF-α, and hs-CRP were related to different occlusion risk after percutaneous coronary procedures in the proximal, medial, or distal segments of the vessels.…”

Perfil Dos Medicamentos Utilizados Pela População De Um Município Da Região Sul Do Brasil: Estratégias Para a Assistência E Assistência Farmacêutica

“…Eles pertencem a uma classe de medicamentos mais difundidas em todo mundo, sendo bastante utilizados em casos de dor aguda ou crônica devido a processos inflamatórios. Os AINEs são comumente utilizados por apresentarem propriedade analgésica, antitérmica, anti-inflamatória e antitrombótica, atuam através da inibição de prostaglandinas (PGs) (Quadro 1), que são substâncias endógenas intermediárias do processo inflamatório, pela inativação das isoenzimas cicloxigenases constitutiva (COX1) e indutiva (COX-2) (MOREIRA et al, 2017;LI et al, 2020). Embora garantir o acesso gratuito a medicamentos à população carente seja parte importante da assistência à saúde, integrar a assistência farmacêutica e médica à atenção básica é uma estratégia fundamental para garantir o uso racional de medicamentos e a redução do desperdício farmacêutico.…”