Effects of alkaloid-rich extracts obtained from Grifola frondosa on gut microbiota and glucose homeostasis in rats

Abstract

Grifola frondosa (GF), also known as maitake (a type of mushroom), has been widely used as a food item and it exhibits various health-beneficial hypoglycemic activities. Rats fed with a...

Grifolamine A, a novel bis-γ-butyrolactone from Grifola frondosa exerted inhibitory effect on α-glucosidase and their binding interaction: Affinity and molecular dynamics simulation

“…The edible mushroom Grifola frondosa , also known as maitake, has been used as a food delicacy and a traditional dietary nutritional supplement for a long history in Asian countries. Over the last few decades, accumulated evidences demonstrated that G. frondosa had outstanding pharmacological properties including hypoglycemic, hypolipidemic, anti-tumor, and immunomodulatory ( Li et al, 2022 ; Mizuno et al, 2017 ; Ouyang et al, 2022 ; Zhang et al, 2022 ). These bioactivities might be attributed to its multiple metabolites including polysaccharides, sterols, ceramides and alkaloids ( Chen et al, 2018 ; Meng et al, 2017 ; Yaoita et al, 2000 ; A.…”